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Summary and results of the joint WMD-DAC/Alameda County bioterrorism response plan exercise.

Description: On June 12,2003, the Alameda County Public Health Department and Sandia National Laboratories/CA jointly conducted an exercise that used a Weapons of Mass Destruction-Decision Analysis Center (WMD-DAC) bioterrorism attack simulation to test the effectiveness of the county's emergency response plan. The exercise was driven by an assumed release (in the vicinity of the Berkeley Marina), and subsequent spread, of a small quantity of aerosolized, weapons-grade anthrax spores. The simulation used several key WMD-DAC capabilities, namely: (1) integration with an atmospheric dispersion model to calculate expected dose levels in the affected areas, (2) a individual-tracking capability for both infected and non-infected persons as they made decisions, sought treatment, and received prophylaxis drugs, and (3) a user interface that allows exercise participants to affect the scenario evolution and outcome. The analysis of the county's response plan included documenting and reviewing the decisions made by participants during the exercise. Twenty-six local and regional officials representing the health care system, emergency medical services and law enforcement were involved in responding to the simulated attack. The results of this joint effort include lessons learned both by the Alameda County officials regarding implementation of their bioterrorism response plan and by the Sandia representatives about conducting exercises of this type. These observations are reviewed in this report, and they form a basis for providing a better understanding of group/individual decision processes and for identifying effective communication options among decision makers.
Date: November 1, 2003
Creator: Manley, Dawn Kataoka; Lipkin, Joel; West, Todd H.; Tam, Ricky; Hirano, Howard H. & Ammerlahn, Heidi R.
Partner: UNT Libraries Government Documents Department

Summary Document: Restoration Plan for Major Airports after a Bioterrorist Attack

Description: This document provides general guidelines for developing a Restoration Plan for a major airport following release of a biological warfare agent. San Francisco International Airport was selected as the example airport during development of the Plan to illustrate specific details. The spore forming bacterium Bacillus anthracis was selected as the biological agent of primary concern because it is the most difficult of known bioterrorism agents to inactivate and is considered to be one of the agents most likely to be used as a biological weapon. The focus of the Plan is on activities associated with the Characterization, Remediation, and Clearance Phases that are defined herein. Activities associated with the Notification and First-Response Phases are briefly discussed in Appendixes A and B, respectively. In addition to the main text of this Plan and associated appendixes, a data supplement was developed specifically for San Francisco International Airport. Requests for the data supplement must be made directly to the Emergency Planning Operations Division of San Francisco International Airport.
Date: January 11, 2007
Creator: Raber, E
Partner: UNT Libraries Government Documents Department

The Nature of the Bioterrorism Threat

Description: This analysis provides an overview of the nature of the bioterrorism threat. It identifies potential CDC Class A biological agents that are likely candidates for use in a terrorist incident and describes the known sources of vulnerability. The paper also summarizes S&T resources/needs and assesses response options for achieving effective biodefense against terrorist threats.
Date: February 25, 2003
Creator: Regens, J. L.
Partner: UNT Libraries Government Documents Department

Applied and Environmental Microbiology [agenda and attendee list]

Description: Conference sessions were held on the following topics: Microbes, metals and metabolism; Biological weapons, facts and fiction; Antimicrobials in food safety and human health; Microbial DNA chips; Global processes, microorganisms and molecular ecology; Microbes, art and artifacts; Functional genomics of environmental strains; and Biodegradation and biotransformation breakthroughs. There was also a special lecture titled ''The hand is quicker than a sneeze as a disseminator of disease.''
Date: July 3, 1999
Partner: UNT Libraries Government Documents Department

An environmental sampling model for combining judgment and randomly placed samples

Description: In the event of the release of a lethal agent (such as anthrax) inside a building, law enforcement and public health responders take samples to identify and characterize the contamination. Sample locations may be rapidly chosen based on available incident details and professional judgment. To achieve greater confidence of whether or not a room or zone was contaminated, or to certify that detectable contamination is not present after decontamination, we consider a Bayesian model for combining the information gained from both judgment and randomly placed samples. We investigate the sensitivity of the model to the parameter inputs and make recommendations for its practical use.
Date: August 23, 2007
Creator: Sego, Landon H.; Anderson, Kevin K.; Matzke, Brett D.; Sieber, Karl; Shulman, Stanley; Bennett, James et al.
Partner: UNT Libraries Government Documents Department

Modeling Dispersion of Chemical-Biological Agents in Three Dimensional Living Space

Description: This report documents a series of calculations designed to demonstrate Sandia's capability in modeling the dispersal of chemical and biological agents in complex three-dimensional spaces. The transport of particles representing biological agents is modeled in a single room and in several connected rooms. The influence of particle size, particle weight and injection method are studied.
Date: February 1, 2002
Creator: Winters, William S.
Partner: UNT Libraries Government Documents Department

Quick-look eye-safety assessment for the short range lidar

Description: This is a quick-look eye-safety assessment for the Short Range (SR) lidar, a system under development for standoff biological aerosol detection in the outdoor environment. The ground-vehicle-mounted SR lidar system will scan a sector of the nearby atmosphere with a repetitively pulsed, multiple-wavelength, UV/IR laser beam. This laser is not intrinsically eye-safe, and hence the SR lidar system requires a protection system to minimize the risk of eye exposures above the ANSI-standard maximum permissible exposure within a nominal hazard zone. The nominal ocular hazard distance for the UV/IR laser itself was calculated to be 6 km. The protection system, which will include a scan-stop detector and a laser beam path interrogator, currently is conceptual only. Until the complete protection system is designed, evaluated, and tested, and a more detailed safety assessment has been performed, the eye-safety issue for the SR lidar system cannot be resolved.
Date: July 2, 1998
Creator: Wehner, T.R.
Partner: UNT Libraries Government Documents Department

Rapid, potentially automatable, method extract biomarkers for HPLC/ESI/MS/MS to detect and identify BW agents

Description: The program proposes to concentrate on the rapid recovery of signature biomarkers based on automated high-pressure, high-temperature solvent extraction (ASE) and/or supercritical fluid extraction (SFE) to produce lipids, nucleic acids and proteins sequentially concentrated and purified in minutes with yields especially from microeukaryotes, Gram-positive bacteria and spores. Lipids are extracted in higher proportions greater than classical one-phase, room temperature solvent extraction without major changes in lipid composition. High performance liquid chromatography (HPLC) with or without derivatization, electrospray ionization (ESI) and highly specific detection by mass spectrometry (MS) particularly with (MS){sup n} provides the detection, identification and because the signature lipid biomarkers are both phenotypic as well as genotypic biomarkers, insights into potential infectivity of BW agents. Feasibility has been demonstrated with detection, identification, and determination of infectious potential of Cryptosporidium parvum at the sensitivity of a single oocyst (which is unculturable in vitro) and accurate identification and prediction, pathogenicity, and drug-resistance of Mycobacteria spp.
Date: December 1997
Creator: White, D. C.; Burkhalter, R. S.; Smith, C. & Whitaker, K. W.
Partner: UNT Libraries Government Documents Department

Miniature Sensors for Biological Warfare Agents using Fatty Acid Profiles: LDRD 10775 Final Report

Description: Rapid detection and identification of bacteria and other pathogens is important for many civilian and military applications. The taxonomic significance, or the ability to differentiate one microorganism from another, using fatty acid content and distribution is well known. For analysis fatty acids are usually converted to fatty acid methyl esters (FAMEs). Bench-top methods are commercially available and recent publications have demonstrated that FAMEs can be obtained from whole bacterial cells in an in situ single-step pyrolysis/methylation analysis. This report documents the progress made during a three year Laboratory Directed Research and Development (LDRD) program funded to investigate the use of microfabricated components (developed for other sensing applications) for the rapid identification of bioorganisms based upon pyrolysis and FAME analysis. Components investigated include a micropyrolyzer, a microGC, and a surface acoustic wave (SAW) array detector. Results demonstrate that the micropyrolyzer can pyrolyze whole cell bacteria samples using only milliwatts of power to produce FAMEs from bacterial samples. The microGC is shown to separate FAMEs of biological interest, and the SAW array is shown to detect volatile FAMEs. Results for each component and their capabilities and limitations are presented and discussed. This project has produced the first published work showing successful pyrolysis/methylation of fatty acids and related analytes using a microfabricated pyrolysis device.
Date: January 1, 2003
Partner: UNT Libraries Government Documents Department

Information Technology and Community Restoration Studies/Task 1: Information Technology

Description: Executive Summary The Interagency Biological Restoration Demonstration—a program jointly funded by the Department of Defense's Defense Threat Reduction Agency and the Department of Homeland Security's (DHS's) Science and Technology Directorate—is developing policies, methods, plans, and applied technologies to restore large urban areas, critical infrastructures, and Department of Defense installations following the intentional release of a biological agent (anthrax) by terrorists. There is a perception that there should be a common system that can share information both vertically and horizontally amongst participating organizations as well as support analyses. A key question is: "How far away from this are we?" As part of this program, Pacific Northwest National Laboratory conducted research to identify the current information technology tools that would be used by organizations in the greater Seattle urban area in such a scenario, to define criteria for use in evaluating information technology tools, and to identify current gaps. Researchers interviewed 28 individuals representing 25 agencies in civilian and military organizations to identify the tools they currently use to capture data needed to support operations and decision making. The organizations can be grouped into five broad categories: defense (Department of Defense), environmental/ecological (Environmental Protection Agency/Ecology), public health and medical services, emergency management, and critical infrastructure. The types of information that would be communicated in a biological terrorism incident include critical infrastructure and resource status, safety and protection information, laboratory test results, and general emergency information. The most commonly used tools are WebEOC (web-enabled crisis information management systems with real-time information sharing), mass notification software, resource tracking software, and NW WARN (web-based information to protect critical infrastructure systems). It appears that the current information management tools are used primarily for information gathering and sharing—not decision making. Respondents identified the following criteria for a future software system. It is easy to learn, updates information ...
Date: November 19, 2009
Creator: Upton, Jaki F.; Lesperance, Ann M. & Stein, Steven L.
Partner: UNT Libraries Government Documents Department

Airborne Particulate Threat Assessment

Description: Aerosol threat detection requires the ability to discern between threat agents and ambient background particulate matter (PM) encountered in the environment. To date, Raman imaging technology has been demonstrated as an effective strategy for the assessment of threat agents in the presence of specific, complex backgrounds. Expanding our understanding of the composition of ambient particulate matter background will improve the overall performance of Raman Chemical Imaging (RCI) detection strategies for the autonomous detection of airborne chemical and biological hazards. Improving RCI detection performance is strategic due to its potential to become a widely exploited detection approach by several U.S. government agencies. To improve the understanding of the ambient PM background with subsequent improvement in Raman threat detection capability, ChemImage undertook the Airborne Particulate Threat Assessment (APTA) Project in 2005-2008 through a collaborative effort with the National Energy Technology Laboratory (NETL), under cooperative agreement number DE-FC26-05NT42594. During Phase 1 of the program, a novel PM classification based on molecular composition was developed based on a comprehensive review of the scientific literature. In addition, testing protocols were developed for ambient PM characterization. A signature database was developed based on a variety of microanalytical techniques, including scanning electron microscopy, FT-IR microspectroscopy, optical microscopy, fluorescence and Raman chemical imaging techniques. An automated particle integrated collector and detector (APICD) prototype was developed for automated collection, deposition and detection of biothreat agents in background PM. During Phase 2 of the program, ChemImage continued to refine the understanding of ambient background composition. Additionally, ChemImage enhanced the APICD to provide improved autonomy, sensitivity and specificity. Deliverables included a Final Report detailing our findings and APICD Gen II subsystems for automated collection, deposition and detection of ambient particulate matter. Key findings from the APTA Program include: Ambient biological PM taxonomy; Demonstration of key subsystems needed for autonomous bioaerosol detection; ...
Date: December 31, 2008
Creator: Treado, Patrick; Klueva, Oksana & Beckstead, Jeffrey
Partner: UNT Libraries Government Documents Department

International biosecurity symposium : securing high consequence pathogens and toxins : symposium summary.

Description: The National Nuclear Security Administration (NNSA) Office of Nonproliferation Policy sponsored an international biosecurity symposium at Sandia National Laboratories (SNL). The event, entitled 'Securing High Consequence Pathogens and Toxins', took place from February 1 to February 6, 2004 and was hosted by Dr. Reynolds M. Salerno, Principal Member of the Technical Staff and Program Manager of the Biosecurity program at Sandia. Over 60 bioscience and policy experts from 14 countries gathered to discuss biosecurity, a strategy aimed at preventing the theft and sabotage of dangerous pathogens and toxins from bioscience facilities. Presentations delivered during the symposium were interspersed with targeted discussions that elucidated, among other things, the need for subsequent regional workshops on biosecurity, and a desire for additional work toward developing international biosecurity guidelines.
Date: June 1, 2004
Partner: UNT Libraries Government Documents Department

Catastrophic Incident Recovery: Long-Term Recovery from an Anthrax Event Symposium

Description: On March 19, 2008, policy makers, emergency managers, and medical and Public Health officials convened in Seattle, Washington, for a workshop on Catastrophic Incident Recovery: Long-Term Recovery from an Anthrax Event. The day-long symposium was aimed at generating a dialogue about restoration and recovery through a discussion of the associated challenges that impact entire communities, including people, infrastructure, and critical systems.
Date: June 30, 2008
Creator: Lesperance, Ann M.
Partner: UNT Libraries Government Documents Department

Bioforensics: Characterization of biological weapons agents by NanoSIMS

Description: The anthrax attacks of Fall 2001 highlight the need to develop forensic methods based on multiple identifiers to determine the origin of biological weapons agents. Genetic typing methods (i.e., DNA and RNA-based) provide one attribution technology, but genetic information alone is not usually sufficient to determine the provenance of the material. Non-genetic identifiers, including elemental and isotopic signatures, provide complementary information that can be used to identify the means, geographic location and date of production. Under LDRD funding, we have successfully developed the techniques necessary to perform bioforensic characterization with the NanoSIMS at the individual spore level. We have developed methods for elemental and isotopic characterization at the single spore scale. We have developed methods for analyzing spore sections to map elemental abundance within spores. We have developed rapid focused ion beam (FIB) sectioning techniques for spores to preserve elemental and structural integrity. And we have developed a high-resolution depth profiling method to characterize the elemental distribution in individual spores without sectioning. We used these newly developed methods to study the controls on elemental abundances in spores, characterize the elemental distribution of in spores, and to study elemental uptake by spores. Our work under this LDRD project attracted FBI and DHS funding for applied purposes.
Date: February 26, 2007
Creator: Weber, P K; Ghosal, S; Leighton, T J; Wheeler, K E & Hutcheon, I D
Partner: UNT Libraries Government Documents Department

Biosecurity reference : CFR-listed agent and toxin summaries.

Description: This reference document provides summary information on the animal, plant, zoonotic, and human pathogens and toxins regulated and categorized by 9 CFR 331 and 7 CFR 121, 'Agricultural Bioterrorism Protection Act of 2002; Possession, Use and Transfer of Biological Agents and Toxins,' and 42 CFR 73, 'Possession, Use, and Transfer of Select Agents and Toxins.' Summary information includes, at a minimum, a description of the agent and its associated symptoms; often additional information is provided on the diagnosis, treatment, geographic distribution, transmission, control and eradication, and impacts on public health.
Date: September 1, 2003
Creator: Barnett, Natalie Beth
Partner: UNT Libraries Government Documents Department

Draft Guidance: Response, Restoration, and Recovery Checklist for Biologically Contaminated Facilities

Description: The Checklist for Facility Response, Restoration, and Recovery presented in this document is principally focused on the Consequence Management Phase of a biothreat agent (i.e., Bacillus anthracis) release at a large facility, such as an airport or subway. Information in this document conforms to the National Response Plan (NRP) (DHS 2004) and the National Incident Management System (NIMS 2004). Under these two guidance documents, the personnel responsible for managing biological response and recovery efforts--that is, the decision-makers--are members of an Incident Command (IC), which is likely to transition to a Unified Command (UC) in the event of a biological warfare agent attack. A UC is used when more than one agency has incident jurisdiction or when incidents cross political jurisdictions. The location for primary, tactical-level command and management is referred to as the Incident Command Post (ICP), as described in the NRP. Thus, regardless of whether an IC or an UC is used, the responsible entities are located at an ICP. Agencies work together through designated members of the UC to establish their designated Incident Commanders at a single ICP and to establish a common set of objectives and strategies and a single Incident Action Plan. Initially during the Crisis Management Phase, the Incident Commander is likely to be the Chief of the fire department that serves the affected facility. As life-safety issues are resolved and the Crisis Management Phase shifts to the Consequence Management Phase, the work of characterization, decontamination, and facility clearance begins. There will likely be a coincident transition in organizational structure as well, and new restoration-focused groups, units, and personnel will be added as restoration needs are anticipated. Depending on the specific facility and type of incident, the responsible individual (Incident Commander or Unified Commander) within the UC during the Consequence Management Phase could be the ...
Date: August 15, 2006
Creator: Mancieri, S; Raber, E; Carlsen, T; Fish, C; MacQueen, D; Hoppes, W et al.
Partner: UNT Libraries Government Documents Department

International perspectives on mitigating laboratory biorisks.

Description: The International Perspectives on Mitigating Laboratory Biorisks workshop, held at the Renaissance Polat Istanbul Hotel in Istanbul, Republic of Turkey, from October 25 to 27, 2010, sought to promote discussion between experts and stakeholders from around the world on issues related to the management of biological risk in laboratories. The event was organized by Sandia National Laboratories International Biological Threat Reduction program, on behalf of the US Department of State Biosecurity Engagement Program and the US Department of Defense Cooperative Biological Engagement Program. The workshop came about as a response to US Under Secretary of State Ellen O. Tauscher's statements in Geneva on December 9, 2009, during the Annual Meeting of the States Parties to the Biological Weapons Convention (BWC). Pursuant to those remarks, the workshop was intended to provide a forum for interested countries to share information on biorisk management training, standards, and needs. Over the course of the meeting's three days, participants discussed diverse topics such as the role of risk assessment in laboratory biorisk management, strategies for mitigating risk, measurement of performance and upkeep, international standards, training and building workforce competence, and the important role of government and regulation. The meeting concluded with affirmations of the utility of international cooperation in this sphere and recognition of positive prospects for the future. The workshop was organized as a series of short presentations by international experts on the field of biorisk management, followed by breakout sessions in which participants were divided into four groups and urged to discuss a particular topic with the aid of a facilitator and a set of guiding questions. Rapporteurs were present during the plenary session as well as breakout sessions and in particular were tasked with taking notes during discussions and reporting back to the assembled participants a brief summary of points discussed. The ...
Date: November 1, 2010
Creator: Pinard, William J. & Salazar, Carlos A.
Partner: UNT Libraries Government Documents Department

Validation of Statistical Sampling Algorithms in Visual Sample Plan (VSP): Summary Report

Description: The U.S. Department of Homeland Security, Office of Technology Development (OTD) contracted with a set of U.S. Department of Energy national laboratories, including the Pacific Northwest National Laboratory (PNNL), to write a Remediation Guidance for Major Airports After a Chemical Attack. The report identifies key activities and issues that should be considered by a typical major airport following an incident involving release of a toxic chemical agent. Four experimental tasks were identified that would require further research in order to supplement the Remediation Guidance. One of the tasks, Task 4, OTD Chemical Remediation Statistical Sampling Design Validation, dealt with statistical sampling algorithm validation. This report documents the results of the sampling design validation conducted for Task 4. In 2005, the Government Accountability Office (GAO) performed a review of the past U.S. responses to Anthrax terrorist cases. Part of the motivation for this PNNL report was a major GAO finding that there was a lack of validated sampling strategies in the U.S. response to Anthrax cases. The report (GAO 2005) recommended that probability-based methods be used for sampling design in order to address confidence in the results, particularly when all sample results showed no remaining contamination. The GAO also expressed a desire that the methods be validated, which is the main purpose of this PNNL report. The objective of this study was to validate probability-based statistical sampling designs and the algorithms pertinent to within-building sampling that allow the user to prescribe or evaluate confidence levels of conclusions based on data collected as guided by the statistical sampling designs. Specifically, the designs found in the Visual Sample Plan (VSP) software were evaluated. VSP was used to calculate the number of samples and the sample location for a variety of sampling plans applied to an actual release site. Most of the sampling designs ...
Date: February 18, 2009
Creator: Nuffer, Lisa L; Sego, Landon H.; Wilson, John E.; Hassig, Nancy L.; Pulsipher, Brent A. & Matzke, Brett D.
Partner: UNT Libraries Government Documents Department

Bioaerosol collection and concentration for microseparations-based detectors.

Description: The ability to detect Weapons of Mass Destruction biological agents rapidly and sensitively is vital to homeland security, spurring development of compact detection systems at Sandia and elsewhere. One such system is Sandia's microseparations-based pChemLab. Many bio-agents are serious health threats even at extremely low concentrations. Therefore, a universal challenge for detection systems is the efficient collection and selective transport of highly diffuse bio-agents against the enormous background of benign particles and species ever present in the ambient environment. We have investigated development of a ''front end'' system for the collection, preconcentration, and selective transport of aerosolized biological agents from dilute (1-10 active particles per liter of air) atmospheric samples, to ultimate concentrations of {approx}20 active particles per microliter of liquid, for interface with microfluidic-based analyses and detection systems. Our approach employs a Sandia-developed aerosol particle-focusing microseparator array to focus size-selected particles into a mating microimpinger array of open microfluidic transport channels. Upon collection (i.e., impingement, submergence, and liquid suspension), microfluidic dielectrophoretic particle concentrators and sorters can be employed to further concentrate and selectively transport bio-agent particles to the sample preparation stages of microfluidic analyses and detection systems. This report documents results in experimental testing, modeling and analysis, component design, and materials fabrication critical to establishing proof-of-principle for this collection ''front end''. Outstanding results have been achieved for the aerodynamic microseparator, and for the post-collection dielectrophoretic concentrator and sorter. Results have been obtained for the microimpinger, too, but issues of particle-trapping by surface tension in liquid surfaces have proven difficult. Subsequent particle submergence into liquid suspension for microfluidic transport has been demonstrated only inefficiently despite significant and varied effort. Importantly, the separate technologies whose development is described, (inertial microseparator, dielectrophoretic corduroy concentrator/sorter) should each, independently, prove greatly useful in a variety of additional applications.
Date: March 1, 2005
Creator: Cummings, Eric B. (Sandia National Laboratories, Livermore, CA); Ellis, C. R. Bowe (Sandia National Laboratories, Livermore, CA); Kanouff, Michael P. (Sandia National Laboratories, Livermore, CA); Rader, Daniel John & Wally, Karl (Sandia National Laboratories, Livermore, CA)
Partner: UNT Libraries Government Documents Department

Bioagent detection using miniaturized NMR and nanoparticle amplification : final LDRD report.

Description: This LDRD program was directed towards the development of a portable micro-nuclear magnetic resonance ({micro}-NMR) spectrometer for the detection of bioagents via induced amplification of solvent relaxation based on superparamagnetic nanoparticles. The first component of this research was the fabrication and testing of two different micro-coil ({micro}-coil) platforms: namely a planar spiral NMR {micro}-coil and a cylindrical solenoid NMR {micro}-coil. These fabrication techniques are described along with the testing of the NMR performance for the individual coils. The NMR relaxivity for a series of water soluble FeMn oxide nanoparticles was also determined to explore the influence of the nanoparticle size on the observed NMR relaxation properties. In addition, The use of commercially produced superparamagnetic iron oxide nanoparticles (SPIONs) for amplification via NMR based relaxation mechanisms was also demonstrated, with the lower detection limit in number of SPIONs per nanoliter (nL) being determined.
Date: November 1, 2006
Creator: Clewett, C. F. M.; Adams, David Price; Fan, Hongyou; Williams, John D.; Sillerud, Laurel O.; Alam, Todd Michael et al.
Partner: UNT Libraries Government Documents Department

Special Report on "Allegations of Conflict of Interest Regarding Licensing of PROTECT by Argonne National Laboratory"

Description: In February 2009, the Office of Inspector General received a letter from Congressman Mark Steven Kirk of Illinois, which included constituent allegations that an exclusive technology licensing agreement by Argonne National Laboratory was tainted by inadequate competition, conflicts of interest, and other improprieties. The technology in question was for the Program for Response Options and Technology Enhancements for Chemical/Biological Terrorism, commonly referred to as PROTECT. Because of the importance of the Department of Energy's technology transfer program, especially as implementation of the American Recovery and Reinvestment Act matures, we reviewed selected aspects of the licensing process for PROTECT to determine whether the allegations had merit. In summary, under the facts developed during our review, it was understandable that interested parties concluded that there was a conflict of interest in this matter and that Argonne may have provided the successful licensee with an unfair advantage. In part, this was consistent with aspects of the complaint from Congressman Kirk's constituent.
Date: August 1, 2009
Partner: UNT Libraries Government Documents Department

Outreach and Education in the Life Sciences A Case Study of the U.S. Department of Energy National Laboratories

Description: This project was intended to assess the impact of the U.S. Department of Energy’s National Nuclear Security Agency (DOE/NNSA) -sponsored education and outreach activities on the Biological Weapons Convention (BWC) in DOE national laboratories. Key activities focused on a series of pilot education and outreach workshops conducted at ten national laboratories. These workshops were designed to increase awareness of the BWC, familiarize scientists with dual-use concerns related to biological research, and promote the concept of individual responsibility and accountability
Date: March 15, 2010
Creator: Weller, Richard E.; Burbank, Roberta L. & Mahy, Heidi A.
Partner: UNT Libraries Government Documents Department

Risk-based decision making for staggered bioterrorist attacks : resource allocation and risk reduction in "reload" scenarios.

Description: Staggered bioterrorist attacks with aerosolized pathogens on population centers present a formidable challenge to resource allocation and response planning. The response and planning will commence immediately after the detection of the first attack and with no or little information of the second attack. In this report, we outline a method by which resource allocation may be performed. It involves probabilistic reconstruction of the bioterrorist attack from partial observations of the outbreak, followed by an optimization-under-uncertainty approach to perform resource allocations. We consider both single-site and time-staggered multi-site attacks (i.e., a reload scenario) under conditions when resources (personnel and equipment which are difficult to gather and transport) are insufficient. Both communicable (plague) and non-communicable diseases (anthrax) are addressed, and we also consider cases when the data, the time-series of people reporting with symptoms, are confounded with a reporting delay. We demonstrate how our approach develops allocations profiles that have the potential to reduce the probability of an extremely adverse outcome in exchange for a more certain, but less adverse outcome. We explore the effect of placing limits on daily allocations. Further, since our method is data-driven, the resource allocation progressively improves as more data becomes available.
Date: October 1, 2009
Creator: Lemaster, Michelle Nicole; Gay, David M. (Sandia National Laboratories, Albuquerque, NM); Ehlen, Mark Andrew (Sandia National Laboratories, Albuquerque, NM); Boggs, Paul T. & Ray, Jaideep
Partner: UNT Libraries Government Documents Department