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Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol

Description: BackgroundIncreasing energy costs and environmental concerns have motivated engineering microbes for the production of ?second generation? biofuels that have better properties than ethanol.Results& ConclusionsSaccharomyces cerevisiae was engineered with an n-butanol biosynthetic pathway, in which isozymes from a number of different organisms (S. cerevisiae, Escherichia coli, Clostridium beijerinckii, and Ralstonia eutropha) were substituted for the Clostridial enzymes and their effect on n-… more
Date: November 25, 2008
Creator: Steen, EricJ.; Chan, Rossana; Prasad, Nilu; Myers, Samuel; Petzold, Christopher; Redding, Alyssa et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Functional analysis of U1-70K interacting SR proteins in pre-mRNA splicing in Arabidopsis

Description: Proteins of a serine/arginine-rich (SR) family are part of the spliceosome and are implicated in both constitutive and alternative splicing of pre-mRNAs. With the funding from DOE we have been studying alternative of splicing of genes encoding serine/arginine-rich (SR) proteins and the roles of SR proteins that interact with U1-70K in regulating basic and alternative splicing. Alternative splicing of pre-mRNAs of Arabidopsis serine/arginine-rich proteins and its regulation by hormones and stres… more
Date: November 25, 2008
Creator: Reddy, A.S.N.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Visualization and Analysis of 3D Gene Expression Data

Description: Recent methods for extracting precise measurements ofspatial gene expression patterns from three-dimensional (3D) image dataopens the way for new analysis of the complex gene regulatory networkscontrolling animal development. To support analysis of this novel andhighly complex data we developed PointCloudXplore (PCX), an integratedvisualization framework that supports dedicated multi-modal, physical andinformation visualization views along with algorithms to aid in analyzingthe relationships be… more
Date: October 25, 2007
Creator: Bethel, E. Wes; Rubel, Oliver; Weber, Gunther H.; Hamann, Bernd & Hagen, Hans
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Workshop on ENU Mutagenesis: Planning for Saturation, July 25-28, 2002

Description: The goal of the conference is to enhance the development of improved technologies and new approaches to the identification of genes underlying chemically-induced mutant phenotypes. The conference brings together ENU mutagenesis experts from the United States and aborad for a small, intensive workshop to consider these issues.
Date: July 25, 2002
Creator: Nadeau, Joseph H
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

A phylogenomic gene cluster resource: The phylogeneticallyinferred groups (PhlGs) database

Description: We present here the PhIGs database, a phylogenomic resource for sequenced genomes. Although many methods exist for clustering gene families, very few attempt to create truly orthologous clusters sharing descent from a single ancestral gene across a range of evolutionary depths. Although these non-phylogenetic gene family clusters have been used broadly for gene annotation, errors are known to be introduced by the artifactual association of slowly evolving paralogs and lack of annotation for tho… more
Date: August 25, 2005
Creator: Dehal, Paramvir S. & Boore, Jeffrey L.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

IMG ER: A System for Microbial Genome Annotation Expert Review and Curation

Description: A rapidly increasing number of microbial genomes are sequenced by organizations worldwide and are eventually included into various public genome data resources. The quality of the annotations depends largely on the original dataset providers, with erroneous or incomplete annotations often carried over into the public resources and difficult to correct. We have developed an Expert Review (ER) version of the Integrated Microbial Genomes (IMG) system, with the goal of supporting systematic and eff… more
Date: May 25, 2009
Creator: Markowitz, Victor M.; Mavromatis, Konstantinos; Ivanova, Natalia N.; Chen, I-Min A.; Chu, Ken & Kyrpides, Nikos C.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Final report - Microbial pathways for the reduction of mercury in saturated subsurface sediments

Description: Mercury is a component of mixed wastes that have contaminated vast areas of the deep subsurface as a result of nuclear weapon and energy production. While this mercury is mostly bound to soil constituents episodes of groundwater contamination are known in some cases resulting in potable water super saturated with Hg(0). Microbial processes that reduce Hg(II) to the elemental form Hg(0) in the saturated subsurface sediments may contribute to this problem. When we started the project, only one mi… more
Date: August 25, 2009
Creator: barkay, Tamar; Young, Lily & Zylstra, Gerben
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

Description: Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is the site of several oncogenes, including the eukaryotic elongation factor EEF1A2 and the transcription factor ZNF217. We reported previously that overexpressed ZNF217 induces neoplastic characteristics in precursor cells of OEC. Unexpectedly, ZNF217, which is a transcriptional repressor, enhanced expression of eEF1A2. In this study, array comparative genomic hybridization, single nucleotide polymor… more
Date: April 25, 2008
Creator: Sun, Yu; Wong, Nicholas; Guan, Yinghui; Salamanca, Clara M.; Cheng, Jung Chien; Lee, Jonathan M. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Development of Biomarkers for Chronic Beryllium Disease in Mice

Description: Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an anima… more
Date: January 25, 2013
Creator: Gordon, Terry
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Genomic sequence of the xylose fermenting, insect-inhabitingyeast, Pichia stipitis

Description: Xylose is a major constituent of angiosperm lignocellulose,so its fermentation is important for bioconversion to fuels andchemicals. Pichia stipitis is the best-studied native xylose fermentingyeast. Genes from P. stipitis have been used to engineer xylosemetabolism in Saccharomycescerevisiae, and the regulation of the P.stipitis genome offers insights into the mechanisms of xylose metabolismin yeasts. We have sequenced, assembled and finished the genome ofP.stipitis. As such, it is one of only… more
Date: June 25, 2007
Creator: Jeffries, Thomas W.; Grigoriev, Igor; Grimwood, Jane; Laplaza,Jose M.; Aerts, Andrea; Salamov, Asaf et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Complete Genome Sequence of Denitrovibrio Acetiphilus Type Strain (N2460T)

Description: Denitrovibrio acetiphilus Myhr and Torsvik 2000 is the type species of the genus Denitrovibrio in the bacterial family Deferribacteraceae. It is of phylogenetic interest because there are only six genera described in the family Deferribacteraceae. D. acetiphilus was isolated as a representative of a population reducing nitrate to ammonia in a laboratory column simulating the conditions in off-shore oil recovery fields. When nitrate was added to this column undesirable hydrogen sulfide productio… more
Date: June 25, 2010
Creator: Kiss, Hajnalka; Lang, Elke; Lapidus, Alla; Copeland, Alex; Nolan, Matt; Glavina Del Rio, Tijana et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Complete Genome Sequence of Coraliomargarita Akajimensis Type Strain (04OKA010-24T)

Description: Coraliomargarita akajimensis Yoon et al. 2007 the type species of the genus Coraliomargarita. C. akajimensis is an obligately aerobic, Gram-negative, non-spore-forming, non-motile, spherical bacterium which was isolated from seawater surrounding the hard coral Galaxea fascicularis. C. akajimensis organism is of special interest because of its phylogenetic position in a genomically purely studied area in the bacterial diversity. Here we describe the features of this organism, together with the… more
Date: June 25, 2010
Creator: Mavromatis, Konstantinos; Abt, Birte; Brambilla, Evelyne; Lapidus, Alla; Copeland, Alex; Desphande, Shweta et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Gene expression profiles of Nitrosomonas europaea, an obligate chemolitotroph

Description: Nitrosomonas europaea is an aerobic lithoautotrophic bacterium that uses ammonia (NH3) as its energy source. As a nitrifier, it is an important participant in the nitrogen cycle, which can also influence the carbon cycle. The focus of this work was to explore the genetic structure and mechanisms underlying the lithoautotrophic growth style of N. europaea. Whole genome gene expression: The gene expression profile of cells in exponential growth and during starvation was analyzed using microarrays… more
Date: May 25, 2005
Creator: Arp, Daniel J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Development of innovative techniques and principles that may be used as models to improve plant performance. Final report

Description: We developed fundamental methods and techniques for transferring germplasm from wild to cultivated species. Germplasm transferred included diverse cytoplasms, new genes for pest resistance, genes controlling dry matter yield and apomixis. Some of the germplasm has been shown to be valuable in plant breeding and has been incorporated into commercial cultivators.
Date: June 25, 2000
Creator: Hanna, Wayne W. & Burton, Glenn W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

The Expression Level of HJURP has an Independent Prognostic Impact and Predicts the Sensitivity to Radiotherapy in Breast Cancer

Description: Introduction: HJURP (Holliday Junction Recognition Protein) is a newly discovered gene reported to function at centromeres and to interact with CENPA. However its role in tumor development remains largely unknown. The goal of this study was to investigate the clinical significance of HJURP in breast cancer and its correlation with radiotherapeutic outcome. Methods: We measured HJURP expression level in human breast cancer cell lines and primary breast cancers by Western blot and/or by Affymetri… more
Date: June 25, 2010
Creator: Hu, Zhi; Huang, Ge; Sadanandam, Anguraj; Gu, Shenda; Lenburg, Marc E.; Pai, Melody et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
captions transcript

[News Clip: Designer genes]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.
Date: November 25, 1982, 6:00 p.m.
Duration: 1 minute 53 seconds
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Item Type: Refine your search to only Video
Partner: UNT Libraries Special Collections
open access

Influence of ammonium availability on expression of nifD and amtB genes during biostimulation of a U(VI) contaminated aquifer: implications for U(VI) removal and monitoring the metabolic state of Geobacteraceae

Description: The influence of ammonium availability on bacterial community structure and the physiological status of Geobacter species during in situ bioremediation of uranium-contaminated groundwater was evaluated. Ammonium concentrations varied by 2 orders of magnitude (<4 to 400 ?M) across the study site. Analysis of 16S rRNA sequences suggested that ammonium may have been one factor influencing the community composition prior to acetate amendment with Rhodoferax species predominating over Geobacter s… more
Date: March 25, 2009
Creator: Mouser, Paula J.; N'Guessan, A. Lucie; Elifantz, Hila; Holmes, Dawn E.; Williams, Kenneth H; Wilkins, Michael J. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Fundamental Studies of Recombinant Hydrogenases

Description: This research addressed the long term goals of understanding the assembly and organization of hydrogenase enzymes, of reducing them in size and complexity, of determining structure/function relationships, including energy conservation via charge separation across membranes, and in screening for novel H2 catalysts. A key overall goal of the proposed research was to define and characterize minimal hydrogenases that are produced in high yields and are oxygen-resistant. Remarkably, in spite of deca… more
Date: January 25, 2014
Creator: Adams, Michael W
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Low Dose Gamma Irradiation Potentiates Secondary Exposure to Gamma Rays or Protons in Thyroid Tissue Analogs

Description: We have utilized our unique bioreactor model to produce three-dimensional thyroid tissue analogs that we believe better represent the effects of radiation in vivo than two-dimensional cultures. Our thyroid model has been characterized at multiple levels, including: cell-cell exchanges (bystander), signal transduction, functional changes and modulation of gene expression. We have significant preliminary data on structural, functional, signal transduction and gene expression responses from acute … more
Date: May 25, 2006
Creator: Green, Lora M
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Mitotic Exit Control as an Evolved Complex System

Description: The exit from mitosis is the last critical decision a cell has to make during a division cycle. A complex regulatory system has evolved to evaluate the success of mitotic events and control this decision. Whereas outstanding genetic work in yeast has led to rapid discovery of a large number of interacting genes involved in the control of mitotic exit, it has also become increasingly difficult to comprehend the logic and mechanistic features embedded in the complex molecular network. Our view is… more
Date: April 25, 2005
Creator: Bosl, W & Li, R
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Extracellular Matrix-Regulated Gene Expression RequiresCooperation of SWI/SNF and Transcription Factors

Description: Extracellular cues play crucial roles in the transcriptional regulation of tissue-specific genes, but whether and how these signals lead to chromatin remodeling is not understood and subject to debate. Using chromatin immunoprecipitation (ChIP) assays and mammary-specific genes as models, we show here that extracellular matrix (ECM) molecules and prolactin cooperate to induce histone acetylation and binding of transcription factors and the SWI/SNF complex to the {beta}- and ?-casein promoters. … more
Date: May 25, 2006
Creator: Xu, Ren; Spencer, Virginia A. & Bissell, Mina J.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

LiverTox: Advanced QSAR and Toxicogeomic Software for Hepatotoxicity Prediction

Description: YAHSGS LLC and Oak Ridge National Laboratory (ORNL) established a CRADA in an attempt to develop a predictive system using a pre-existing ORNL computational neural network and wavelets format. This was in the interest of addressing national needs for toxicity prediction system to help overcome the significant drain of resources (money and time) being directed toward developing chemical agents for commerce. The research project has been supported through an STTR mechanism and funded by the Natio… more
Date: February 25, 2011
Creator: Lu, Po-Yun & Yuracko, Katherine
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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