Multiple Whole Genome Alignments Without a Reference Organism
Description:
Multiple sequence alignments have become one of the most commonly used resources in genomics research. Most algorithms for multiple alignment of whole genomes rely either on a reference genome, against which all of the other sequences are laid out, or require a one-to-one mapping between the nucleotides of the genomes, preventing the alignment of recently duplicated regions. Both approaches have drawbacks for whole-genome comparisons. In this paper we present a novel symmetric alignment algorit…
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Date:
January 16, 2009
Creator:
Dubchak, Inna; Poliakov, Alexander; Kislyuk, Andrey & Brudno, Michael
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UNT Libraries Government Documents Department