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Barbituric Acids. V. 5-substituted-mercapto Derivatives of 5-isoamylbarbituric Acid

Description: Since no mention has been found in the literature of any 5-substituted mercapto-5-alkyl derivatives of barbituric acid, it was thought to be of interest to prepare a series of compounds containing sulfur attached directly to the barbituric acid nucleus. 5-substituted mercapto-5-isoamylbarbituric acids were chosen as representative of barbituric acids in which the alkyl group has a fairly high molecular weight.
Date: August 1952
Creator: Peterson, Paul Eugene
Partner: UNT Libraries

Infrared Studies of Anions of Barbituric Acids

Description: As long ago as 1881, it was realized that a functional group of atoms in a molecule would cause an absorption band to appear at a particular frequency in the infrared spectrum of the molecule. In more recent years, the concept of characteristic group frequencies has become firmly established and has resulted in the present widespread use of infrared spectroscopy. There appear to have been relatively few studies of infrared absorption of organic acids as compared with their salts.
Date: August 1960
Creator: Barnhart, Richard Lee
Partner: UNT Libraries

Barbituric Acids. VIII. 5-substituted-5-(1-pyrrolidyl)barbituric Acids

Description: The purpose of this investigation then was the preparation of a series of 5-substituted-5-(1-pyrrolidyl)barbituric acids in which R would consist of alkyl groups ranging in size from methyl to amyl, and other groups such as phenyl and benzyl. These compounds are to be tested elsewhere for hypnotic and anticonvulsant activity.
Date: 1957
Creator: Compton, Ross Davis
Partner: UNT Libraries

Synthesis of some 1-Substituted-2-Methylnaphthimidazole-4,9-Diones

Description: Imidazole derivatives of 1,4-naphthoquinones are found to have biological activity which interferes with the utilization of vitamin K or of the purines since they have groups common to these two classes of compounds. This thesis shows the preparation of some 1-substituted-naphthimidazole-4,9-diones for possible biological activity.
Date: August 1957
Creator: Peterson, Harold W.
Partner: UNT Libraries

Hydantoins as Anticonvulsants. VIII. 5-Alkylmercapto Derivatives of 3-Methyl-5-Phenylhydantoin

Description: Recent years have seen a rapid increase in the search for new compounds to be employed in the treatment of convulsions associated with epilepsy and related ailments. The properties desired are a higher degree of effectiveness and lower toxicity than those already in use. This thesis describes the effect of methylation of the 5-alkylmercapto-5-phenylhydantoins.
Date: January 1954
Creator: Dick, Clarence Reinhardt
Partner: UNT Libraries

Hydantoins as Anticonvulsants. VI. 5-Substituted-Alkoxy Derivatives of 5-Phenylhydantoin

Description: No derivatives of 5-phenylhydantoin with an oxygen atom attached directly in the five position of the hydantoin nucleus have been found in the literature. It was therefore considered of interest to synthesize a series of compounds of this type to determine the effect of the change of the position of the oxygen atom on anticonvulsant activity.
Date: January 1954
Creator: Hoffman, James Rucker
Partner: UNT Libraries

Barbituric Acids. VII. 5-alkyl-derivatives of 5-ethoxy-barbituric Acid

Description: A great deal of research has been devoted in recent years to the search for new drugs for the treatment of epilepsy and related convulsive disorders. This emphasis is occasioned by the fact that no one drug is effective for all patients, and also by the fact that the toxicity of a drug varies considerably from one patient to another. Among the most effective drugs are certain members of the hydantoin and barbituric acid series. For some time there has been in progress in this laboratory an investigation of members of these two series in which a hetro atom attached directly to the hetrocyclic nucleus is introduced into the side chain at position five of these two series.
Date: January 1955
Creator: Hyde, Harold Wayne
Partner: UNT Libraries

The Incidence of Escherichia Coli and other Coliform Organisms on Seventy-One Samples of Fresh Fruits and Vegetables Purchased from Eight Grocery Stores in Denton, Texas

Description: This investigation has for its aim the explanation of the incidence of colon bacteria on a number of food samples purchased in grocery stores of Denton, Texas, by an analysis of correlative sanitary factors.
Date: 1945
Creator: Scoggin, Frances Grammar
Partner: UNT Libraries

Hydantoin Derivatives as Anticonvulsants. I. 5-Cyclohexylalkyl-5-(2-Thienyl)Hydantoins

Description: The study herein described represents a continuation of the work on 5-(2-thienyl)-5-substituted hydantoins which has been in progress in the laboratories of the North Texas State College for the past several years. It has for its purpose the study of the effect of lengthening the carbon chain connecting a cyclohexyl radical to 5-(2-thienyl)hydantoin in the 5- position.
Date: 1949
Creator: Baker, Andy Albert
Partner: UNT Libraries

An Application of the Reformatsky Reaction to the Thiophene Series of Compounds

Description: In view of the increasing importance of thiophene derivatives as chemotherapeutic agents, it was considered of interest to apply the Reformatsky reaction to the synthesis of compounds containing the thiophene nucleus with the thought that these might serve as intermediates for further syntheses.
Date: 1949
Creator: Hicks, Howard A.
Partner: UNT Libraries