Description: Adrenal uptake in rats of /sup 117m/Sn-labeled 23-(trimethyl stanna)-24-nor-5..cap alpha..-cholan-3..beta..-o1 is demonstrated. The adrenal:blood and adrenal:liver ratios were 33:1 and 9:1, only one day after intravenous administration. A variety of /sup 117m/Sn-labeled steroids with structural modifications were also prepared to determine their effects on the adrenal uptake of these unusual steroids. Structural features required for significant adrenal uptake were determined. The diffusion chamber assay system has been assessed as a means of investigating the toxicity and biological fate of trace elements from energy technologies. In a preliminary experiment, the cell population in chambers from rats exposed to As/sub 2/O/sub 3/ was inhibited 48% one day after treatment. The results of continuing studies with /sup 75/Se, /sup 11/C, and /sup 195m/Pt-labeled agents are also described. Several /sup 75/Se-labeled long-chain fatty acids were prepared to determine heart uptake. Selenium-75-labeled 9-selenapentacosanoic acid showed the highest uptake of the compounds investigated. Preliminary radiation dose estimates have been performed for several /sup 75/Se and /sup 123m/Te-labeled fatty acids. Tissue distribution and excretion data for /sup 75/Se-labeled 9-selenaheptadecanoic acid and /sup 123m/Te-labeled 9-telluraheptadecanoic acid indicate that the human liver would recieve the highest absorbed radiation dose.Tissue distribution studies in rats with a series of /sup 195m/Pt-labeled chloroammine complexes have demonstrated that the tissue distribution and excretion characteristics of the chlorcammine complexes closely parallel their physicochemical properties. Further patient studies have assessed the efficacy of emission computerized tomographic organ imaging with /sup 11/C-valine, and /sup 11/C-amino-cyclobutanecarboxylic acid (ACBC). (ERB)
Date: January 1, 1979
Creator: Knapp, F.F. Jr.
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