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Partitioning of /sup 238/Pu, /sup 239/Pu, and /sup 241/Am in skeleton and liver of United States transuranium registry autopsy cases

Description: The distribution and concentration of the transuranic elements in humans was studied through analysis of tissues collected from occupationally exposed persons at autopsy. This report describes the results of the evaluation of data from registrants with measurable concentrations of plutonium and americium who had contributed bone and liver specimens to the United States Transuranium Registry. (ACR)
Date: June 1, 1986
Creator: Kathren, R.L.
Partner: UNT Libraries Government Documents Department

Effect of physico-chemical properties on metabolism of transuranium oxide aerosols inhaled by beagle dogs

Description: The oxides of four transuranium isotopes ($sup 238$Pu, $sup 239$Pu, $sup 241$Am, and $sup 244$Cm), prepared by identical methods of calcining the oxalate at 750$sup 0$C for two hours, had different physico-chemical properties. For all four oxides the density ranges from 9.8 to 11.4 g cm$sup -3$ and initial ultrafilterability (suspended fraction of activity less than 24 A) varied from 0.002 percent for $sup 239$PuO$sub 2$ to 2.24 percent for $sup 238$PuO$sub 2$. Dogs were exposed by nose-only techniques to aerosols generated by nebulizing water suspensions of the oxides. The dogs were sacrificed at intervals from one week to about a year postexposure. The rate of translocation of material from lung to other tissues increased from $sup 239$Pu to $sup 238$Pu to $sup 241$Am to $sup 244$Cm, possibly reflecting the decrease in mean particle size from an MMD of 0.7 $mu$m to $sup 239$PuO$sub 2$ to 0.6 $mu$m for $sup 238$PuO$sub 2$ to 0.4 $mu$m for $sup 241$AmO$sub 2$ to 0.1 $mu$m for $sup 244$CmO/sub x/. Accumulation of the isotopes in the liver and skeleton as a percentage of final body burden was 1 percent $sup 239$Pu and 7 to 23 percent for $sup 238$Pu at about a year postexposure, while at 270 days postexposure, values were 40 percent for $sup 241$Am and 40 to 30 percent for $sup 244$Cm. (auth)
Date: January 1, 1975
Creator: Craig, D.K.; Park, J.F. & Ryan, J.L.
Partner: UNT Libraries Government Documents Department

Translocation dynamics of 239-plutonium

Description: >Thesis. The translocation dynamics of /sup 239/Pu(NO/sub 3/)/sub 4/ and /sup 239/PuO/sub 2/ from ulated puncture wounds in the paws of beagle dogs were studied. The difference between the more soluble Pu(NO/sub 3/)/sub 4/ form the insoluble high fired PuO/sub 2 particles was assumed to bring about highly differing translocation dynamics from the wound site, through lymphatic channels into the system's circulation and to organs of deposition and of excretion. There was rapid movement of Pu from the paw to the first major lymph node with a resulting buildup and regression pattern for activity within the node. Differential translocation, concentration, retention, and excretion of Pu and Am were demonstrated with both chemical forms. The effectiveness of DTPA administration for Pu removal from the body was dependent on the chemical form of the Pu contaminant. ( CH)
Date: October 1, 1973
Creator: Bistline, R.W.
Partner: UNT Libraries Government Documents Department