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Quantitative representation of three-dimensional cell culturemodels

Description: Three-dimensional mammary cell culture models offer new opportunities for the development of computational techniques for segmentation, localization, and multicellular organization. Under normal conditions, these assays form a symmetrical, hollow structure, which is necessary for their functional operation. Often, the nuclear compartments are labeled, which provides context for quantitative protein localization or colony structure through fluorescent microscopy. These colonies are first delinea… more
Date: February 1, 2007
Creator: Chang, Hang; Park, Catherine & Parvin, Bahram
Partner: UNT Libraries Government Documents Department
open access

Environmental Biosciences Program Report for Year Three

Description: In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are c… more
Date: July 31, 2006
Creator: Mohr, Lawrence C.
Partner: UNT Libraries Government Documents Department
open access

Environmental Biosciences Program Quarterly Report for Year 3

Description: In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are c… more
Date: April 30, 2006
Creator: Mohr, Lawrence C.
Partner: UNT Libraries Government Documents Department
open access

Environmental Biosciences Program Quarterly Report

Description: In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are c… more
Date: October 31, 2006
Creator: Mohr, Lawrence C.
Partner: UNT Libraries Government Documents Department
open access

Use of Computational Modeling to Evaluate Hypotheses About the Molecular and Cellular Mechanisms of Bystander Effects

Description: This report describes the development of a computational systems biology approach to evaluate the hypotheses of molecular and cellular mechanisms of adaptive response to low dose ionizing radiation. Our concept is that computational models of signaling pathways can be developed and linked to biologically based dose response models to evaluate the underlying molecular mechanisms which lead to adaptive response. For development of quantitatively accurate, predictive models, it will be necessary t… more
Date: November 21, 2006
Creator: Zhao, Yuchao; Conolly, Rory B & Andersen, Melvin E.
Partner: UNT Libraries Government Documents Department
open access

RBE of Monoenergetic Fast Neutrons: Cytogenetic Effects in Maize

Description: Investigations on the relative biological effectiveness (RBE) of densely ionizing radiations (with high LET, rate of linear energy transfer) are of importance in both fundamental and applied radiobiology. In the latter, they serve as a basis in setting permissible exposure levels for types of radiation about which little long range experience is available. Some of the best RBE studies have been done on chromosomal aberrations. The difficulty is determining RBE on the basis of chromosomal exchan… more
Date: November 13, 1963
Creator: Smith, H. H.; Bateman, J. L.; Quastler, H. & Rossi, H. H.
Partner: UNT Libraries Government Documents Department
open access

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease

Description: Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with uni… more
Date: June 6, 2008
Creator: Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco & Wyrobek, Andrew J.
Partner: UNT Libraries Government Documents Department
open access

Environmental Biosciences Program Quarterly Report

Description: In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are c… more
Date: January 31, 2008
Creator: Mohr, Lawrence C.
Partner: UNT Libraries Government Documents Department
open access

Development of Nanostructured Materials with Improved Radiation Tolerance for Advanced Nuclear Systems

Description: This project will explore the fundamental mechanisms through which interfaces in nanolayered structures and grain boundaries of bulk nanomaterials are able to attract and rapidly eliminate point defects and unwanted foreign species. Candidate materials that will be studied include both nanostructured multilayer composites synthesized by magnetron sputtering and structural bulk nanomaterials produced by severed plastic deformation, equal channel angular extrusion.
Date: August 12, 2009
Creator: Zhang, Zinghang & Hartwig, K. Ted
Partner: UNT Libraries Government Documents Department
open access

Environmental Biosciences Program Fourth Quarter Report

Description: In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are c… more
Date: June 30, 2005
Creator: Mohr, Lawrence C.
Partner: UNT Libraries Government Documents Department
open access

Environmental Biosciences Program Third Quarter Report, Year 2

Description: In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are c… more
Date: March 31, 2005
Creator: Mohr, Lawrence C.
Partner: UNT Libraries Government Documents Department
open access

Environmental Biosciences Program Second Quarter Report

Description: In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are c… more
Date: December 31, 2004
Creator: Mohr, Lawrence C.
Partner: UNT Libraries Government Documents Department
open access

Measurement of the radiation field surrounding the Collider Detector at Fermilab

Description: We present here the first direct and detailed measurements of the spatial distribution of the ionizing radiation surrounding a hadron collider experiment. Using data from two different exposures we measure the effect of additional shielding on the radiation field around the Collider Detector at Fermilab (CDF). Employing a simple model we parameterize the ionizing radiation field surrounding the detector.
Date: January 28, 2004
Creator: al., K. Kordas et
Partner: UNT Libraries Government Documents Department
open access

A MODULAR ACTUATOR ARCHITECTURE FOR ROBOTIC APPLICATIONS

Description: The United States Department of Energy (DOE) Complexes perform numerous hazardous material handling operations within the confines of a glovebox. The DOE is continuing to seek more efficient and safer means of handling these materials inside gloveboxes rather than the conventional, labor-intensive method through lead lined gloves. The use of glovebox automation technology will also be critical to the DOE in its efforts to comply with its mandated ALARA principles in handling the hazardous mater… more
Date: July 1, 2001
Partner: UNT Libraries Government Documents Department
open access

Environmental Biosciences Quarterly Report, September - December, 2005

Description: In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are c… more
Date: January 31, 2006
Creator: Mohr, Lawrence C.
Partner: UNT Libraries Government Documents Department
open access

Environmental Biosciences Program Quarterly Report

Description: In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are c… more
Date: July 31, 2007
Creator: Mohr, Lawrence C.
Partner: UNT Libraries Government Documents Department
open access

Final report of the Committee on Interagency Radiation Research and Policy Coordination, 1984-1995

Description: This document is the final report of the Committee on Interagency Radiation Research and Policy Coordination (CIRRPC). The committee was established to address national and international issues involving ionizing and nonionizing radiation. Three sections are included in the report: a summary of CIRRPC`s history structure, and operations; CIRRPC`s most significant activities, findings and recommendations on national radiation issues of sufficient importance and scope to require interagency atten… more
Date: September 1, 1995
Partner: UNT Libraries Government Documents Department
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Repair of radiation-induced heat-labile sites is independent of DNA-PKcs, XRCC1 or PARP

Description: Ionizing radiation induces a variety of different DNA lesions: in addition to the most critical DNA damage, the DSB, numerous base alterations, SSBs and other modifications of the DNA double-helix are formed. When several non-DSB lesions are clustered within a short distance along DNA, or close to a DSB, they may interfere with the repair of DSBs and affect the measurement of DSB induction and repair. We have previously shown that a substantial fraction of DSBs measured by pulsed-field gel elec… more
Date: April 29, 2008
Creator: Stenerlöw, Bo; Karlsson, Karin H.; Radulescu, Irina; Rydberg, Bjorn & Stenerlow, Bo
Partner: UNT Libraries Government Documents Department
open access

Numerical Simulation of Table-Top Tunable Smith-Purcell Teraherz Free-Electron Laser Operating in the Superradiant Regime

Description: Terahertz (THz) radiation occupies a very large portion of the electromagnetic spectrum and has generated much recent interest due to its ability to penetrate deep into many organic materials without the damage associated with ionizing radiation such as x-rays. One path for generating copious amount of tunable narrow-band THz radiation is based on the Smith-Purcell free-electron laser (SPFEL) effect. In this Letter we propose a simple concept for a compact tunable SPFEL operating in the superra… more
Date: January 1, 2010
Creator: Prokop, C.; Piot, P.; Lin, M.C.; Stoltz, P. & U., /Fermilab /Northern Illinois
Partner: UNT Libraries Government Documents Department
open access

Environmental Biosciences First Quarter Report

Description: In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives… more
Date: September 30, 2003
Creator: Mohr, Lawrence C.
Partner: UNT Libraries Government Documents Department
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