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Sterility Produced in Mice by Deuterium Oxide

Description: Sterility in C{sub 57} and Swiss mice has been produced by substituting D{sub 2}O for a part of the drinking water. The effective range lies between 5% and 30% D{sub 2}O. It appears that the effect is greater in C{sub 57} males than females and that the size and viability of the litter is affected.
Date: December 6, 1957
Creator: Hughes, Ann M. & Calvin, Melvin
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Endangered species and cultural resources program Naval petroleum Reserves in California. Annual report FY96

Description: In FY96, Enterprise Advisory Services, Inc. (EASI) continued to support efforts to protect endangered species and cultural resources at the Naval Petroleum Reserves in California (NPRC). These efforts are conducted to ensure NPRC compliance with regulations regarding the protection of listed species and cultural resources on federal properties. Population monitoring activities were conducted for San Joaquin kit foxes, giant kangaroo rats, blunt-nosed leopard lizards, and Hoover`s wooly-star. Ki… more
Date: July 1, 1997
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice

Description: Aneuploidy, the most common chromosomal abnormality at birth and the main ascertained cause of pregnancy loss in humans, originates primarily from chromosome segregation errors during oogenesis. Here we report that heterozygosity for a mutation in the mitotic checkpoint kinase gene, Bub1, induces aneuploidy in female germ cells of mice, and that the effect increases with advancing maternal age. Analysis of Bub1 heterozygous oocytes showed that aneuploidy occurred primarily during the first meio… more
Date: June 24, 2009
Creator: Leland, Shawn; Nagarajan, Prabakaran; Polyzos, Aris; Thomas, Sharon; Samaan, George; Donnell, Robert et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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BIO-ORGANIC CHEMISTRY QUARTERLY REPORT. March through05/1963

Description: This report covers the following titles: (1) Fertility and litter size of normally ovulated and artificially ovulated mice; (2) Further studies on sterility produced in male mice by deuterium oxide; (3) Planarian disaggregation; (4) Uptake of organic compounds by planarians. II; (5) Effects of environmental complexity and training on acetylcholinesterase and cholinesterase activity in rat brain; (6) Effects of environmental complexity and training on brain chemistry and anatomy among mature rat… more
Date: July 23, 1963
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Inhalation developmental toxicology studies of 1,3-butadiene in the rat: Final report

Description: Maternal toxicity, reproductive performance and developmental toxicology were evaluated in Sprague-Dawley-derived rats during and following 6 hours/day, whole-body, inhalation exposures to 0, 40, 200, and 1000 ppM of 1,3-butadiene. The female rats (Ns = 24 to 28), which had mated with unexposed males, were exposed to the chemical from 6 through 15 dg and sacrificed on 20 dg. Maternal animals were weighed prior to mating and on 0, 6, 11, 16 and 20 dg; the rats were observed for mortality, morbid… more
Date: November 1, 1987
Creator: Hackett, P. L.; Sikov, M. R.; Mast, T. J.; Brown, M. G.; Buschbom, R. L.; Clark, M. L. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Inhalation developmental toxicology studies: Teratology study of 1,3-butadiene in mice: Final report

Description: Maternal toxicity, reproductive performance and developmental toxicology were evaluated in CD-1 mice following whole-body, inhalation exposures to 0, 40, 200 and 1000 ppM of 1,3-butadiene. The female mice, which had mated with unexposed males were exposed to the chemical for 6 hours/day on 6 through 15 dg and sacrificed on 18 dg. Maternal animals were weighed prior to mating and on 0, 6, 11 and 18 dg; the mice were observed for mortality, morbidity and signs of toxicity during exposure and exam… more
Date: November 1, 1987
Creator: Hackett, P. L.; Sikov, M. R.; Mast, T. J.; Brown, M. G.; Buschbom, R. L.; Clark, M. L. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Sperm-head morphology study in B6C3F1 mice following inhalation exposure to 1,3-butadiene: Final technical report

Description: The present report describes the results of a study of the morphology of epididymal sperm heads of B6C3F1 mice that were exposed to varying concentrations of 1,3-butadiene. During the fifth post-exposure week, the animals were killed and examined for gross lesions of the reproductive tract; suspensions of the epididymal sperm were prepared for morphologic evaluations. No mortality was observed in any of the inhalation exposure groups. Transient toxic signs, including piloerection and dyspnea, w… more
Date: April 1, 1988
Creator: Hackett, P. L.; McClanahan, B. J.; Brown, M. G.; Buschbom, R. L.; Clark, M. L.; Decker, J. R. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Inhalation developmental toxicology studies: Teratology study of isoprene in mice and rats: Final report

Description: Isoprene, a reactive, branched diene, is used in large quantities in the manufacture of polyisoprene and as a copolymer in the synthesis of butyl rubber. The potential for isoprene to cause developmental toxicity was assessed in rodents, by exposing four groups each of Sprague-Dawley rats and Swiss (CD-1) mice to 0, 280, 1400, or 7000 ppM isoprene vapors, 6 h/day, 7 day/wk. Each treatment group consisted of 10 virgin females (for comparison), and approx.30 positively mated rats or mice. Positiv… more
Date: January 1, 1989
Creator: Mast, T. J.; Evanoff, J. J.; Stoney, K. H.; Westerberg, R. B.; Rommereim, R. L. & Weigel, R. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Inhalation developmental toxicology studies: Teratology study of methyl ethyl ketone in mice: Final report

Description: Methyl ethyl ketone (MEK) is a widely used industrial solvent which results in considerable human exposure. In order to assess the potential for MEK to cause developmental toxicity in rodents, four groups of Swiss (CD-1) mice were exposed to 0, 400, 1000 or 3000 ppM MEK vapors, 7 h/day, 7 dy/wk. Ten virgin females and approx.30 plug-positive females per group were exposed concurrently for 10 consecutive days (6--15 dg for mated mice). Body weights were obtained throughout the study period, and … more
Date: February 1, 1989
Creator: Mast, T. J.; Dill, J. A.; Evanoff, J. J.; Rommereim, R. L.; Weigel, R. J. & Westerberg, R. B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Inhalation developmental toxicology studies: Teratology study of acetone in mice and rats: Final report

Description: Acetone, an aliphatic ketone, is a ubiquitous industrial solvent and chemical intermediate; consequently, the opportunity for human exposure is high. The potential for acetone to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 440, 2200, or 11000 ppm, and in Swiss (CD-1) mice exposed to 0, 440, 2200, and 6600 ppm acetone vapors, 6 h/day, 7 days/week. Each of the four treatment groups consisted of 10 virgin females (for comparison), and approx.32 positively mated r… more
Date: November 1, 1988
Creator: Mast, T. J.; Evanoff, J. J.; Rommereim, R. L.; Stoney, K. H.; Weigel, R. J. & Westerberg, R. B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Radiation induced micrencephaly in guinea pigs

Description: A brain weight deficit of about 70 mg was induced at doses of approximately 75-mGy and a deficit of 60 mg was induced at 100 mGy. This confirms the effects projected and observed by Wanner and Edwards. Although the data do not demonstrate a clear dose-response relationship between the 75-mGy and 100-mGy groups, the data are statistically consistent with a dose-response effect because of the overlapping confidence intervals. The lack of a statistically significant observation is most likely rela… more
Date: January 1, 1991
Creator: Wagner, L.K.; Johnston, D.A. & Felleman, D.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Inhalation developmental toxicology studies: Teratology study of tetrahydrofuran in mice and rats: Final report

Description: Tetrahydrofuran (THF), a four-carbon cyclic ether, is widely used as an industrial solvent. Although it has been used in large quantities for many years, few long-term toxicology studies, and no reproductive or developmental studies, have been conducted on THF. This study addresses the potential for THF to cause developmental toxicity in rodents by exposing Sprague-Dawley rats and Swiss (CD-1) mice to 0, 600, 1800, or 5000 ppm tetrahydrofuran (THF) vapors, 6 h/day, 7 dy/wk. Each treatment group… more
Date: August 1, 1988
Creator: Mast, T. J.; Evanoff, J. J.; Stoney, K. H.; Westerberg, R. B.; Rommereim, R. L. & Weigel, R. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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