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Enzymatic Upgrading of Heavy Crudes via Partial Oxidation or Conversion of PAHs

Description: The objective of this program was to investigate new enzyme-based technologies for upgrading of heavy oils. Enzymes were selected for screening from those capable of conversion of polyaromatic hydrocarbons (PAHs) reported in the literature. Oxidative reactions of PAHs using hydrogen peroxide as an oxidant with conversion to partially oxidized products were used. The enzymes (lignin peroxidase, cytochrome c) were tested in various organic solvents and found to loose activity in pure organic solv… more
Date: July 1, 2002
Creator: Borole, A. P.; Davison, B. H. & Kuritz, T.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Disruption of NBS1 gene leads to early embryonic lethality in homozygous null mice and induces specific cancer in heterozygous mice

Description: Nijmegen breakage syndrome (NBS) is a rare autosomal recessive chromosome instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition, with cellular features similar to that of ataxia telangiectasia (AT). NBS results from mutations in the mammalian gene Nbs1 that codes for a 95-kDa protein called nibrin, NBS1, or p95. To establish an animal model for NBS, we attempted to generate NBS1 knockout mice. However, NBS1 gene knockouts were lethal… more
Date: April 15, 2002
Creator: Kurimasa, Akihiro; Burma, Sandeep; Henrie, Melinda; Ouyang, Honghai; Osaki, Mitsuhiko; Ito, Hisao et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Global Expression Studies of Yersinia Pestis Pathogenicity

Description: The aim of these studies continues to be the investigation into the molecular mechanisms that underlie the virulence process in Yersinia pestis. In particular, the focus of this work centers on the identification of novel genes and pathways responsible for the pathogenic properties of this organism. In spite of more than four decades of intense investigation in this field, the dilemma as to what makes Y. pestis such a virulent and lethal pathogen remains unanswered. The method being employed ma… more
Date: October 15, 2002
Creator: Garcia, E; Motin, V; Brubaker, R & Fitch, P
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The complete mitochondrial sequence of the"living fossil" Tricholepidion gertschi: structure, phylogenetic implications, and the description of a novel A/T asymmetrical bias

Description: Traditionally, the 'Apterygota' has been thought to consist of five orders of wingless hexapods (Protura, Collembola, Diplura, Microcoryphia and Zygentoma) believed to be collectively basal to insects (i.e., the Pterygota). However, some studies have questioned this affinity with insects (Dallai, Abele, Spears, Nardi). Further, within these groups are hotly debated issues, including the monophyly of Entognata (Koch, 1997; Kukalova Peck, 1987), the monophyly of Diplura (Bilinski, 1993; Stys and … more
Date: June 23, 2002
Creator: Nardi, F.; Frati, F.; Carapelli, A.; Dallai, R. & Boore, J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

DNA Dilemma: A Perspective on Current U.S. Patent and Trademarh Office Philosophy Concerning Life Patents

Description: The lack of a solid set of criteria for determining patentability of subject matter - particularly subject matter dealing with life - has recently been of increasing public concern in the United States. Alarm for patent practices related to life systems ranges from patents being granted on biochemical processes and the knowledge of these processes to the patenting of entire organisms. One of the most volatile concerns is the patenting of human genes or parts of genes since this genetic material… more
Date: January 1, 2002
Creator: Franz, Kale & Faletra, Peter
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Molecular and Genetic Analysis of Hormone-Regulated Differential Cell Elongation in Arabidopsis

Description: The authors have utilized the response of Arabidopsis seedlings to the plant hormone ethylene to identify new genes involved in the regulation of ethylene biosynthesis, perception, signal transduction and differential cell growth. In building a genetic framework for the action of these genes, they developed a molecular model that has facilitated the understanding of the molecular requirements of ethylene for cell elongation processes. The ethylene response pathway in Arabidopsis appears to be p… more
Date: December 3, 2002
Creator: Ecker, Joseph R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Salmonid Gamete Preservation in the Snake River Basin, 2001 Annual Report.

Description: Steelhead (Oncorhynchus mykiss) and chinook salmon (Oncorhynchus tshawytscha) populations in the Northwest are decreasing. Genetic diversity is being lost at an alarming rate. Along with reduced population and genetic variability, the loss of biodiversity means a diminished environmental adaptability. The Nez Perce Tribe (Tribe) strives to ensure availability of genetic samples of the existing male salmonid population by establishing and maintaining a germplasm repository. The sampling strategy… more
Date: June 1, 2002
Creator: Armstrong, Robyn & Kucera, Paul
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The organizing principle: microenvironmental influences in the normal and malignant breast

Description: The current paradigm for cancer initiation and progression rests on the groundbreaking discoveries of oncogenes and tumor suppressor genes. This framework has revealed much about the role of genetic alterations in the underlying signaling pathways central to normal cellular function and to tumor progression. However, it is clear that single gene theories or even sequential acquisition of mutations underestimate the nature of the genetic and epigenetic changes in tumors, and do not account for t… more
Date: August 20, 2002
Creator: Bissell, Mina; Radisky, Derek C.; Rizki, Aylin; Weaver, Valerie M. & Petersen, Ole W.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Building beauty: the genetic control of floral patterning

Description: OAK-B135 Floral organ identity is controlled by combinatorial action of homeotic genes expressed in different territories within the emerging flower. This review discusses recent progress in our understanding of floral homeotic genes, with an emphasis on how their region-specific expression is regulated.
Date: February 1, 2002
Creator: Lohmann, J. U. & Weigel, D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Genetic Construction of Truncated and Chimeric Metalloproteins Derived from the Alpha Subunit of Acetyl-CoA Synthase from Clostridium thermoaceticum

Description: In this study, a genetics-based method is used to truncate acetyl-coenzyme A synthase from Clostridium thermoaceticum (ACS), an alpha2beta2 tetrameric 310 kda bifunctional enzyme. ACS catalyzes the reversible reduction of CO2 to CO and the synthesis of acetyl-CoA from CO (or CO2 in the presence of low-potential reductants), CoA, and a methyl group bound to a corrinoid-iron sulfur protein (CoFeSP). ACS contains 7 metal-sulfur clusters of 4 different types called A, B, C, and D. The B, C, and D c… more
Date: June 28, 2002
Creator: Loke, Huay-Keng; Tan, Xiangshi & Lindahl, Paul A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Chlorinated Hydrocarbon Degradation in Plants: Mechanisms and Enhancement of Phytoremediation of Groundwater Contamination

Description: Several varieties of transgenic poplar containing cytochrome P-450 2E1 have been constructed and are undergoing tests. Strategies for improving public acceptance and safety of transgenic poplar for chlorinated hydrocarbon phytoremediation are being developed. We have discovered a unique rhizobium species that lives within the stems of poplar and we are investigating whether this bacterium contributes nitrogen fixed from the air to the plant and whether this endophyte could be used to introduce … more
Date: June 1, 2002
Creator: Strand, Stuart E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Phytoremediation of ionic and methylmercury pollution

Description: Our long-term objective is to enable highly productive plant species to extract, resist, detoxify, and/or sequester toxic organic and heavy metal pollutants (Meagher, 2000) applying scientific strategies and technologies from a rapidly developing field called phytoremediation. The phytoremediation of toxic elemental and organic pollutants requires the use relatively different approaches (Meagher, 2000). Our current specific objectives are to use transgenic plants to control the chemical species… more
Date: June 1, 2002
Creator: Meagher, Richard B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Mechanisms and Determinants of RNA Turnover: Plant IRESs and Polycistrons for Metabolic Engineering

Description: There is a strong need for tools that allow multiple transgenes to be expressed in genetically engineered plants. For the last 30 years it has been believed that nearly all eukaryotic mRNAs were monocistronic, with ribosomes entering at the 5' end and scanning through the 5'UTR to the first AUG codon. It is now clear that perhaps 3% of vertebrate and yeast mRNAs utilize IRESs (Internal Ribosome Entry Sites) within their 5'UTRs to promote the internal entry of ribosomes to mRNAs and subsequent t… more
Date: August 1, 2002
Creator: Meagher, Richard B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Analysis of Gene Targeting & Nonhomologous End-joining. Final Report

Description: Overall, we identified a number of new proteins that participate in nonhomologous end-joining and also in telomere addition to the ends of broken chromosomes. We showed that NHEJ is severely reduced in cells expressing both yeast mating-type genes and then went on to identify the NEJ1 gene that was under this control. We showed the epistasis relations among a set of mutations that impair telomere addition and we showed that there are in fact two pathways to repair broken chromosomes in the abse… more
Date: November 30, 2002
Creator: Haber, J. E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

SNPs in putative regulatory regions identified by human mouse comparative sequencing and transcription factor binding site data

Description: Genome wide disease association analysis using SNPs is being explored as a method for dissecting complex genetic traits and a vast number of SNPs have been generated for this purpose. As there are cost and throughput limitations of genotyping large numbers of SNPs and statistical issues regarding the large number of dependent tests on the same data set, to make association analysis practical it has been proposed that SNPs should be prioritized based on likely functional importance. The most eas… more
Date: January 1, 2002
Creator: Banerjee, Poulabi; Bahlo, Melanie; Schwartz, Jody R.; Loots, Gabriela G.; Houston, Kathryn A.; Dubchak, Inna et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

QTL and Candidate Genes for Growth Traits in Pinus Taeda L

Description: The reason for the project is to find the genetic factors which control growth at ages closer to commercial harvest (also known as QTL detection). To date, efforts to find genetic factors which control growth have been limited to seedlings. Because tree breeders want to find molecular markers which are linked to traits of direct economic value, finding linkage to factors controlling older-tree growth is more critical than seedling growth. Our current research interest includes both absolute hei… more
Date: 2002-10~
Creator: Williams, Claire G.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Activities of Human Gene Nomenclature Committee

Description: The objective of this project, shared between NIH and DOE, has been and remains to enable the medical genetics communities to use common names for genes that are discovered by different gene hunting groups, in different species. This effort provides consistent gene nomenclature and approved gene symbols to the community at large. This contributes to a uniform and consistent understanding of genomes, particularly the human as well as functional genomics based on comparisons between homologous ge… more
Date: July 16, 2002
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Final report: FASEB Summer Research Conference on ''Post-transcriptional control of gene expression: Effectors of mRNA decay'' [agenda and attendees list]

Description: The goal of this meeting was to provide an interactive forum for scientists working on prokaryotic and eukaryotic mRNA decay. A special seminar presented by a leader in the field of mRNA decay in S. cerevisiae focused on what is known and what needs to be determined, not only for yeast but for other organisms. The large attendance (110 participants) reflects the awareness that mRNA decay is a key player in gene regulation in a way that is affected by the many steps that precede mRNA formation. … more
Date: December 1, 2002
Creator: Maquat, Lynne
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Time-Resolved Sequence Analysis on High Density Fiberoptic DNA Probe

Description: A universal array format has been developed in which all possible n-mers of a particular oligonucleotide sequence can be represented. The ability to determine the sequence of the probes at every position in the array should enable unbiased gene expression as well as arrays for de novo sequencing.
Date: November 19, 2002
Creator: Walt, D. R. & Lee, K. H.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Sucrose-mediated transcriptional regulation of sucrose symporter activity in the phloem.

Description: This project was based on our discovery that sucrose acts as a signaling molecule that regulates the activity of a proton-sucrose symporter in sugar beet leaf tissue. A major objective here was determining how sucrose transporter activity is being regulated. When sucrose accumulates in the phloem sucrose transport activity drops dramatically. Western blots of plasma membrane proteins isolated from sucrose treated leaves showed that the loss of sucrose transport activity was proportional to a de… more
Date: August 6, 2002
Creator: Vaughn, Matt; Harrington, Greg & Bush, Daniel R.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Cyr61 promotes breast tumorigenesis and cancer progression

Description: Cyr61, a member of the CCN family of genes, is an angiogenic factor. We have shown that it is overexpressed in invasive and metastatic human breast cancer cells and tissues. Here, we investigated whether Cyr61 is necessary and/or sufficient to bypass the ''normal'' estrogen (E2) requirements for breast cancer cell growth. Our results demonstrate that under E2-depleted condition, Cyr61 is sufficient to induce MCF-7 cells grow in the absence of E2. MCF-7 cells transfected with Cyr61 (MCF-7/Cyr61)… more
Date: January 16, 2002
Creator: Tsai, Miaw-Sheue; Bogart, Daphne F.; Castaneda, Jessica M.; Li, Patricia & Lupu, Ruth
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Ethical and legal issues arising from complex genetic disorders. DOE final report

Description: The project analyzed the challenges raised by complex genetic disorders in genetic counselling, for clinical practice, for public health, for quality assurance, and for protection against discrimination. The research found that, in some settings, solutions created in the context of single gene disorders are more difficult to apply to complex disorders. In other settings, the single gene solutions actually backfired and created additional problems when applied to complex genetic disorders. The l… more
Date: October 9, 2002
Creator: Andrews, Lori
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Genetic Polymorphism in Three Glutathione S-Transferase Genes and Breast Cancer Risk

Description: The role of the glutathione S-transferase (GST) enzyme family is to detoxify environmental toxins and carcinogens and to protect organisms from their adverse effects, including cancer. The genes GSTM1, GSTP1, and GSTT1 code for three GSTs involved in the detoxification of carcinogens, such as polycyclic aromatic hydrocarbons (PAHs) and benzene. In humans, GSTM1 is deleted in about 50% of the population, GSTT1 is absent in about 20%, whereas the GSTP1 gene has a single base polymorphism resultin… more
Date: April 1, 2002
Creator: Woldegiorgis, S.; Ahmed, R. C.; Zhen, Y.; Erdmann, C. A.; Russell, M. L. & Goth-Goldstein, R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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