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[Informational document: New Infromation on didanosine]

Description: A note to physicians from the Division of Acquired Immunodeficiency Syndrome (AIDS) at the National Institute of Health requesting for doctors and clinics to refer HIV positive patients to didanosine (ddI) trials as promptly as possible.
Date: July 30, 1990
Creator: National Institutes of Health (U.S.)
Partner: UNT Libraries Special Collections

Biological neutron scattering: Now and the future

Description: Neutrons have an important role to play in structural biology. Neutron crystallography, small-angle neutron scattering and inelastic neutron scattering techniques can all contribute unique information on biomolecular structures. In particular, solution scattering techniques can give critical information on the conformations an dispositions of the components of complex assemblies under a wide variety of relevant conditions. The power of these methods are demonstrated for examples by protein/DNA complexes, and Ca{sup 2+}- binding proteins complexed with their regulatory targets. In addition, we demonstrate the utility of a new structural approach suing neutron resonance scattering. The impact of biological neutron scattering to date has been constrained principally by the available fluxes at neutron sources and the true potential of these approaches will only be realized with the development of new more powerful neutron sources.
Date: June 1, 1996
Creator: Trewhella, J.
Partner: UNT Libraries Government Documents Department

Accelerator System Model (ASM) user manual with physics and engineering model documentation. ASM version 1.0

Description: The Accelerator System Model (ASM) is a computer program developed to model proton radiofrequency accelerators and to carry out system level trade studies. The ASM FORTRAN subroutines are incorporated into an intuitive graphical user interface which provides for the {open_quotes}construction{close_quotes} of the accelerator in a window on the computer screen. The interface is based on the Shell for Particle Accelerator Related Codes (SPARC) software technology written for the Macintosh operating system in the C programming language. This User Manual describes the operation and use of the ASM application within the SPARC interface. The Appendix provides a detailed description of the physics and engineering models used in ASM. ASM Version 1.0 is joint project of G. H. Gillespie Associates, Inc. and the Accelerator Technology (AT) Division of the Los Alamos National Laboratory. Neither the ASM Version 1.0 software nor this ASM Documentation may be reproduced without the expressed written consent of both the Los Alamos National Laboratory and G. H. Gillespie Associates, Inc.
Date: July 1993
Partner: UNT Libraries Government Documents Department

National flow cytometry and sorting research resource. Annual progress report, July, 1, 1994--June 30, 1995, Year 12

Description: Research progress utilizing flow cytometry is described. Topics include: rapid kinetics flow cytometry; characterization of size determinations for small DNA fragments; statistical analysis; energy transfer measurements of molecular confirmation in micelles; and enrichment of Mus spretus chromosomes by dual parameter flow sorting and identification of sorted fractions by fluorescence in-situ hybridization onto G-banded mouse metaphase spreads.
Date: April 27, 1995
Creator: Jett, J. H.
Partner: UNT Libraries Government Documents Department

Developments in functional neuroimaging techniques

Description: A recent review of neuroimaging techniques indicates that new developments have primarily occurred in the area of data acquisition hardware/software technology. For example, new pulse sequences on standard clinical imagers and high-powered, rapidly oscillating magnetic field gradients used in echo planar imaging (EPI) have advanced MRI into the functional imaging arena. Significant developments in tomograph design have also been achieved for monitoring the distribution of positron-emitting radioactive tracers in the body (PET). Detector sizes, which pose a limit on spatial resolution, have become smaller (e.g., 3--5 mm wide) and a new emphasis on volumetric imaging has emerged which affords greater sensitivity for determining locations of positron annihilations and permits smaller doses to be utilized. Electromagnetic techniques have also witnessed growth in the ability to acquire data from the whole head simultaneously. EEG techniques have increased their electrode coverage (e.g., 128 channels rather than 16 or 32) and new whole-head systems are now in use for MEG. But the real challenge now is in the design and implementation of more sophisticated analyses to effectively handle the tremendous amount of physiological/anatomical data that can be acquired. Furthermore, such analyses will be necessary for integrating data across techniques in order to provide a truly comprehensive understanding of the functional organization of the human brain.
Date: March 1, 1995
Creator: Aine, C.J.
Partner: UNT Libraries Government Documents Department

Protein kinesis: The dynamics of protein trafficking and stability

Description: The purpose of this conference is to provide a multidisciplinary forum for exchange of state-of-the-art information on protein kinesis. This volume contains abstracts of papers in the following areas: protein folding and modification in the endoplasmic reticulum; protein trafficking; protein translocation and folding; protein degradation; polarity; nuclear trafficking; membrane dynamics; and protein import into organelles.
Date: December 31, 1995
Partner: UNT Libraries Government Documents Department

The gene identification problem: An overview for developers

Description: The gene identification problem is the problem of interpreting nucleotide sequences by computer, in order to provide tentative annotation on the location, structure, and functional class of protein-coding genes. This problem is of self-evident importance, and is far from being fully solved, particularly for higher eukaryotes, Thus it is not surprising that the number of algorithm and software developers working in this area is rapidly increasing. The present paper is an overview of the field, with an emphasis on eukaryotes, for such developers.
Date: March 27, 1995
Creator: Fickett, J.W.
Partner: UNT Libraries Government Documents Department

59. Cold Spring Harbor symposium on quantitative biology: Molecular genetics of cancer

Description: Investigation of the mechanistic aspects of cancer has its roots in the studies on tumor viruses and their effects on cell proliferation, function, and growth. This outstanding progress was well documented in previous Cold Spring Harbor Symposia on Quantitative Biology. In the early to mid 1980s, progress on the development of chromosome mapping strategies and the accumulation of DNA probes that identified polymorphisms, encouraged by the international Human Genome Project, enabled the identification of other genes that contributed to familial inheritance of high susceptibility to specific cancers. This approach was very successful and led to a degree of optimism that one aspect of cancer, the multistep genetic process from early neoplasia to metastatic tumors, was beginning to be understood. It therefore seemed appropriate that the 59th Symposium on Quantitative Biology focus attention on the Molecular Genetics of Cancer. The concept was to combine the exciting progress on the identification of new genetic alterations in human tumor cells with studies on the function of the cancer gene products and how they go awry in tumor cells.
Date: December 31, 1994
Partner: UNT Libraries Government Documents Department

Patterning nanocrystals using DNA

Description: One of the goals of nanotechnology is to enable programmed self-assembly of patterns made of various materials with nanometer-sized control. This dissertation describes the results of experiments templating arrangements of gold and semiconductor nanocrystals using 2'-deoxyribonucleic acid (DNA). Previously, simple DNA-templated linear arrangements of two and three nanocrystals structures have been made.[1] Here, we have sought to assemble larger and more complex nanostructures. Gold-DNA conjugates with 50 to 100 bases self-assembled into planned arrangements using strands of DNA containing complementary base sequences. We used two methods to increase the complexity of the arrangements: using branched synthetic doublers within the DNA covalent backbone to create discrete nanocrystal groupings, and incorporating the nanocrystals into a previously developed DNA lattice structure [2][3] that self-assembles from tiles made of DNA double-crossover molecules to create ordered nanoparticle arrays. In the first project, the introduction of a covalently-branched synthetic doubler reagent into the backbone of DNA strands created a branched DNA ''trimer.'' This DNA trimer templated various structures that contained groupings of three and four gold nanoparticles, giving promising, but inconclusive transmission electron microscopy (TEM) results. Due to the presence of a variety of possible structures in the reaction mixtures, and due to the difficulty of isolating the desired structures, the TEM and gel electrophoresis results for larger structures having four particles, and for structures containing both 5 and 10 nm gold nanoparticles were inconclusive. Better results may come from using optical detection methods, or from improved sample preparation. In the second project, we worked toward making two-dimensional ordered arrays of nanocrystals. We replicated and improved upon previous results for making DNA lattices, increasing the size of the lattices to a length greater than 20 {micro}m, and collecting atomic force microscopy (AFM) images up to 30 {micro}m. We found the lattices' requirement of divalent magnesium cations ...
Date: September 1, 2003
Creator: Williams, Shara Carol
Partner: UNT Libraries Government Documents Department

Structural studies of conformational changes of proteins upon phosphorylation: Structures of activated CheY, CheY-N16-FliM complex, and AAA {sup +} ATPase domain of NtrC1 in both inactive and active states

Description: Protein phosphorylation is a general mechanism for signal transduction as well as regulation of cellular function. Unlike phosphorylation in eukaryotic systems that uses Ser/Thr for the sites of modification, two-component signal transduction systems, which are prevalent in bacteria, archea, and lower eukaryotes, use an aspartate as the site of phosphorylation. Two-component systems comprise a histidine kinase and a receiver domain. The conformational change of the receiver domain upon phosphorylation leads to signal transfer to the downstream target, a process that had not been understood well at the molecular level. The transient nature of the phospho-Asp bond had made structural studies difficult. The discovery of an excellent analogue for acylphosphate, BeF{sub 3}{sup -}, enabled structural study of activated receiver domains. The structure of activated Chemotaxis protein Y (CheY) was determined both by NMR spectroscopy and X-ray crystallography. These structures revealed the molecular basis of the conformational change that is coupled to phosphorylation. Phosphorylation of the conserved Asp residue in the active site allows hydrogen bonding of the T87 O{gamma} to phospho-aspartate, which in turn leads to the rotation of Y106 into the ''in'' position (termed Y-T coupling). The structure of activated CheY complexed with the 16 N-terminal residues of FliM (N16-FliM), its target, was also determined by X-ray crystallography and confirmed the proposed mechanism of activation (Y-T coupling). First, N16-FliM binds to the region on CheY that undergoes a significant conformational change. Second, the ''in'' position of Y106 presents a better binding surface for FliM because the sidechain of Y106 in the inactive form of CheY (''out'' position) sterically interferes with binding of N16-FliM. In addition to confirmation of Y-T coupling, the structure of the activated CheY-N16-FliM complex suggested that the N16-FliM might be sandwiched between CheY and the remainder of FliM to change the direction of flagellar rotation.
Date: April 10, 2003
Creator: Lee, Seok-Yong
Partner: UNT Libraries Government Documents Department

Noise propagation in iterative reconstruction algorithms with line searches

Description: In this paper we analyze the propagation of noise in iterative image reconstruction algorithms. We derive theoretical expressions for the general form of preconditioned gradient algorithms with line searches. The results are applicable to a wide range of iterative reconstruction problems, such as emission tomography, transmission tomography, and image restoration. A unique contribution of this paper comparing to our previous work [1] is that the line search is explicitly modeled and we do not use the approximation that the gradient of the objective function is zero. As a result, the error in the estimate of noise at early iterations is significantly reduced.
Date: November 15, 2003
Creator: Qi, Jinyi
Partner: UNT Libraries Government Documents Department

Nuclear actin and protein 4.1: Essential interactions during nuclear assembly in vitro

Description: Structural protein 4.1, which has crucial interactions within the spectin-actin lattice of the human red cell membrane skeleton, also is widely distributed at diverse intracellular sites in nucleated cells. We previously showed that 4.1 is essential for assembly of functional nuclei in vitro and that the capacity of 4.1 to bind actin is required. Here we report that 4.1 and actin colocalize in mammalian cell nuclei using fluorescence microscopy and, by higher resolution cell whole mount electron microscopy, are associated on nuclear filaments. We also devised a cell-free assay using Xenopus egg extract containing fluorescent actin to follow actin during nuclear assembly. By directly imaging actin under non-perturbing conditions, the total nuclear actin population is retained and is visualized in situ relative to intact chromatin. We detected actin initially when chromatin and nuclear pores began assembling. As the nuclear lamina assembled, but preceding DNA synthesis, a discrete actin network formed throughout the nucleus. Protein 4.1 epitopes also were detected when actin began to accumulate in nuclei, producing a diffuse coincident pattern. As nuclei matured, actin was detected both coincident with and also independent of 4.1 epitopes. To test whether acquisition of nuclear actin is required for nuclear assembly, the actin inhibitor latrunculin A was added to Xenopus egg extracts during nuclear assembly. Latrunculin A strongly perturbed nuclear assembly and produced distorted nuclear structures containing neither actin nor protein 4.1. Our results suggest that actin as well as 4.1 is necessary for nuclear assembly and that 4.1-actin interactions may be critical.
Date: June 11, 2003
Creator: Krauss, Sharon Wald; Chen, Cynthia; Penman, Sheldon & Heald, Rebecca
Partner: UNT Libraries Government Documents Department

Theoretical evaluation of the detectability of random lesions in bayesian emission reconstruction

Description: Detecting cancerous lesion is an important task in positron emission tomography (PET). Bayesian methods based on the maximum a posteriori principle (also called penalized maximum likelihood methods) have been developed to deal with the low signal to noise ratio in the emission data. Similar to the filter cut-off frequency in the filtered backprojection method, the prior parameters in Bayesian reconstruction control the resolution and noise trade-off and hence affect detectability of lesions in reconstructed images. Bayesian reconstructions are difficult to analyze because the resolution and noise properties are nonlinear and object-dependent. Most research has been based on Monte Carlo simulations, which are very time consuming. Building on the recent progress on the theoretical analysis of image properties of statistical reconstructions and the development of numerical observers, here we develop a theoretical approach for fast computation of lesion detectability in Bayesian reconstruction. The results can be used to choose the optimum hyperparameter for the maximum lesion detectability. New in this work is the use of theoretical expressions that explicitly model the statistical variation of the lesion and background without assuming that the object variation is (locally) stationary. The theoretical results are validated using Monte Carlo simulations. The comparisons show good agreement between the theoretical predications and the Monte Carlo results.
Date: May 2003
Creator: Qi, Jinyi
Partner: UNT Libraries Government Documents Department

Autecology of Vibrio vulnificus and Vibrio parahaemolyticus in tropical waters

Description: Water and shellfish samples collected from estuaries, mangroves, and beaches along the coast of Puerto Rico were examined for Vibrio vulnificus and Vibrio parahaemolyticus. An array of water quality parameters were also measured simultaneous with bacteria sampling. Both species of vibrio were associated with estuary and mangrove locations, and neither was isolated from sandy beaches. Densities of V. vulnificus were negatively correlated with salinity, 10--15 ppt being optimal. V. parahaemolyticus was isolated from sites with salinities between 20 and 35 ppt, the highest densities occurring at 20 ppt. Densities of Vibrio spp. and V. parahaemolyticus for a tropical estuary surpassed those reported for temperate estuaries by several orders of magnitude. Both densities of total Vibrio spp. and V. parahaemolyticus in the water were directly related to densities of fecal coliforms, unlike V. vulnificus. The incidence of ONPG(+) strains among sucrose({minus}) Vibrio spp. served as an indicator of the frequency of V. vulnificus in this group. More than 63% of the V. vulnificus isolated were pathogenic. V. vulnificus and V. parahaemolyticus occupy clearly separate niches within the tropical estuarine-marine ecosystem.
Date: Spring 1988
Creator: Rivera, S.; Lugo, T. & Hazen, T. C.
Partner: UNT Libraries Government Documents Department

Subspace angles: a metric for comparisons in EEG and MEG

Description: In forward head modeling, various approximations are made in order to keep the problem tractable. Simplifications can yield models ranging from simple spherical models to multi-tessellated arbitrary surfaces in a boundary element model (BEM). Spherical head models differ in the number of shells and the assumed conductivities. Other assumptions in the BEM include the choice of basis sets, such as constant, linear, or quadratic variations of the voltages across the individual areal elements, or the selection of error-weighting method, such as collocation, Galerkin, or `direct` methods. Numerical versus analytic integration can also yield numerical differences. These differences in parameters and approximations can yield models whose external fields (EEG potentials or MEG magnetic fields) differ for the same internal source configuration. Quantitative measures are needed to determine if these differences are significant.
Date: July 1, 1996
Creator: Mosher, J. C.
Partner: UNT Libraries Government Documents Department

Bayesian analysis of MEG visual evoked responses

Description: The authors developed a method for analyzing neural electromagnetic data that allows probabilistic inferences to be drawn about regions of activation. The method involves the generation of a large number of possible solutions which both fir the data and prior expectations about the nature of probable solutions made explicit by a Bayesian formalism. In addition, they have introduced a model for the current distributions that produce MEG and (EEG) data that allows extended regions of activity, and can easily incorporate prior information such as anatomical constraints from MRI. To evaluate the feasibility and utility of the Bayesian approach with actual data, they analyzed MEG data from a visual evoked response experiment. They compared Bayesian analyses of MEG responses to visual stimuli in the left and right visual fields, in order to examine the sensitivity of the method to detect known features of human visual cortex organization. They also examined the changing pattern of cortical activation as a function of time.
Date: April 1, 1999
Creator: Schmidt, D.M.; George, J.S. & Wood, C.C.
Partner: UNT Libraries Government Documents Department

A method for locating regions containing neural activation at a given confidence level from MEG data

Description: The MEG inverse problem does not have a general, unique solution. Unless restrictive model assumptions are made, there are generally many more free parameters than measurements and there exist silent sources - current distributions which produce no external magnetic field. By weighting solutions according to how well each fits our prior notion about what properties good solutions should have, it may be possible to obtain a single current distribution that best fits the data and our expectations. However, in general there will still exist a number of different current distributions which fit both the data and our prior expectations sufficiently well. For example, a simulated data set based on a single or several dipoles can generally be fit equally well by a distributed current minimum-norm reconstruction. In experimental data it is often possible to find a relatively small number of dipoles which both fit the data and have a norm not much larger than that of the minimum-norm solution. Moreover, the few-dipole solutions often have currents in different regions than the corresponding minimum-norm solution. Because there exist well-fitting current distributions which may have current in significantly different locations, it can be misleading to infer locations of stimulus-correlated neural activity based on a single, best-fitting current distribution. we demonstrate here a method for inferring the location and number of regions containing neural activation by considering all possible current distributions within a given model (not just the most likely one) weighted according to how well each fits both the data and our prior expectations.
Date: February 1, 1996
Creator: Schmidt, D.M. & George, J.S.
Partner: UNT Libraries Government Documents Department

A skull-based multiple dipole phantom for EEG and MEG studies

Description: A versatile phantom for use in evaluating forward and inverse methods for MEG and EEG has been designed and is currently being constructed. The phantom consists of three major components: (i) a 32-element cur- rent dipole array, (ii) a PC-controlled dipole driver with 32 isolated channels allowing independent control of each dipole, (iii) spherical and human-skull mounts in which the dipole array is placed. Materials were selected throughout the phantom to produce minimal field distortions and artifacts to enable acquisition of high quality EEG and MEG data. The dipoles are made from a rigid narrow (0.84 mm) stainless steel coax cable. The dipole drivers can be configured as either current or voltage sources, are independently programmable and fully isolated, and are capable of producing arbitrary bipolar waveforms up to a 200 Hz bandwidth. The spherical mount is a single shell sphere filled with conductive gelatin. The human skull mount has three shells: ``brain`` (conducting gelatin), ``skull`` (the skull is impregnated with a low conductivity conducting gelatin), and ``scalp`` (a thin layer of rubber latex mixed with NaCl to achieve a conductivity matched to the brain). The conductivities will be adjusted to achieve approximately an 80:1:80 ratio. Data collected to date from the spherical phantom shows excellent agreement between measured surface potentials and that predicted from theory (27 of the 32 dipoles give better than 99.9% rms fit) and negligible leakage between dipoles. We are currently completing construction of the skull mount.
Date: July 1, 1996
Creator: Spencer, M.E.; Leahy, R.M. & Mosher, J.C.
Partner: UNT Libraries Government Documents Department

EEG and MEG source localization using recursively applied (RAP) MUSIC

Description: The multiple signal characterization (MUSIC) algorithm locates multiple asynchronous dipolar sources from electroencephalography (EEG) and magnetoencephalography (MEG) data. A signal subspace is estimated from the data, then the algorithm scans a single dipole model through a three-dimensional head volume and computes projections onto this subspace. To locate the sources, the user must search the head volume for local peaks in the projection metric. Here we describe a novel extension of this approach which we refer to as RAP (Recursively APplied) MUSIC. This new procedure automatically extracts the locations of the sources through a recursive use of subspace projections, which uses the metric of principal correlations as a multidimensional form of correlation analysis between the model subspace and the data subspace. The dipolar orientations, a form of `diverse polarization,` are easily extracted using the associated principal vectors.
Date: December 31, 1996
Creator: Mosher, J.C. & Leahy, R.M.
Partner: UNT Libraries Government Documents Department

Source localization using recursively applied and projected (RAP) MUSIC

Description: A new method for source localization is described that is based on a modification of the well known multiple signal classification (MUSIC) algorithm. In classical MUSIC, the array manifold vector is projected onto an estimate of the signal subspace, but errors in the estimate can make location of multiple sources difficult. Recursively applied and projected (RAP) MUSIC uses each successively located source to form an intermediate array gain matrix, and projects both the array manifold and the signal subspace estimate into its orthogonal complement. The MUSIC projection is then performed in this reduced subspace. Using the metric of principal angles, the authors describe a general form of the RAP-MUSIC algorithm for the case of diversely polarized sources. Through a uniform linear array simulation, the authors demonstrate the improved Monte Carlo performance of RAP-MUSIC relative to MUSIC and two other sequential subspace methods, S and IES-MUSIC.
Date: March 1, 1998
Creator: Mosher, J.C. & Leahy, R.M.
Partner: UNT Libraries Government Documents Department

Scientist to scientist colloquium steering committee planning session. Summary report of the proceedings

Description: The reason for holding a scientific colloquium of this nature is to bring together the most active scientific researchers for cross-disciplinary exchanges. As one scientist commented, it is a way to compensate for over-specialization. As a scientist/administrator noted, it helps administrators to have access to high-level scientific information in a setting where they can ask stupid questions. At a meeting of between 80 and 100 people small group exchanges are possible, allowing more in-depth discussion. In five days of meetings, there are many opportunities for a great number of these exchanges. The Keystone Process facilitates intermingling across disciplines and encourages debate. Because this meeting is unlike discipline-specific meetings, presenters must write a talk specifically for an interdisciplinary audience, touching on various scientific and social implications of their work. They use this opportunity to practice addressing a broad audience which includes their peers from other /fields, university administrators, industry executives, government officials, and members of the media who will help bring forefront scientific findings to the public. This report discusses purpose, funding, and outcome of the colloquium.
Date: December 31, 1996
Partner: UNT Libraries Government Documents Department

High resolution x-ray fluorescence spectroscopy - a new technique for site- and spin-selectivity

Description: X-ray spectroscopy has long been used to elucidate electronic and structural information of molecules. One of the weaknesses of x-ray absorption is its sensitivity to all of the atoms of a particular element in a sample. Through out this thesis, a new technique for enhancing the site- and spin-selectivity of the x-ray absorption has been developed. By high resolution fluorescence detection, the chemical sensitivity of K emission spectra can be used to identify oxidation and spin states; it can also be used to facilitate site-selective X-ray Absorption Near Edge Structure (XANES) and site-selective Extended X-ray Absorption Fine Structure (EXAFS). The spin polarization in K fluorescence could be used to generate spin selective XANES or spin-polarized EXAFS, which provides a new measure of the spin density, or the nature of magnetic neighboring atoms. Finally, dramatic line-sharpening effects by the combination of absorption and emission processes allow observation of structure that is normally unobservable. All these unique characters can enormously simplify a complex x-ray spectrum. Applications of this novel technique have generated information from various transition-metal model compounds to metalloproteins. The absorption and emission spectra by high resolution fluorescence detection are interdependent. The ligand field multiplet model has been used for the analysis of K{alpha} and K{beta} emission spectra. First demonstration on different chemical states of Fe compounds has shown the applicability of site selectivity and spin polarization. Different interatomic distances of the same element in different chemical forms have been detected using site-selective EXAFS.
Date: December 1, 1996
Creator: Wang, Xin
Partner: UNT Libraries Government Documents Department

Studies of protein structure in solution and protein folding using synchrotron small-angle x-ray scattering

Description: Synchrotron small angle x-ray scattering (SAXS) has been applied to the structural study of several biological systems, including the nitrogenase complex, the heat shock cognate protein (hsc70), and lysozyme folding. The structural information revealed from the SAXS experiments is complementary to information obtained by other physical and biochemical methods, and adds to our knowledge and understanding of these systems.
Date: April 1, 1996
Creator: Chen, Lingling
Partner: UNT Libraries Government Documents Department

Lightweight computational steering of very large scale molecular dynamics simulations

Description: We present a computational steering approach for controlling, analyzing, and visualizing very large scale molecular dynamics simulations involving tens to hundreds of millions of atoms. Our approach relies on extensible scripting languages and an easy to use tool for building extensions and modules. The system is extremely easy to modify, works with existing C code, is memory efficient, and can be used from inexpensive workstations and networks. We demonstrate how we have used this system to manipulate data from production MD simulations involving as many as 104 million atoms running on the CM-5 and Cray T3D. We also show how this approach can be used to build systems that integrate common scripting languages (including Tcl/Tk, Perl, and Python), simulation code, user extensions, and commercial data analysis packages.
Date: September 1, 1996
Creator: Beazley, D.M. & Lomdahl, P.S.
Partner: UNT Libraries Government Documents Department