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A New Perspective on the Afterlife Issue

Description: Article exploring the claim that human beings survive death as conscious entities, suggesting that a recording may persist of some aspects of one's life, of which some people may become aware under certain circumstances. The author examines whether this interpretation of phenomena believed oto be afterlife-related is plausible in terms of current scientific knowledge.
Date: Autumn 2003
Creator: Krishnan, V.
Partner: UNT Libraries

Near-Death Experiences: Evidence for Survival?

Description: Abstract: "This paper argues that the out-of-body experience (OBE) and other elements of a near-death experience (NDE), as well as the positive affects that accompany them, do not yeild conclusive evidence for survival after death. The OBE has features that suggest a physical basis for it, the other elements show the influence of cultural background, and positive affects may simply occur to conserve one's energy and prolong life. Other explanations for near-death elements, such as sensory deprivation, extrasensory perception, and eyeless sight, are addressed."
Date: Spring 1985
Creator: Krishnan, V.
Partner: UNT Libraries

Singlet Quenching of Tetraphenylporphyrin and its Metal Derivatives by Iron(III) Coordination Compounds

Description: This article reports on the singlet quenching of 5, 10, 15, 20-tetraphenylporphyrin (H₂TPP) and its magnesium(II) and zinc(II) derivatives (MgTPP and ZnTPP) by a series of iron(III) coordination compounds bearing different ligand systems.
Date: January 6, 1990
Creator: D'Souza, Francis & Krishnan, V.
Partner: UNT College of Arts and Sciences

Temperature dependence of protein hydration hydrodynamics by molecular dynamics simulations.

Description: The dynamics of water molecules near the protein surface are different from those of bulk water and influence the structure and dynamics of the protein itself. To elucidate the temperature dependence hydration dynamics of water molecules, we present results from the molecular dynamic simulation of the water molecules surrounding two proteins (Carboxypeptidase inhibitor and Ovomucoid) at seven different temperatures (T=273 to 303 K, in increments of 5 K). Translational diffusion coefficients of the surface water and bulk water molecules were estimated from 2 ns molecular dynamics simulation trajectories. Temperature dependence of the estimated bulk water diffusion closely reflects the experimental values, while hydration water diffusion is retarded significantly due to the protein. Protein surface induced scaling of translational dynamics of the hydration waters is uniform over the temperature range studied, suggesting the importance protein-water interactions.
Date: July 18, 2007
Creator: Lau, E Y & Krishnan, V V
Partner: UNT Libraries Government Documents Department

Application of NMR Methods to Identify Detection Reagents for Use in the Development of Robust Nanosensors

Description: Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful technique for studying bi-molecular interactions at the atomic scale. Our NMR lab is involved in the identification of small molecules, or ligands that bind to target protein receptors, such as tetanus (TeNT) and botulinum (BoNT) neurotoxins, anthrax proteins and HLA-DR10 receptors on non-Hodgkin's lymphoma cancer cells. Once low affinity binders are identified, they can be linked together to produce multidentate synthetic high affinity ligands (SHALs) that have very high specificity for their target protein receptors. An important nanotechnology application for SHALs is their use in the development of robust chemical sensors or biochips for the detection of pathogen proteins in environmental samples or body fluids. Here, we describe a recently developed NMR competition assay based on transferred nuclear Overhauser effect spectroscopy (trNOESY) that enables the identification of sets of ligands that bind to the same site, or a different site, on the surface of TeNT fragment C (TetC) than a known ''marker'' ligand, doxorubicin. Using this assay, we can identify the optimal pairs of ligands to be linked together for creating detection reagents, as well as estimate the relative binding constants for ligands competing for the same site.
Date: April 29, 2004
Creator: Cosman, M; Krishnan, V V & Balhorn, R
Partner: UNT Libraries Government Documents Department