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Engineered Antibodies for Monitoring of Polynuclear Aromatic Hydrocarbons

Description: The objective is to develop improved antibody-based methods for detection of multiple polynuclear aromatic hydrocarbons (PAHs), to fill several needs in DOE's remediation, regulatory monitoring, ecotoxicology, and human health effects missions. Present-generation immunochemical detection methods have already proven to be useful and cost-effective in DOE applications. The problem being addressed is that the unique properties of PAHs make it impractical to generate antibodies with the required diversity, specificity and selectivity, by the previous techniques. The scientific goals are to determine the mechanisms by which antibodies bind PAHs, use genetic engineering and computational chemistry techniques to construct improved antibodies, and to devise methods for making immunochemical and instrumental analysis more compatible. The potential relevance is that our results should provide a rational basis by which immunochemical and other molecular recognition systems for PAHs and other large classes of toxic pollutants such as PCBs could be produced and deployed with substantially less cost, labor, and development time.
Date: June 1, 1999
Creator: Karu, Alexander E.; Roberts, Victoria & Li, Qingxiao
Partner: UNT Libraries Government Documents Department