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Data base on animal mortality

Description: A data base on animal mortality has been compiled. The literature on LD/sub 50/ and the dose-response function for radiation-induced lethality, reflect several inconsistencies - primarily due to dose assignments and to analytical methods and/or mathematical models used. Thus, in order to make the individual experiments which were included in the data base as consistent as possible, an estimate of the uniform dose received by the bone marrow in each treatment group was made so that the interspec… more
Date: January 1, 1987
Creator: Jones, T.D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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CHORD simulation for insult assessment to the red bone marrow. [Photons, neutrons]

Description: Critical Human Organ Radiation Dosimetry (CHORD) probability density functions for A-P, P-A, bilateral, rotational, and isotropic incidence, plus simple depth-dose data, permit the rapid estimation of the radiation insult to the active red bone marrow system of the ICRP Reference Man. The CHORD concept follows the variations in the microscopic processes of absorption, attenuation, and scattering on a macroscopic level so that it is not necessary to attempt detailed calculations for each and eve… more
Date: September 1, 1976
Creator: Jones, T. D.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Radiation insult to the active bone marrow as predicted by a method of CHORDS. [Photons, neutrons]

Description: Critical Human Organ Radiation Dosimetry (CHORD) probability density functions for A-P, P-A, bilateral, rotational, and isotropic incidence, plus simple depth-dose data, permit the rapid estimation of the radiation insult to the active red bone marrow system of the ICRP Reference Man. The CHORD concept follows the variations in the microscopic processes of absorption, attenuation, and scattering on a macroscopic level so that it is not necessary to attempt detailed calculations for each and eve… more
Date: March 1, 1976
Creator: Jones, T. D.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Prediction of the mortality dose-response relationship in man

Description: Based upon an extensive data base including 100 separate animal studies, an estimate of the mortality dose-response relationship due to continuous photon radiation is predicted for 70 kg man. The model used in this prediction exercise includes fixed terms accounting for effects of body weight and dose rate, and random terms accounting for inter- and intra-species variation and experimental error. Point predictions and 95% prediction intervals are given for the LD/sub 05/, LD/sub 10/, LD/sub 25/… more
Date: January 1, 1987
Creator: Morris, M.D. & Jones, T.D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Use of bioassays in assessing health hazards from complex mixtures: A RASH analysis

Description: The Finney harmonic mean model for joint toxicity of ingredients in mixtures can be used to estimate the toxicity of the neat compound if one component can be substituted in potency-adjusted-doses for each of the other components. Chemical analysis data and relative potency values (computed according to the Rapid Screening of Hazard (RASH) method) were used to compare the toxicities as predicted from ingredients of cigarette smoke, PAHs in diesel exhaust, asphalt, coal tar, pitch, and creosote … more
Date: October 14, 1993
Creator: Jones, T. D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Modeling Multiple Causes of Carcinogenesis

Description: An array of epidemiological results and databases on test animal indicate that risk of cancer and atherosclerosis can be up- or down-regulated by diet through a range of 200%. Other factors contribute incrementally and include the natural terrestrial environment and various human activities that jointly produce complex exposures to endotoxin-producing microorganisms, ionizing radiations, and chemicals. Ordinary personal habits and simple physical irritants have been demonstrated to affect the i… more
Date: January 24, 1999
Creator: Jones, T.D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Dose-rate models for human survival after exposure to ionizing radiation

Description: This paper reviews new estimates of the L/sub 50/ in man by Mole and by Rotblat, the biological processes contributing to hematologic death, the collection of animal experiments dealing with hematologic death, and the use of regression analysis to make new estimates of human mortality based on all relevant animal studies. Regression analysis of animal mortality data has shown that mortality is dependent strongly on dose rate, species, body weight, and time interval over which the exposure is de… more
Date: January 1, 1986
Creator: Jones, T.D.; Morris, M.D. & Young, R.W.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Chemical cytotoxicity: a cancer promoter

Description: Study of available data from radiation- and chemically-induced carcinogenesis experiments has indicated a linear relationship between cancer incidence and cytotoxicity for a number of different systems. We hypothesize that the cytotoxic activity (individually or collectively) of a number of chemical carcinogens may act as a promotional stimulus, to generate an enlarging tumor mass from a small population of altered cells. A model is developed from which cancer risk of various chemicals can be e… more
Date: January 1, 1978
Creator: Griffin, G. D.; Jones, T. D. & Walsh, P. J.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Marrow cell kinetics model: Equivalent prompt dose approximations for two special cases

Description: Two simple algebraic expressions are described for approximating the equivalent prompt dose'' as defined in the model of Jones et al. (1991). These approximations apply to two specific radiation exposure patterns: (1) a pulsed dose immediately followed by a protracted exposure at relatively low, constant dose rate and (2) an exponentially decreasing exposure field.
Date: November 1, 1992
Creator: Morris, M. D. & Jones, T. D.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Marrow cell kinetics model: Equivalent prompt dose approximations for two special cases

Description: Two simple algebraic expressions are described for approximating the ``equivalent prompt dose`` as defined in the model of Jones et al. (1991). These approximations apply to two specific radiation exposure patterns: (1) a pulsed dose immediately followed by a protracted exposure at relatively low, constant dose rate and (2) an exponentially decreasing exposure field.
Date: November 1, 1992
Creator: Morris, M. D. & Jones, T. D.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A toolbox for health risk related decisions

Description: Development efforts since the late 1970s have resulted in a generalized method for ranking health hazards. This method provides the basis for a wide range of applications where decisions are needed for allocating resources on the basis of health risk considerations. It has been used for more than a decade to solve real problems, and it is supported by 23 publications in the open literature. The diversity of this generalized methodology allows us to provide support in a great number of problem a… more
Date: October 1, 1996
Creator: Easterly, C.E. & Jones, T.D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Radiobiological modelling with MarCell software

Description: Jones introduced a bone marrow radiation cell kinetics model with great potential for application in the fields of health physics, radiation research, and medicine. However, until recently, only the model developers have been able to apply it because of the complex array of biological and physical assignments needed for evaluation of a particular radiation exposure protocol. The purpose of this article is to illustrate the use of MarCell (MARrow CELL Kinetics) software for MS-DOS, a user-friend… more
Date: October 1, 1996
Creator: Hasan, J.S. & Jones, T.D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Animal mortality resulting from uniform exposures to photon radiations: Calculated LD/sub 50/s and a compilation of experimental data

Description: Studies conducted during the 1950s and 1960s of radiation-induced mortality to diverse animal species under various exposure protocols were compiled into a mortality data base. Some 24 variables were extracted and recomputed from each of the published studies, which were collected from a variety of available sources, primarily journal articles. Two features of this compilation effort are (1) an attempt to give an estimate of the uniform dose received by the bone marrow in each treatment so that… more
Date: December 1, 1986
Creator: Jones, T.D.; Morris, M.D.; Wells, S.M. & Young, R.W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Epidemiologic measures of risk as a basis for legal compensation

Description: The scientific basis for compensation of persons developing cancer who have a documented history of exposure to radiation or other carcinogens is an important legal issue. The measure Relative Attributable Risk (RAR) has been proposed as a basis for determining eligibility for compensation. The purpose of this report is to present results of an analysis of the magnitude and sources of uncertainty in the RAR measure. The range of 1/10/sup 6//rad-year to 6/10/sup 6//rad-year was chosen as a reaso… more
Date: January 1, 1983
Creator: Zeighami, E. A.; Walsh, P. J.; Morris, M. D. & Jones, T. D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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RApid Screening of Hazard analysis

Description: For synthetic fuels development, the Department of Energy was charged, in 1983, to ``justify the need to monitor specific unregulated substances and of providing threshold values above which these substances must be monitored.``
Date: June 1, 1993
Creator: Jones, T. D.; Morris, M. D. & Easterly, C. E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Modeling marrow damage from response data: Morphallaxis from radiation biology to benzene toxicity

Description: Consensus principles from radiation biology were used to describe a generic set of nonlinear, first-order differential equations for modeling of toxicity-induced compensatory cell kinetics in terms of sublethal injury, repair, direct killing, killing of cells with unrepaired sublethal injury, and repopulation. This cellular model was linked to a probit model of hematopoietic mortality that describes death from infection and/or hemorrhage between {approximately} 5 and 30 days. Mortality data fro… more
Date: December 1, 1995
Creator: Jones, T.D.; Morris, M.D. & Hasan, J.S.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Development and use of a fifteen year-old equivalent mathematical phantom for internal dose calculations. [Radiation dose distributions from /sup 99m/Tc-labeled compounds]

Description: The existence of a phantom based on anatomical data for the average fifteen-year-old provides for a proficient means of obtaining estimates of absorbed dose for children of that age. Dimensions representative of an average fifteen-year-old human, obtained from various biological and medical research, were transformed into a mathematical construct of idealized shapes of the exterior, skeletal system, and internal organs of a human. The idealization for an average adult presently in use by the In… more
Date: June 1, 1976
Creator: Jones, R. M.; Poston, J. W.; Hwang, J. L.; Jones, T. D. & Warner, G. G.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Use of short-term test systems for the prediction of the hazard represented by potential chemical carcinogens

Description: It has been hypothesized that results from short-term bioassays will ultimately provide information that will be useful for human health hazard assessment. Historically, the validity of the short-term tests has been assessed using the framework of the epidemiologic/medical screens. In this context, the results of the carcinogen (long-term) bioassay is generally used as the standard. However, this approach is widely recognized as being biased and, because it employs qualitative data, cannot be u… more
Date: October 1, 1990
Creator: Glass, L. R.; Jones, T. D.; Easterly, C. E. & Walsh, P. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Measurement of the asymmetry in the decay Antiomega+ ---> Antilambda K+ ---> anti-p pi+ K+

Description: The asymmetry in the {bar p} angular distribution in the sequential decay {bar {Omega}}{sup +} {yields} {bar {Lambda}}K{sup +} {yields} {bar p}{pi}{sup +}K{sup +} has been measured to be {bar {alpha}}{sub {Omega}}{bar {alpha}}{sub {Lambda}} = [+1.16{+-}0.18(stat){+-}0.17(syst)]x10{sup -2} using 1.89x10{sup 6} unpolarized {bar {Omega}}{sup +} decays recorded by the Hyper CP (E871) experiment at Fermilab. Using the known value of {alpha}{sub {Lambda}}, and assuming that {bar {alpha}}{sub {Lambda}… more
Date: January 1, 2006
Creator: Lu, L. C.; Burnstein, R. A.; Chakravorty, A.; Chen, Y. C.; Choong, W. S.; Clark, K. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Observation of parity violation in the Omega- ---> Lambda K- decay

Description: The {alpha} decay parameter in the process {Omega}{sup -} {yields} {Lambda}K{sup -} has been measured from a sample of 4.50 million unpolarized {Omega}{sup -} decays recorded by the HyperCP (E871) experiment at Fermilab and found to be [1.78 {+-} 0.19(stat) {+-} 0.16(syst)] x 10{sup -2}. This is the first unambiguous evidence for a nonzero {alpha} decay parameter, and hence parity violation, in the {Omega}{sup -} {Lambda}K{sup -} decay.
Date: May 1, 2005
Creator: Lu, L. C.; U., /Virginia; Burnstein, R. A.; Chakravorty, A.; Chen, Y. C.; Choong, W.-S. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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