Evidence for a role of the multifunctional calcium/calmodulin-dependent protein kinase II in insulin secretion
Description: Calcium/calmodulin-dependent protein kinase II (CaM kinase II) is demonstrated to exist in the ß-cell and immunopecipitation. Glucose and potassium significantly stimulate the rapid autophosphorylation of CaM kinase II and proportionally induce autonomous activity of the kinase in a dose-dependent manner that parallels insulin secretion. The activation of CaM kinase II, alloxan, KN-62 and KN-93, suggest that the enzyme is an integral component of insulin secretion and/or related processes in the β-cell.
Date: December 1993
Creator: Wenham, Robert M. (Robert Michael)
Partner: UNT Libraries