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A Study of Hereditary Predisposition to Cardiovascular Diseases

Description: Because the many physicians and students of heredity have not been closely associated in finding that the causes of cardiovascular diseases might lie, in a large measure, to an inherited predisposition, this study has been undertaken; first, to contribute to several more case studies of cardiovascular diseases to the knowledge of heredity; second, to find if there is a possible successive occurrence of cardiovascular diseases in generation after generation; and third, to determine a possible mode of transmission from parents to offspring by an analysis of nine genealogies.
Date: 1949
Creator: McCarty, Juanita Mavis
Partner: UNT Libraries

Use of tree-based models to identify subgroups and increase power to detect linkage to cardiovascular disease traits

Description: This article discusses the use of tree-based models to identify subgroups and increase power to detect linkage to cardiovascular disease traits.
Date: December 31, 2003
Creator: Costello, Tracy Jennifer; Swartz, Michael D.; Sabripour, Mahyar; Gu, Xiangjun; Sharma, Rishika & Etzel, Carol J.
Partner: UNT College of Arts and Sciences

A common allele on chromosome 9 associated with coronary heartdisease

Description: Coronary heart disease (CHD) is a major cause of death in Western countries. Here we used genome-wide association scanning to identify a 58 kb interval on chromosome 9 that was consistently associated with CHD in six independent samples. The interval contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension or diabetes. Homozygotes for the risk allele comprise 20-25% of Caucasians and have a {approx}30-40% increased risk of CHD. These data indicate that the susceptibility allele acts through a novel mechanism to increase CHD risk in a large fraction of the population.
Date: March 1, 2007
Creator: McPherson, Ruth; Pertsemlidis, Alexander; Kavaslar, Nihan; Stewart, Alexandre; Roberts, Robert; Cox, David R. et al.
Partner: UNT Libraries Government Documents Department

Use of Rhenium-188 Liquid-Filled Balloons for Inhibition of Coronary Restenosis After PTCA - A New Opportunity for Nuclear Medicine

Description: Although the use of ionizing radiation for the treatment of benign lesions such as keloids has been available for nearly one hundred years, only recently have the cost effective benefits of such technology for the inhibition of arterial restenosis following controlled vessel damage from balloon angioplasty been fully realized. In particular, the use of balloons filled with solutions of beta-emitting radioisotopes for vessel irradiation provide the benefit of uniform vessel irradiation. Use of such contained ("unsealed") sources is expected to represent a new opportunity for nuclear medicine physicians working in conjunction with interventional cardiologists to provide this new approach for restenosis therapy.
Date: May 13, 1999
Creator: Knapp, F. F., Jr.; Spencer, R.H. & Stabin, M.
Partner: UNT Libraries Government Documents Department

Use of Reactor-Produced Radioisotopes for Prevention Restenosis After Angioplasty

Description: Coronary heart disease leads to myocardial infarction and is a major cause of death in the US. Myocardial infarctions result from atherosclerotic plaque deposits in the coronary arteries, reducing blood flow through these arteries which supply oxygen and nutrients to the heart muscle. The two major approaches for restoring adequate blood flow are coronary bypass graft surgery and coronary angioplasty. Angioplasty is a routinely used clinical procedure, where a deflated balloon attached to the end of a long catheter is inserted into an artery in the leg and then advanced through the aorta into the blocked regions of the coronary arteries. After positioning in the occluded region of the artery, the balloon is inflated with a pressurized saline solution which opens the artery restoring blood flow by pressing the atherosclerotic plaque into the vessel wall. Angioplasty is a widely performed procedure with the coronary arteries and is a much less expensive alternative to coronary bypass surgery. The best patients for angioplasty are those with single occlusions and this method is preferred over bypass grafting because of the significantly reduced expense. The reformation of plaque deposits in arteries (restenosis) following angioplasty, however, is a major clinical problem encountered in as high as 40 percent of patients. Because reduction of health care costs is a major national priority, development of effective new preventative methods for restenoses is an important national priority.
Date: December 21, 1999
Creator: Knapp, F.F. & Pipes, D.W.
Partner: UNT Libraries Government Documents Department

In Vivo Characterization of Human APOA5 Haplotypes

Description: Increased plasma triglycerides concentrations are an independent risk factor for cardiovascular disease. Numerous studies support a reproducible genetic association between two minor haplotypes in the human apolipoprotein A5 gene (APOA5) and increased plasma triglyceride concentrations. We thus sought to investigate the effect of these minor haplotypes (APOA5*2 and APOA5*3) on ApoAV plasma levels through the precise insertion of single-copy intact APOA5 haplotypes at a targeted location in the mouse genome. While we found no difference in the amount of human plasma ApoAV in mice containing the common APOA5*1 and minor APOA5*2 haplotype, the introduction of the single APOA5*3 defining allele (19W) resulted in 3-fold lower ApoAV plasma levels consistent with existing genetic association studies. These results indicate that S19W polymorphism is likely to be functional and explain the strong association of this variant with plasma triglycerides supporting the value of sensitive in vivo assays to define the functional nature of human haplotypes.
Date: October 1, 2006
Creator: Ahituv, Nadav; Akiyama, Jennifer; Chapman-Helleboid, Audrey; Fruchart, Jamila & Pennacchio, Len A.
Partner: UNT Libraries Government Documents Department

A human factors engineering approach to biomedical decision making: A new role for automatic target recognizer technologies

Description: This report identifies the key features noted as requirements in the diagnostic decision-making process of Single Photon Emission Computed Tomography (SPECT) cardiac imaging. The report discusses the critical issues that create the basic system framework for design of an automatic target recognizer (ATR) algorithm prototype to support diagnosis of coronary artery disease. Candidate feature discovery algorithms that may form the basis of future work include Adaptive Resonance Theory and Bayesian Decision Network. A framework for the practitioner-Human-System-Interface would include baseline patient history and demographic data; reference cardiac imagery history; and current overlay imagery to provide complementary information (i.e., coronary angiography, echocardiography, and SPECT images). The goal is to design a prototype that would represent a fused present and historical {open_quotes}whole{close_quotes} functional, structural, and physiologic cardiac patient model. This framework decision-assisting platform would be available to practitioner and student alike, with no {open_quotes}real-world{close_quotes} consequences.
Date: January 1, 1995
Creator: Sobel, A. L.; Stalker, K. T. & Yee, A.
Partner: UNT Libraries Government Documents Department

Intravenous coronary angiography utilizing K-emission and bremsstrahlung X-rays produced by electron bombardment

Description: The screening of the general population for coronary artery disease would be practical if a method existed for visualizing the extent of occlusion after an intravenous injection of contrast agent. Measurements performed with synchrotron radiation at SSRL and NSLS have shown that such an intravenous angiography procedure would be possible with an intense source of monochromatic X-rays. Because of the high cost of an electron synchrotron, theoretical analysis and experiments using inanimate phantoms has been undertaken to demonstrate the feasibility of using the spectrum produced by two appropriately chosen anode materials when bombarded with electrons in the 100--500 keV energy range for angiography. By using the X-rays emitted at 120{degree} to the incident electron direction, about 20--30% of the X-ray intensity would be due to K-emission lines. Calculations using the TIGERP Monte Carlo Code, have shown that high quality angiograms of human coronary arteries should be possible with a contrast agent containing ytterbium, if an electron beam pulses of 16 kJ were used for each anode target. The experimental program supported in part by the DOE has consisted of these theoretical calculations and experiments at the Dynamitron Electron Accelerator Facility at BNL.
Date: December 31, 1992
Partner: UNT Libraries Government Documents Department

Apolipoprotein AIF gene variant S347 is associated with increased risk of coronary heart disease and lower apolipoprotein AIV plasma concentrations

Description: The impact of common variants in the apolipoprotein gene cluster (APOC3-A4-A5) on prospective CHD risk was examined in healthy UK men. Of the 2808 men followed over nine years, 187 had a clinically defined CHD event. Examination of 9 single nucleotide polymorphisms (SNPs) in this group revealed that homozygotes for APOA4 S347 had significantly increased risk of CHD [Hazard ratio (HR) of 2.07 (95%CI 1.04-4.12)] while men homozygous for APOC3 1100T were protected (HR 0.28 (95%CI 0.09-0.87)). In stepwise multiple regression analysis, after entering all the variants and adjusting for established risk factors APOA4 T347S alone remained in the model. Using nine-SNP haplotype analysis, highest risk-estimate haplotypes carried APOA4 S347 and rare alleles of the two flanking intergenic markers. The protective effect of APOC31100T could be explained by negative linkage disequilibrium with these alleles. To determine the association of APOA4 T347S with apoAIVlevels, the relationship was examined in over 1600 healthy young European men and women. S347 homozygotes had significantly lower apoAIV plasma levels (13.48 + 0.6mg/dl) compared to carriers of the T347 allele (14.85 + 0.12 mg/dl) (p=0.025). These results demonstrate that genetic variation in and around APOA4, independent of effects of TG, is associated with risk of CHD and apoAIV levels, supporting an anti-atherogenic role for apoAIV.
Date: January 30, 2003
Creator: Wong, Wai-man R.; Hawe, Emma; Li, Lai K.; Miller, George J.; Nicaud, Viviane; Pennacchio, Len A. et al.
Partner: UNT Libraries Government Documents Department

Ernest Orlando Berkeley National Laboratory - Fundamental and applied research on lean premixed combustion

Description: Ernest Orland Lawrence Berkeley National Laboratory (Berkeley Lab) is the oldest of America's national laboratories and has been a leader in science and engineering technology for more than 65 years, serving as a powerful resource to meet Us national needs. As a multi-program Department of Energy laboratory, Berkeley Lab is dedicated to performing leading edge research in the biological, physical, materials, chemical, energy, environmental and computing sciences. Ernest Orlando Lawrence, the Lab's founder and the first of its nine Nobel prize winners, invented the cyclotron, which led to a Golden Age of particle physics and revolutionary discoveries about the nature of the universe. To this day, the Lab remains a world center for accelerator and detector innovation and design. The Lab is the birthplace of nuclear medicine and the cradle of invention for medical imaging. In the field of heart disease, Lab researchers were the first to isolate lipoproteins and the first to determine that the ratio of high density to low density lipoproteins is a strong indicator of heart disease risk. The demise of the dinosaurs--the revelation that they had been killed off by a massive comet or asteroid that had slammed into the Earth--was a theory developed here. The invention of the chemical laser, the unlocking of the secrets of photosynthesis--this is a short preview of the legacy of this Laboratory.
Date: July 7, 1999
Creator: Cheng, Robert K.
Partner: UNT Libraries Government Documents Department

Lipoprotein subclasses in genetic studies: The Berkeley Data Set

Description: Data from the Berkeley Data Set was used to investigate familial correlations of HDL-subclasses. Analysis of the sibling intraclass correlation coefficient by HDL particle diameter showed that sibling HDL levels were significantly correlated for HDL{sub 2b}, HDL{sub 3a} and HDL{sub 3b} subclasses. The percentage of the offsprings` variance explained by their two parents. Our finding that parents and offspring-have the highest correlation for HDL{sub 2b} is consistent with published reports that show higher heritability estimates for HDL{sub 2} compared with HDL{sub 3}{minus} cholesterol.
Date: October 1, 1992
Creator: Krauss, R. M.; Williams, P. T.; Blanche, P. J.; Cavanaugh, A.; Holl, L. G. & Austin, M. A.
Partner: UNT Libraries Government Documents Department


Description: There is overwhelming evidence that addiction is a disease of the brain (Leshner, 1997). Yet public perception that addiction is a reflection of moral weakness or a lack of willpower persists. The insidious consequence of this perception is that we lose sight of the fact that there are enormous medical consequences of addiction including the fact that a large fraction of the total deaths from cancer and heart disease are caused by smoking addiction. Ironically the medical school that educates physicians in addiction medicine and the cancer hospital that has a smoking cessation clinic are vanishingly rare and efforts at harm reduction are frequently met with a public indignation. Meanwhile the number of people addicted to substances is enormous and increasing particularly the addictions to cigarettes and alcohol. It is particularly tragic that addiction usually begins in adolescence and becomes a chronic relapsing problem and there are basically no completely effective treatments. Clearly we need to understand how drugs of abuse affect the brain and we need to be creative in using this information to develop effective treatments. Imaging technologies have played a major role in the conceptualization of addiction as a disease of the brain (Fowler et al., 1998a; Fowler et al., 1999a). New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology and medicine. This topic cuts across the medical specialties of neurology, psychiatry, cancer and heart disease because of the high medical, social and economic toll that drugs of abuse, including and especially the legal drugs, cigarettes and alcohol, take on society. In this chapter we will begin by highlighting the important role that chemistry has played in making it possible to quantitatively image the movement ...
Date: January 29, 2001
Creator: Fowler, J. S.; Volkow, N. D.; Ding, Y. S.; Logan, J. & Wang, G. J.
Partner: UNT Libraries Government Documents Department

Ethical and legal issues arising from complex genetic disorders. DOE final report

Description: The project analyzed the challenges raised by complex genetic disorders in genetic counselling, for clinical practice, for public health, for quality assurance, and for protection against discrimination. The research found that, in some settings, solutions created in the context of single gene disorders are more difficult to apply to complex disorders. In other settings, the single gene solutions actually backfired and created additional problems when applied to complex genetic disorders. The literature of five common, complex genetic disorders--Alzheimer's, asthma, coronary heart disease, diabetes, and psychiatric illnesses--was evaluated in depth.
Date: October 9, 2002
Creator: Andrews, Lori
Partner: UNT Libraries Government Documents Department

Dynamics of Adipocyte Turnover in Humans

Description: Obesity is increasing in an epidemic fashion in most countries and constitutes a public health problem by enhancing the risk for cardiovascular disease and metabolic disorders such as type 2 diabetes. Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time in recent history. The factors determining fat mass in adult humans are not fully understood, but increased lipid storage in already developed fat cells is thought to be most important. We show that adipocyte number is a major determinant for the fat mass in adults. However, the number of fat cells stays constant in adulthood in lean and obese and even under extreme conditions, indicating that the number of adipocytes is set during childhood and adolescence. To establish the dynamics within the stable population of adipocytes in adults, we have measured adipocyte turnover by analyzing the integration of {sup 14}C derived from nuclear bomb tests in genomic DNA. Approximately 10% of fat cells are renewed annually at all adult ages and levels of body mass index. Neither adipocyte death nor generation rate is altered in obesity, suggesting a tight regulation of fat cell number that is independent of metabolic profile in adulthood. The high turnover of adipocytes establishes a new therapeutic target for pharmacological intervention in obesity.
Date: July 16, 2007
Creator: Spalding, K; Arner, E; Westermark, P; Bernard, S; Buchholz, B; Bergmann, O et al.
Partner: UNT Libraries Government Documents Department


Description: Environmental mercury continues to be of concern to public health advocates, both in the U.S. and abroad, and new research continues to be published. A recent analysis of potential health benefits of reduced mercury emissions has opened a new area of public health concern: adverse effects on the cardiovascular system, which could account for the bulk of the potential economic benefits. The authors were careful to include caveats about the uncertainties of such impacts, but they cited only a fraction of the applicable health effects literature. That literature includes studies of the potentially harmful ingredient (methylmercury, MeHg) in fish, as well as of a beneficial ingredient, omega-3 fatty acids or ''fish oils''. The U.S. Food and Drug Administration (FDA) recently certified that some of these fat compounds that are primarily found in fish ''may be beneficial in reducing coronary heart disease''. This paper briefly summarizes and categorizes the extensive literature on both adverse and beneficial links between fish consumption and cardiovascular health, which are typically based on studies of selected groups of individuals (cohorts). Such studies tend to comprise the ''gold standard'' of epidemiology, but cohorts tend to exhibit a great deal of variability, in part because of the limited numbers of individuals involved and in part because of interactions with other dietary and lifestyle considerations. Note that eating fish will involve exposure to both the beneficial effects of fatty acids and the potentially harmful effects of contaminants like Hg or PCBs, all of which depend on the type of fish but tend to be correlated within a population. As a group, the cohort studies show that eating fish tends to reduce mortality, especially due to heart disease, for consumption rates up to about twice weekly, above which the benefits tend to level off. A Finnish cohort study showed increased ...
Date: September 21, 2005
Partner: UNT Libraries Government Documents Department

BEST: Bilingual environmental science training: Grades 5--6

Description: This booklet is one of a series of bilingual guides to environmental-science learning activities for students to do at home. Lesson objectives, materials required, procedure, vocabulary, and subjects integrated into the lesson are described in English. A bilingual glossary, alphabetized by English entries, with Spanish equivalents and definitions in both English and Spanish, follows the lesson descriptions, and is itself followed by a bibliography of English-language references. This booklet includes descriptions of ten lessons that cover the following topics: safe and unsafe conditions for chemical combinations; growth rates and environmental needs of plants; photosynthesis and effects of ozone-layer depletion; the circulatory system, the importance of exercise to the heart, and selected circulatory diseases; the nervous system; specific nutritional values of the different food groups; significance of including, reducing, or eliminating certain foods for a healthy diet; effects of some common chemicals on plant growth and animal life; plants` and animals` natural habitats; and dangers of non-biodegradable garbage.
Date: March 1, 1996
Partner: UNT Libraries Government Documents Department

Experimental validation of superconducting quantum interference device sensors for electromagnetic scattering in geologic structures

Description: This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). This project has supported the collaborative development with Sandia National Laboratories (SNL) and the University of New Mexico (UNM) of two critical components for a hand-held low-field magnetic sensor based on superconducting quantum interference device (SQUID) sensor technology. The two components are a digital signal processing (DSP) algorithm for background noise rejection and a small hand-held dewar cooled by a cryocooler. A hand-held sensor has been designed and fabricated for detection of extremely weak magnetic fields in unshielded environments. The sensor is capable of measuring weak magnetic fields in unshielded environments and has multiple applications. We have chosen to pursue battlefield medicine as the highest probability near-term application because of stated needs of several agencies.
Date: October 1, 1997
Creator: Krauss, R.H. Jr.; Flynn, E. & Ruminer, P.
Partner: UNT Libraries Government Documents Department

Heart pathology determination from electrocardiogram signals by application of deterministic chaos mathematics. CRADA final report

Description: It is well known that the electrical signals generated by the heart exhibit nonlinear, chaotic dynamics. A number of heart pathologies alter heartbeat dynamics and/or the electrical properties of the heart, which, in turn, alter electrocardiogram signals. Electrocardiogram techniques in common use for diagnosing pathologies have limited sensitivity and specificity. This leads to a relatively high misdiagnosis rate for ventricular fibrillation. It is also known that the linear analysis tools utilized (such as fast Fourier transforms and linear statistics) are limited in their ability to find subtle changes or characteristic signatures in nonlinear chaotic electrocardiogram signals. In contrast, the authors` research indicates that chaotic time-series analysis tools that they have developed allow quantification of the nonlinear nature of dynamic systems in the form of nonlinear statistics, and also enable characteristic signatures to be identified. The goal of this project is to modify these tools to increase and enhance the medically useful information obtained from electrocardiogram signals through the application of chaotic time series analysis tools. In the one year of the project, the tools have been extended to enhance the capabilities for detecting ventricular fibrillation. Chaotic time-series analysis provides a means to increase sensitivity in detecting general heart dynamics. Oak Ridge National Laboratory specialists have worked with Physio-Control and their medical collaborators to extend the capabilities of state-of-the-art electrocardiogram systems and interpretation of results.
Date: March 1, 1999
Creator: Clapp, N.E.; Hively, L.M. & Stickney, R.E.
Partner: UNT Libraries Government Documents Department

Diagnostic and therapeutic applications of diode lasers and solid state lasers in medicine

Description: The Texas Medical Center in Houston and the nearby UT Medical Branch at Galveston together constitute a major center of medical research activities. Laser applications in medicine are under development with the engineering assistance of the colloborating engineering centers at Rice University, UT-Austin, and Texas A M Univ. In addition, this collective is collaborating with the Naval Research Laboratory, where new developments in laser design are underway, in order to transfer promising new laser technology rapidly into the medical environment.
Date: May 1, 1992
Creator: Jacques, S.L. (Texas Univ., Houston, TX (United States). Cancer Center); Welch, A.J. (Texas Univ., Austin, TX (United States)); Motamedi, M. (Texas Univ., Galveston, TX (United States). Medical Branch); Rastegar, S. (Texas A and M Univ., College Station, TX (United States)); Tittel, F. (Rice Univ., Houston, TX (United States)) & Esterowitz, L. (Naval Research Lab., Washington, DC (United States))
Partner: UNT Libraries Government Documents Department

New Compton densitometer for measuring pulmonary edema

Description: Pulmonary edema is the pathological increase of extravascular lung water found most often in patients with congestive heart failure and other critically ill patients who suffer from intravenous fluid overload. A non-invasive lung density monitor that is accurate, easily portable, safe and inexpensive is needed for clinical evaluation of pulmonary edema. Other researchers who have employed Compton scattering techniques generally used systems of extended size and detectors with poor energy resolution. This has resulted in significant systematic biases from multiply-scattered photons and larger errors in counting statistics at a given radiation dose to the patient. We are proposing a patented approach in which only backscattered photons are measured with a high-resolution HPGe detector in a compact system geometry. By proper design and a unique data extraction scheme, effects of the variable chest wall on lung density measurements are minimized. Preliminary test results indicate that with a radioactive source of under 30 GBq, it should be possible to make an accurate lung density measurement in one minute, with a risk of radiation exposure to the patient a thousand times smaller than that from a typical chest x-ray. The ability to make safe, frequent lung density measurements could be very helpful for monitoring the course of P.E. at the hospital bedside or outpatient clinics, and for evaluating the efficacy of therapy in clinical research. 6 refs., 5 figs.
Date: October 1, 1985
Creator: Loo, B.W.; Goulding, F.S. & Simon, D.S.
Partner: UNT Libraries Government Documents Department

Research on human genetics in Iceland. Progress report

Description: Records of the Icelandic Population are being used to investigate the possible inheritance of disabilities and diseases as well as other characters and the effect of environment on man. The progress report of research covers the period 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized and linked together to make them effective for use in hereditary studies.
Date: October 31, 1980
Partner: UNT Libraries Government Documents Department

Progress report on research on human genetics in Iceland

Description: Records of the Icelandic population are being used to investigate the possible inheritance of disabilities and diseases as well as other characteristics and the effect of environment on man. The progress report of research covers the period from 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized and linked together to make them effective for use in hereditary studies.
Date: October 31, 1980
Partner: UNT Libraries Government Documents Department

[News Clip: Hypertension #3]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story. This story aired at 5:00 P.M.
Date: May 10, 1978
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections