Description: The studies proposed in this project are to define thresholds in cell signaling pathways that are required for cellular transformation and may be targeted by low-dose radiation. Defining thresholds in transformation-related signal transduction pathways that are sensitive to low-dose radiation would be an important advancement in risk assessment and could be used to demonstrate nonlinear relationships between low-dose radiation and cancer.
Date: June 1, 2000
Creator: Weber, Thomas J.; Colburn, Nancy H. & Bowman, Michael K.
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