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A Study of the Role of Complement in the Protection of Akr Mice Against Transplanted Lymphoid Leukemia

Description: It seemed desirable to investigate further the possible role of complement and its components in the protective action of serum against transplanted neoplasms. It is the purpose of this thesis to present data which suggest that the C'4 component plays an active part in this process though the mechanism is not disclosed.
Date: 1957
Creator: Schlagenhauf, George Kenneth
Partner: UNT Libraries

Histochemical Characterization of Lymphocytes in Preleukemic and Leukemic AKR Mice

Description: The AKR strain of mice have a genetic trait for spontaneous development of lymphocytic leukemia. In this study, leukemic mice were found to have significantly larger (p<0.01) thymuses and spleens than preleukemic mice. The enlarged leukemic tissues were densely packed with a light staining cell, with a hollow-appearing nucleus. Tissues from preleukemic mice were observed to be infiltrated with a smaller, darker-staining lymphocyte. Fluorescent antibody staining was done on preleukemic and leukemic tissues, using three antisera against murine lymphocyte theta antigen, and an antiserum against murine IgG. Significantly brighter fluorescence, (p <0.05) with theta-specific antisera, was found in leukemic thymuses,spleens, and kidneys than in the same preleukemic tissues. Leukemic tissues had significantly brighter fluorescence (p <0.05) than preleukemic tissues with IgG antiserum.
Date: May 1979
Creator: Michnoff, Carolyn A.
Partner: UNT Libraries

Membrane antigens on AKR mice lymphocytes

Description: This investigation is concerned with cell surface antigens present on murine AKR/J mice spleen and thymus cells which have been extracted with papain. Isolation of individual proteins was accomplished by granulated gel electrofocusing. Similar patterns recorded by both electrofocusing procedures identified several proteins limited to the AKR/J and C3Heb/FeJ spleen and thymus samples, which represent Murine Leukemia Virus-associated surface proteins.
Date: December 1978
Creator: Eisinger, Robert W.
Partner: UNT Libraries


Description: This article deals with Jose Vazquez and the struggle that he and his family face because of leukemia. Both the original Spanish article and the English translation are included.
Date: April 25, 2006
Creator: Castillo, José L.
Partner: UNT Libraries Special Collections

Personality Characteristics of Pediatric Leukemia Patients: Their Mothers' Perceptions

Description: The improving prognosis for pediatric leukemia patients requires that involved professionals increase attention to the emotional adjustment of these children. This study was designed to determine (a) how mothers of leukemia patients perceived their children's personalities in order to identify any specific emotional difficulties which these children may experience and (b) if their perceptions differed from either mothers of cystic fibrosis and diabetes patients or mothers of healthy children. Subjects included 24 mothers in each of three groups: leukemia, other illness, and healthy. Children in both illness groups received higher scores than healthy children on Adjustment, Achievement, Somatic Concern, Depression, Psychosis, and Social Skills scales as measured by the Personality Inventory for Children; however, only the leukemic children were rated higher in areas of Anxiety and Withdrawal. Implications for treatment and future research are discussed.
Date: August 1985
Creator: Hughes, Sandra A.
Partner: UNT Libraries

Detection of BCR-ABL Fusion mRNA Using Reverse Transcriptase Loop-mediated Isothermal Amplification

Description: RT-PCR is commonly used for the detection of Bcr-Abl fusion transcripts in patients diagnosed with chronic myelogenous leukemia, CML. Two fusion transcripts predominate in CML, Br-Abl e13a2 and e14a2. They have developed reverse transcriptase isothermal loop-mediated amplification (RT-LAMP) assays to detect these two fusion transcripts along with the normal Bcr transcript.
Date: December 8, 2011
Creator: Dugan, L. C.; Hall, S.; Kohlgruber, A.; Urbin, S.; Torres, C. & Wilson, P.
Partner: UNT Libraries Government Documents Department

Application of multidisciplinary analysis to gene expression.

Description: Molecular analysis of cancer, at the genomic level, could lead to individualized patient diagnostics and treatments. The developments to follow will signal a significant paradigm shift in the clinical management of human cancer. Despite our initial hopes, however, it seems that simple analysis of microarray data cannot elucidate clinically significant gene functions and mechanisms. Extracting biological information from microarray data requires a complicated path involving multidisciplinary teams of biomedical researchers, computer scientists, mathematicians, statisticians, and computational linguists. The integration of the diverse outputs of each team is the limiting factor in the progress to discover candidate genes and pathways associated with the molecular biology of cancer. Specifically, one must deal with sets of significant genes identified by each method and extract whatever useful information may be found by comparing these different gene lists. Here we present our experience with such comparisons, and share methods developed in the analysis of an infant leukemia cohort studied on Affymetrix HG-U95A arrays. In particular, spatial gene clustering, hyper-dimensional projections, and computational linguistics were used to compare different gene lists. In spatial gene clustering, different gene lists are grouped together and visualized on a three-dimensional expression map, where genes with similar expressions are co-located. In another approach, projections from gene expression space onto a sphere clarify how groups of genes can jointly have more predictive power than groups of individually selected genes. Finally, online literature is automatically rearranged to present information about genes common to multiple groups, or to contrast the differences between the lists. The combination of these methods has improved our understanding of infant leukemia. While the complicated reality of the biology dashed our initial, optimistic hopes for simple answers from microarrays, we have made progress by combining very different analytic approaches.
Date: January 1, 2004
Creator: Wang, Xuefel (University of New Mexico, Albuquerque, NM); Kang, Huining (University of New Mexico, Albuquerque, NM); Fields, Chris (New Mexico State University, Las Cruces, NM); Cowie, Jim R. (New Mexico State University, Las Cruces, NM); Davidson, George S.; Haaland, David Michael et al.
Partner: UNT Libraries Government Documents Department

The sequence and analysis of duplication rich human chromosome 16

Description: Human chromosome 16 features one of the highest levels of segmentally duplicated sequence among the human autosomes. We report here the 78,884,754 base pairs of finished chromosome 16 sequence, representing over 99.9% of its euchromatin. Manual annotation revealed 880 protein-coding genes confirmed by 1,637 aligned transcripts, 19 tRNA genes, 341 pseudogenes, and 3 RNA pseudogenes. These genes include metallothionein, cadherin, and iroquois gene families, as well as the disease genes for polycystic kidney disease and acute myelomonocytic leukemia. Several large-scale structural polymorphisms spanning hundreds of kilobase pairs were identified and result in gene content differences among humans. While the segmental duplications of chromosome 16 are enriched in the relatively gene poor pericentromere of the p-arm, some are involved in recent gene duplication and conversion events likely to have had an impact on the evolution of primates and human disease susceptibility.
Date: April 6, 2005
Creator: Martin, J; Han, C; Gordon, L A; Terry, A; Prabhakar, S; She, X et al.
Partner: UNT Libraries Government Documents Department