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A Validated High-Let Radiation Specific Biomarker in the Mayak Worker Cohort

Description: Our goal (see Project Objectives) is to deliver a dosimetry system which will enable both a Pu body burden of 0.3 kBq, and a 30 cGy {gamma} ray dose, to be separately estimated with a confidence limit of {+-}30%. In terms of the numbers analyzed and the data we have accrued, we have direct quantitative evidence that we are on track to providing such a comprehensive independent dosimetry system for Mayak workers. We had previously demonstrated that intra-chromosomal aberrations measured in peripheral blood lymphocytes can be used as a sensitive long-lived low-background quantitative biomarker of densely-ionizing radiation dose in individuals exposed many years ago. We propose to calibrate the system such that it can be used to estimate both the densely-ionizing internal plutonium exposure and the sparsely-ionizing external exposure in Mayak workers exposed to different combinations of these over a prolonged period, mostly many years ago. Our objective is to deliver a dosimetry system (set of calibration parameters) which will enable both a comparatively low Pu body burden of 0.3 kBq, and a comparatively low 30 cGy {gamma} ray dose (one of these or both of these) to be estimated with a confidence limit of {+-}30% (higher doses will of course be estimated with smaller confidence intervals and still lower doses with larger confidence intervals). (1) Draw blood, make metaphase slides and measure numbers of intra- and inter-chromosome aberrations (using the mBAND and mFISH techniques) in - (A) 255 healthy former Mayak workers who were exposed various combinations of internal and external exposures. The individuals were chosen from the data base of healthy former workers through computer simulation to optimize estimates of the dosimetry parameters. The individuals have both internal and external dose estimates from the SUBI Doses-99 system. (B) 85 healthy non-exposed controls with ages, gender, and smoking status, ...
Date: December 11, 2006
Creator: David J. Brenner, Ph.D., D.Sc. & Tamara Azizova, M.D.
Partner: UNT Libraries Government Documents Department