Search Results

Advanced search parameters have been applied.
open access

Fast Tree: Computing Large Minimum-Evolution Trees with Profiles instead of a Distance Matrix

Description: Gene families are growing rapidly, but standard methods for inferring phylogenies do not scale to alignments with over 10,000 sequences. We present FastTree, a method for constructing large phylogenies and for estimating their reliability. Instead of storing a distance matrix, FastTree stores sequence profiles of internal nodes in the tree. FastTree uses these profiles to implement neighbor-joining and uses heuristics to quickly identify candidate joins. FastTree then uses nearest-neighbor inte… more
Date: July 31, 2009
Creator: N. Price, Morgan; S. Dehal, Paramvir & P. Arkin, Adam
Partner: UNT Libraries Government Documents Department
Back to Top of Screen