18 Matching Results

Search Results

Advanced search parameters have been applied.
in subjects: "Hela Cells"  
Results: 1 - 18
open access

Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector

Description: Article on synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector.
Date: July 11, 2011
Creator: Harris, Alesha N.; Hinojosa, Barbara R.; Chavious, Montaleé D. & Petros, Robby A.
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
open access

Fox-2 Splicing Factor Binds to a Conserved Intron Motif to PromoteInclusion of Protein 4.1R Alternative Exon 16

Description: Activation of protein 4.1R exon 16 (E16) inclusion during erythropoiesis represents a physiologically important splicing switch that increases 4.1R affinity for spectrin and actin. Previous studies showed that negative regulation of E16 splicing is mediated by the binding of hnRNP A/B proteins to silencer elements in the exon and that downregulation of hnRNP A/B proteins in erythroblasts leads to activation of E16 inclusion. This paper demonstrates that positive regulation of E16 splicing can b… more
Date: March 1, 2006
Creator: Ponthier, Julie L.; Schluepen, Christina; Chen, Weiguo; Lersch,Robert A.; Gee, Sherry L.; Hou, Victor C. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Changes in gene expression following EMF exposure

Description: Experiments were designed to examine the effects of electromagnetic field (EMF) exposure on specific gene expression, an effect that can be deleterious, beneficial, or neutral, depending on the long-term consequences; however, the proof of a reproducible, quantitative biological effect (such as change in gene expression) will lead to latter experiments aimed at determining the relative contribution of these changes to cellular consequences. Past work by ourselves and by others has shown that me… more
Date: October 1, 1997
Creator: Woloschak, Gayle E.; Paunesku, Tatjana; Chang-Liu, Chin-Mei; Loberg, Lise; Gauger, James & McCormick, David
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

HIV transcription is induced in dying cells

Description: Using HeLa cells stably transfected with an HIV-LTR-CAT construct, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires functional p53, which is not present in HeLa cells. For all other agents, HIV-LTR induction wa… more
Date: February 1, 1996
Creator: Woloschak, Gayle E.; Chang-Liu, Chin-Mei; Schreck, Steven; Panozzo, John & Libertin, Claudia R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

CD147 is a regulatory subunit of the gamma-secretase complex inAlzheimer's disease amyloid beta-peptide production

Description: {gamma}-secretase is a membrane protein complex that cleaves the {beta}-amyloid precursor protein (APP) within the transmembrane region, following prior processing by {beta}-secretase, producing amyloid {beta}-peptides (A{beta}{sub 40} and A{beta}{sub 42}). Errant production of A{beta}-peptides that substantially increases A{beta}{sub 42} production has been associated with the formation of amyloid plaques in Alzheimer's disease patients. Biophysical and genetic studies indicate that presenilin… more
Date: April 6, 2005
Creator: Zhou, Shuxia; Zhou, Hua; Walian, Peter J. & Jap, Bing K.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

The effects of 5-fluorouracil and doxorubicin on expression of human immunodeficiency virus type 1 long terminal repeat

Description: Previous work by many groups has documented induction of the HIV-LTR following exposure of cells to ultraviolet light and other DNA damaging agents. Our experiments set out to determine the relative activation or repression of the HIV-LTR in response to two classes of chemotherapeutic agents: Doxorubicin is a DNA-damage inducing agent, and 5-fluorouracil has an antimetabolic mode of action. Using HeLa cells stably transfected with a construct in which HIV-LTR drives expression of the chloramphe… more
Date: March 1996
Creator: Panozzo, J.; Akan, E.; Griffiths, T. D. & Woloschak, G. E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Biological Applications and Transmission Electron Microscopy Investigations of Mesoporous Silica Nanoparticles

Description: The research presented and discussed within involves the development of novel biological applications of mesoporous silica nanoparticles (MSN) and an investigation of mesoporous material by transmission electron microscopy (TEM). Mesoporous silica nanoparticles organically functionalized shown to undergo endocytosis in cancer cells and drug release from the pores was controlled intracellularly and intercellularly. Transmission electron microscopy investigations demonstrated the variety of morph… more
Date: May 1, 2006
Creator: Trewyn, Brian G.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries Government Documents Department
open access

HIV transcription is induced in dying cells

Description: Using HeLa cells stably transfected with an HIV-LTR-CAT construct, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires functional p53, which is not present in HeLa cells. For all other agents, HIV-LTR induction wa… more
Date: June 1, 1995
Creator: Woloschak, Gayle E.; Chang-Liu, Chin-Mei; Schreck, Steven; Panozzo, John & Libertin, Claudia R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Main research accomplishments during the past three-year period, [December 1, 1985--November 30, 1988]

Description: We have purified HeLa DNA polymerase {var_epsilon} (pol {var_epsilon}), showed it to be a unique and newly-described DNA polymerase, and modified our permeabilized cell assay accordingly. We partially purified correcting factors for Xeroderma Pigmentosum (XP) XP-A and E. We showed that a DNA binding protein is absent from two XP-E cell lines, but normal in others. We purified and characterized UV indoor III, a correcting factor for XP-D. We finished our characterization of mammalian UV endos I … more
Date: December 31, 1991
Creator: Linn, S. M.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The molecular basis for uv response of cultured human cells

Description: During the past year we have analyzed the mechanism by which UV and H{sub 2}O{sub 2} increase the activity of AP-1 in HeLa cells. AP-1 is a dimeric protein complex composed of the fos and jun gene products. After UV irradiation of HeLa cells (or exposure to H{sub 2}O{sub 2}) expression of the c-jun gene rapidly increases at least 50-fold. This induction occurs through the previously identified AP-1 site in the c-jun promoter. This positive autoregulation is mediated by AP-1 complexes that are c… more
Date: December 1, 1991
Creator: Karin, M.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Uptake and fate of ouabain bound to HeLa cells. [/sup 3/H tracer study]

Description: The first step in the pharmacologic interaction of a cardiac glycoside with cells is the binding of the drug to its specific surface receptor, an exteriorly oriented site of the Na/sup +/--K/sup +/ ATPase. The purpose of the study outlined was to follow a glycoside from its initial binding to its ultimate release from a sensitive cell, and in parallel studies to observe the recovery of the cells from glycoside intoxication. The glycoside used is /sup 3/H-ouabain, and the cells are from the S3 c… more
Date: January 1, 1977
Creator: Cook, J. S. & Brake, E. T.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Rad51C deficiency destabilizes XRCC3, impairs recombination and radiosensitizes S/G2-phase cells

Description: The highly conserved Rad51 protein plays an essential role in repairing DNA damage through homologous recombination. In vertebrates, five Rad51 paralogs (Rad51B, Rad51C, Rad51D, XRCC2, XRCC3) are expressed in mitotically growing cells, and are thought to play mediating roles in homologous recombination, though their precise functions remain unclear. Here we report the use of RNA interference to deplete expression of Rad51C protein in human HT1080 and HeLa cells. In HT1080 cells, depletion of Ra… more
Date: May 1, 2004
Creator: Lio, Yi-Ching; Schild, David; Brenneman, Mark A.; Redpath, J. Leslie & Chen, David J.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Biological effects of $sup 252$Cf neutrons

Description: From second meeting on fundamental and practical aspects of the application of fast neutrons in clinical radiotherapy; The Hague, Netherlands (3 Oct 1973). The biological effects of /sup 252/Cf neutrons were studied with cultured cells, and with intact tissues. Measurements available to date, of the relative biological effect (RBE) and of the oxygen enhancement ratio (OER), are summarized and discussed. A table is presented to show the RBE of /sup 252/Cf neutrons, compared to /sup 137/Cs or /su… more
Date: January 1, 1973
Creator: Fairchild, R.G.; Atkins, H.L.; Drew, R.M. & Robertson, J.S.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

The molecular basis for uv response of cultured human cells

Description: During the past year we have analyzed the mechanism by which UV and H{sub 2}O{sub 2} increase the activity of AP-1 in HeLa cells. AP-1 is a dimeric protein complex composed of the fos and jun gene products. After UV irradiation of HeLa cells (or exposure to H{sub 2}O{sub 2}) expression of the c-jun gene rapidly increases at least 50-fold. This induction occurs through the previously identified AP-1 site in the c-jun promoter. This positive autoregulation is mediated by AP-1 complexes that are c… more
Date: January 1, 1991
Creator: Karin, M.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
Back to Top of Screen