Lymphocytes from wasted mice express enhanced spontaneous and {gamma}-ray-induced apoptosis
Description:
Mice bearing the autosomal recessive mutation wasted (wst/wst) display a disease pattern including faulty repair of DNA damage in lymphocytes after radiation exposure, neurologic abnormalities, and immunodeficiency. Many of the features of this mouse model have suggested a premature or increased spontaneous frequency of apoptosis in thymocytes; past work has shown an inability to establish cultured T cell lines, an abnormally high death rate of stimulated T cells in culture, and an increased se…
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Date:
September 1, 1993
Creator:
Woloschak, Gayle E.; Chang-Liu, Chin-Mei; Chung, Jen & Libertin, Claudia R.
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Partner:
UNT Libraries Government Documents Department