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RadSTraM: Radiological Source Tracking and Monitoring, Phase II Final Report

Description: This report focuses on the technical information gained from the Radiological Source Tracking and Monitoring (RadSTraM) Phase II investigation and its implications. The intent of the RadSTraM project was to determine the feasibility of tracking radioactive materials in commerce, particularly International Atomic Energy Agency (IAEA) Category 3 and 4 materials. Specifically, Phase II of the project addressed tracking radiological medical isotopes in commerce. These categories of materials are susceptible to loss or theft but the problem is not being addressed by other agencies.
Date: December 1, 2008
Creator: Warren, Tracy A; Walker, Randy M; Hill, David E; Gross, Ian G; Smith, Cyrus M & Abercrombie, Robert K
Partner: UNT Libraries Government Documents Department

Frontiers in nuclear medicine symposium: Nuclear medicine & molecular biology

Description: This document contains the abstracts from the American College of Nuclear Physicians 1993 Fall Meeting entitled, `Frontiers in Nuclear Medicine Symposium: Nuclear Medicine and Molecular Biology`. This meeting was sponsored by the US DOE, Office of Health and Environmental Research, Office of Energy Research. The program chairman was Richard C. Reba, M.D.
Date: April 1, 1995
Partner: UNT Libraries Government Documents Department

Analysis of individual lipoproteins and liposomes

Description: We describe the application of single molecule detection (SMD) technologies for the analysis of natural (serum lipoproteins) and synthetic (liposomes) transport systems. The need for advanced analytical procedures of these complex and important systems is presented with the specific enhancements afforded by SMD with flowing sample streams. In contrast to bulk measurements which yield only average values, measurement of individual species allows creation of population histograms from heterogeneous samples. The data are acquired in minutes and the analysis requires relatively small sample quantities. Preliminary data are presented from the analysis of low density lipoprotein, and multilamellar and unilamellar vesicles.
Date: August 1, 1997
Creator: Robbins, D.L.; Keller, R.A. & Nolan, J.P.
Partner: UNT Libraries Government Documents Department

Resolution of the spectral technique in kinetic modeling

Description: Physiologic systems can be represented by compartmental models which describe the uptake of radio-labeled tracers from blood to tissue and their subsequent washout. Arterial and venous time-activity curves from isolated heart experiments are analyzed using spectral analysis, in which the impulse response function is represented by a sum of decaying exponentials. Resolution and uniqueness tests are conducted by synthesizing isolated heart data with predefined compartmental models, adding noise, and applying the spectral analysis technique. Venous time-activity curves are generated by convolving a typical arterial input function with the predefined spectrum. The coefficients of a set of decaying exponential basis functions are determined using a non-negative least squares algorithm, and results are compared with the predefined spectrum. The uniqueness of spectral method solutions is investigated by computing model covariance matrices, using error propagation and prior knowledge of noise distributions. Coupling between model parameters is illustrated with correlation matrices.
Date: February 17, 2001
Creator: Kuo, Chaincy; Reutter, Bryan W. & Huesman, Ronald H.
Partner: UNT Libraries Government Documents Department

The first synthesis of [9,Amino-{sup 15}N{sub 2}]adenine and {beta}- 2{prime}-Deoxy-[9,Amino-{sup 15}N{sub 2}]adenosine

Description: {beta}-2{prime}-Deoxy-[9, Amino-{sup 15}N{sub 2}] Adenosine has been constructed in 4 steps from commercially available 5-amino-4,6-dichloropyrimidine and {sup 15}NH{sub 3}. The reactions have been scaled provide grams quantities of labeled nucleoside.
Date: December 31, 1995
Creator: Orji, C.C. & Silks, L.A. III
Partner: UNT Libraries Government Documents Department

Internal dosimetry of tritium

Description: Tritium is an interesting radionuclide from the perspective of internal dosimetry because of the wide variety of chemical compounds in which it can appear, its unusual routes of entry into the body, and its ability to exchange with stable hydrogen in surrounding material. In this report the internal dosimetry of tritium compounds is reviewed, with emphasis on methods of evaluating bioassay data following chronic and acute intakes. The assumptions and models used in the derivation of Annual Limits on Intake (ALI) and Derived Air Concentrations (DAC) for tritium are also discussed.
Date: June 1, 1992
Creator: LaBone, T. R.
Partner: UNT Libraries Government Documents Department


Description: The amino acid composition of collagen and the role of collagen in bone formation are reviewed. It is pointed out that glycine is the predominant amino acid of collagen. Results are reported from a serial, autoradiographic study of the localization and distribution of H/sup 3/ in the femora of young mice following the administration of H/sup 3/-glycine. The functional behavior and capacity of different skeletal cells in matrix production are discussed. (26 references.) (C.H.)
Date: January 1, 1962
Creator: Tonna, E.A.; Cronkite, E.P. & Pavelec, M.
Partner: UNT Libraries Government Documents Department


Description: Sequential autoradiographed sections through the shoot apical meristem of Arabidopsis thaliana treated for six hours with a solution of H/sup 3/- thymidine in combination with 0.1% Tween 20 and dilute mineral solution reveal a differential pattern of labeling, indicative of differential rates of DNA synthesis. This pattern corresponds to the histological zonation of the apex and reveals a sub-apical block of cells in which the amount of incorporation is significantly lower than in the adjacent flank cells. (auth)
Date: January 1, 1962
Creator: Brown, J.A.M.; Miksche, J.P. & Smith, H.H.
Partner: UNT Libraries Government Documents Department


Description: Vitamin B/sub 12/, labeled with Co/sup 60/ having a specific activity of 1.0 mu C/ mu g, was administered to 18 patients in the late stages of malignandt diseases. Death occurred 11 hr to 695 days after Co -- B/sub 12/ administration. Data are presented on the distribution of Co -- B/sub 12/ in tissues andd organds obtained at post-mortem examination. From 16.8 to 108% was in the liver, with lesser amounts in the othef organds and tissues. Variations resulted from the route of administration, disesse state, and interval between administration and death. (C.H.)
Date: January 1, 1962
Creator: Meyer, L.M.; Driscoll, D.H.; Cronkite, E.P. & Bertcher, R.W.
Partner: UNT Libraries Government Documents Department

Chemical Effects of Nuclear Transformations and Their Use in Making Labeled Compounds

Description: The chemical effects of nuclear transformations can be utilized to introduce the radioactive atoms produced into chemical species useful for tracer studies. Gas chromatography offers a means of separating the tagged compounds with high specific activity. A chromatographic apparatus for separating and identifying labeled compounds is described. Comparisons are made of this with other labeling techniques. (auth)
Date: January 1, 1957
Creator: Evans, J.B.; Quinlan, J.E. & Willard, J.E.
Partner: UNT Libraries Government Documents Department

Current titles

Description: This booklet is published for those interested in current research being conducted at the National Center for Electron Microscopy. The NCEM is a DOE-designated national user facility and is available at no charge to qualified researchers. Access is controlled by an external steering committee. Interested researchers may contact Gretchen Hermes at (510) 486-5006 or address below for a User`s Guide. Copies of available papers can be ordered from: Theda Crawford National Center for Electron Microscopy, Lawrence Berkeley Laboratory, One Cyclotron Rd., MS72, Berkeley, California, USA 94720.
Date: July 1, 1995
Partner: UNT Libraries Government Documents Department

Development of an expression system for eukarytoic proteins in methylotropic bacteria

Description: The objective of this project was to develop an expression vector for methylotrophic bacteria for use in the production of C{sup 13} and H{sup 2} labelled eukaryotic proteins by growing methylotrophic bacteria on labelled methanol or methylamine. The eukaryotic proteins calmodulin and troponin C were chosen as test cases. Genes encoding both proteins were cloned into different constructions and tested for expression. Moderate amounts of troponin C were found with one of the constructions.
Date: September 1, 1996
Creator: Lidstrom, M.E.
Partner: UNT Libraries Government Documents Department

Production and application of synthetic precursors labeled with carbon-11 and fluorine-18

Description: It is evident from this chapter that there is enormous flexibility both in the selection of the nature of the radioisotope and ways to generate it, as well as in the selection of the labeling precursor to appropriately attach that radioisotope to some larger biomolecule of interest. The arsenal of radiolabeling precursors now available to the chemist is quite extensive, and without a doubt will continue to grow as chemists develop new ones. However, the upcoming years will perhaps reflect a greater effort in refining existing methods for preparing some of those precursors that are already available to us. For example, the use of solid-phase reactions to accomplish in a single step what would normally take several using conventional solvent-based reactions has already been shown to work in many occasions. The obvious advantage here is that processes become more amenable to system automation thus affording greater reliability in day-to-day operations. There are perhaps other technologies in science that have yet to be realized by the chemist in the PET laboratory that could provide a similar or even a greater benefit. One only needs to be open to new ideas, and imaginative enough to apply them to the problems at hand.
Date: April 2, 2001
Creator: Ferrieri, R. A.
Partner: UNT Libraries Government Documents Department

Medical Applications of Gadolinium and/or Boron-Labeled Pharmaceuticals

Description: Boron neutron capture therapy (BNCT) is a binary treatment modality that can selectively irradiate tumor tissue. The key to effective BNCT is the preferential accumulation of <sup>10</sup>B in the tumor relative to the surrounding normal tissues. A screening procedure was developed under this CRADA that is an improvement over previously reported techniques. This method was used to evaluate the two compounds produced by BBI, the amino acid p-boronophenylalanine (BPA)and the sulfhydryl boroane N<sub>2</sub>B<sub>12</sub>H<sub>11</sub>SH (BSH), for clinically useful accumulation in a panel of human tumor cell lines. BPA showed selective accumulation in: squamous cell carcinoma of the lung; small cell carcinoma of the lung; osteosarcoma; prostate carcinoma; and ovarian carcinoma. Of these it was decided to pursue application of BPA-based BNCT to lung tumors. BPA distribution in nude mice bearing subcutaneous human lung tumor xenografts showed very favorable results. At 3 hours post-injection, the tumor/blood boron concentration ratio was 5:1, the tumorflung ratio was 6:1. The treatment planning sofiware, already in use for the glioblastoma BNCT clinical trial underway at BNL, was used for simulation of a human lung tumor treatment using BNCT. Input data for this simulation included the nude mouse biodistribution data, human lung tumor CT geometry, and the same assumptions about relative biological effectiveness of the BNCT dose components currently in use for the human brain tumor trial. The results of this lung tumor simulation indicate significant sparing of normal lung compared to tumor. We conclude that the BBI product BPA has potential applications in BNCT of other tumor sites. BPA-based BNCT for human small cell carcinoma of the lung looks promising. Further studies into the radiation biology of the normal lung will be required prior to clinical BNCT for lung tumors.
Date: October 1, 1997
Creator: Coderre, J A & Spielvogel, B
Partner: UNT Libraries Government Documents Department

Raman characterization of the BEDT-TTF(ClO{sub 4}){sub 2} salt

Description: The major Raman scattering peaks of BEDT-TTF(ClO{sub 4}){sub 2} have been assigned by comparison to the isotopically labeled {sup 13}C(4)-BEDT-TTF(ClO{sub 4}){sub 2} and {sup 13}C(6)-BEDT-TTF(ClO{sub 4}){sub 2} salts. The {upsilon}{sub 2}, {upsilon}{sub 3}, and {upsilon}{sub 6} A{sub g} modes are associated with the C{double_bond}C vibrations and the Raman shifts are found to decrease with increasing oxidation state of the ET molecules. The {upsilon}{sub 9} and {upsilon}{sub 10} A{sub g} modes are associated with the sulfur (C{single_bond}S) related vibrations and the Raman shifts are observed to increase with increasing oxidation state of the ET molecules.
Date: December 31, 1995
Creator: Wang, H.H.; Kini, A.M. & Williams, J.M.
Partner: UNT Libraries Government Documents Department

Development of gamma emitting receptor binding radiotracers for imaging the brain and pancreas. Final technical progress report, March 1, 1988--May 31, 1993

Description: This document give paragraph synopses of results in research on brain and pancreas imaging, using radiotracers. General catagories of research included chemistry, pharmacology, imaging physics, and kinetic modeling. A list of publications is included
Date: January 1, 1996
Partner: UNT Libraries Government Documents Department

The antibody approach of labeling blood cells

Description: Although the science of blood cell labeling using monoclonal antibodies directed against specific cellular antigens is still in its early stages, considerable progress has recently been accomplished in this area. The monoclonal antibody approach offers the promise of greater selectivity and enhanced convenience since specific cell types can be labeled in vivo, thus eliminating the need for complex and damaging cell separation procedures. This article focuses on these developments with primary emphasis on antibody labeling of platelets and leukocytes. The advantages and the shortcomings of the recently reported techniques are criticality assessed and evaluated.
Date: December 31, 1991
Creator: Srivastava, S. C.
Partner: UNT Libraries Government Documents Department

Target design considerations for high specific activity [{sup 11}C]O{sub 2}

Description: In the routine preparation of {sup 11}C-labeled compounds through N-[{sup 11}C]-methylation using [{sup 11}C]H{sub 3}I, total masses are always higher than synthesis mass contribution, suggesting that the target system contributes carrier carbon to the final product mass. This conclusion prompted this evaluation of target materials and target design for [{sup 11}C]O{sub 2} production. Ultimately, one is faced with the sprospect of compromising between [{sup 11}C]O{sub 2} specific activity and the amount that can be extracted from the target after a reasonable irradiation time.
Date: December 31, 1993
Creator: Ferrieri, R. A.; Alexoff, D. L.; Schlyer, D. J.; McDonald, K. & Wolf, A. P.
Partner: UNT Libraries Government Documents Department

Discussion of possible content of an IAEA (International Atomic Energy Agency) handbook/computer file for ''Data for Medical Radioisotope Production''

Description: Several possible approaches will be put forward in order to stimulate discussion and seek consensus on the relative emphasis and format of a proposed IAEA handbook and computer file for ''Data for Medical Radioisotope Production.'' An outline for possible chapters for non-nuclear physicists will be presented describing low, medium, and high energy reactions induced by light projectiles (e.g., n,p,..cap alpha..), by photons, and by heavy ions. Qualitative features would be described, typical experimental examples would be presented to illustrate each type of reaction, and examples would be presented of how well various computer codes would permit the calculation/prediction of the experimental results. We next solicit discussion of the desirability of the above, and of the format and means of compilation of a computer data file for isotope production. This should include format of experimental data, and also, whether a calculated file should be presented for production of particular isotopes from a ''most wanted'' list.
Date: April 1, 1987
Creator: Blann, M.
Partner: UNT Libraries Government Documents Department