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Evaluation of structure effects on the pharmacological behavior of radioiodinated phenylpentadecanoic acids

Description: For studying the pharmacokinetic behaviour of fatty acids with different chemical structures four STI-labelled compounds, i.e., the ortho and para STI-isomers of 15-phenylpentadecanoic acid (IPPA) and 3-methyl-15-phenylpentadecanoic acid were prepared and the organ distribution determined in mice. The results show a significant decrease of the maximal heart uptake for the two ortho compounds. Further, the hypothesis of a blocked metabolism as an effect of the US -methylation could not be confirmed. Both US -methylated compounds show a biexponential elimination behavior from the heart. 5 refs., 2 figs.
Date: January 1, 1986
Creator: Knapp, F.F. Jr.; Goodman, M.M.; Machulla, H.J.; Knust, E.J.; Kartje, M. & Vyska, K.
Partner: UNT Libraries Government Documents Department