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Inborn anemias in mice. Progress report, 1 May 1977--31 July 1978

Description: Hereditary anemias of mice have been the chief objects of investigation. At present under study are four macrocytic anemias, four hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, and the autoimmune hemolytic anemia of NZB. Each of these blood dyscrasias is caused by the action of a unique mutant gene, which determines the structure of different intracellular molecules, and thus controls a different metabolic process. Thus our wide range of different hereditary anemias has considerable potential for uncovering many different aspects of hemopoietic homeostatic mechanisms in the mouse. Each anemia is studied through: characterization of peripheral blood values, determinations of radiosensitivity under a variety of conditions, measurements of iron metabolism and heme synthesis, histological and biochemical study of blood-forming tissue, functional tests of the stem cell component, examination of responses to erythroid stimuli, and transplantation of tissue between individuals of differently affected genotypes. Considerable effort is devoted to perfection of hematologic, cell culture, and transplant methods to make these techniques useful in dealing with special problems associated with abnormal function.
Date: August 1, 1978
Creator: Bernstein, S.E. & Russell, E.S.
Partner: UNT Libraries Government Documents Department

Inborn anemias in mice. Progress report, 1 August 1979-15 July 1980

Description: Four macrocytic anemias, four hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, an ..cap alpha..-thalassemia, and a new target-cell anemia are under investigation in mice. Each of these blood dyscrasias is caused by the action of a unique mutant gene, which determines the structure of different intracellular molecules, and thus controls a different metabolic process. Thus the wide range of different hereditary anemias has considerable potential for uncovering many different aspects of hemopoietic homeostatic mechanisms in the mouse. Each anemia is studied through: (a) characterization of peripheral blood values; (b) determinations of radiosensitivity under a variety of conditions; (c) measurements of iron metabolism and heme synthesis; (d) histological and biochemical study of blood-forming tissue; (e) functional tests of the stem cell component; (f) examination of responses to erythroid stimuli; and (g) transplantation of tissue between individuals of differently affected genotypes.
Date: August 1, 1980
Creator: Bernstein, S.E. & Russell, E.S.
Partner: UNT Libraries Government Documents Department

Inborn anemias in mice. Progress report to accompany twenty-first renewal proposal, 1 May 1975--30 April 1976

Description: Progress is reported on studies on hereditary anemias of mice. At present under study are four macrocytic anemias, four hemolytic anemias, nonhemolytic microcytic anemia, transitory siderocytic anemia, sex-linked iron-transport anemia, and the autoimmune hemolytic anemia of NZB. Each of these blood dyscrasias is caused by the action of a unique mutant gene, each of which determines the structure of different intracellular molecules, and thus controls a different metabolic process. Thus our wide range of different hereditary anemias has considerable potential for uncovering many different aspects of hemopoietic homeostatic mechanisms in the mouse.
Date: May 15, 1976
Creator: Russell, E. S. & Bernstein, S. E.
Partner: UNT Libraries Government Documents Department

Inborn anemias in mice. Comprehensive progress report to accompany twenty-first renewal proposal, 1 May 1973--30 April 1976

Description: Progress is reported on the delineation of inborn anemias of the laboratory mouse, carried out by preparation of genetically homogeneous stocks segregating only for anemia-producing genes; by descriptions of each condition at all stages in the life history; by determination of tissue-sites of primary gene action through transplantation and parabiosis experiments; by analysis of reactions of normal and anemic mice to a variety of stressful stimuli, including x-irradiation and hypoxia; and by histological and biochemical study of normal vs. abnormal blood-forming tissue. At present 12 single-gene induced anemias are known in the mouse, plus one with multifactorial inheritance.
Date: May 1, 1976
Creator: Russell, E. S. & Bernstein, S. E.
Partner: UNT Libraries Government Documents Department