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in creator/contributor: "Dzialowski, Ed"  
Results: 1 - 15
open access

Neurological Responses to a Glucose Diet in Caenorhabditis elegans

Description: TRPV channels play a role in both mammalian insulin signaling, with TRPV1 expression in pancreatic beta-cells, and in C. elegans insulin-like signaling through expression of OSM-9, OCR-1, and OCR-2 in stress response pathways. In response to a glucose-supplemented diet, C. elegans are know to have sensitivity to anoxic stress, exhibit chemotaxis attraction, and display reduced egg-laying rate. Transcriptome analysis reveals that glucose stimulates nervous system activity with increased transcri… more
Date: August 2017
Creator: Dumesnil, Dennis
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Shortened in Vivo Bioconcentration Factor Testing in Cyprinus Carpio

Description: Bioconcentration factor testing serves as the most valuable surrogate for the assessment of bioaccumulation. The assessment of potentially harmful chemicals is crucial to not only the health of aquatic environments, but to humans as well. Chemicals that possess the ability to persist in the environment or that have the potential to bioaccumulate, pose a greater risk to organisms that are exposed to these chemicals. The Organization for Economic Cooperation and Development Guideline 305 outlines… more
Date: December 2013
Creator: Cantu, Mark
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Cytochrome P450 Gene Expression Modulates Anoxia Sensitivity in Caenorhabditis Elegans

Description: With an increasing population suffering from obesity or Diabetes Mellitus (DM), it is more pertinent than ever to understand how physiological changes impact cellular processes. Patients with DM often suffer from obesity, hyperglycemia, altered fatty acids that contribute to vascular dysfunction, and increased risk to ischemia. Caenorhabditis elegans is a model system used to study the conserved insulin signaling pathway, cellular responses in whole organisms and the impact a glucose diet has o… more
Date: August 2016
Creator: Quan, Daniel L
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Immunohistochemistry of the Gills of the Channel Catfish Ictalurus Punctatus: Cells and Neurochemicals That May Be Involved in the Control of Cardioventilatory Reflexes

Description: In teleost fishes the neurochemicals involved in sensing and responding to hypoxia are unresolved. Serotonergic branchial neuroepithelial cells (NECs) are putative O2 chemoreceptors believed to be homologous to the neural crest (NC) derived APUD (amine-precursor uptake and decarboxylation) pulmonary NECs and carotid body type-1 glomus cells. Branchial NECs contain serotonin (5-HT), thought to be central to the induction of the hypoxic cardioventilatory reflexes. However, application of 5-HT … more
Date: December 2013
Creator: Oden, David S.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

The Effects of Glyphosate Based Herbicides on Chick Embryo Development

Description: Glyphosate based herbicides are among the most widely used herbicides in the world. The purpose of this study was to determine developmental toxicity of glyphosate, the active ingredient in the common herbicide Roundup, on developing chicken embryos. Few studies have examined toxic effects of glyphosate alone versus the full compound formulations of Roundup, which include adjuvants and surfactants. Adjutants and surfactants are added to aid in solubility and absorption of glyphosate. In thi… more
Date: August 2013
Creator: Winnick, Blake Edward
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Identification of the Neurobiological Basis of Hemodynamic Responses Correlated with Cognitive Stroop Task Performance After an Acute Bout of Aerobic Exercise

Description: Cardiovascular activities may increase the brain blood flow improving neuronal activities leading to improved cognition. Consequently, the effects of an acute bout of moderate intensity aerobic exercise on brain hemodynamics and its correlation with cognitive color-word Stroop task performance were tested. The Stroop tasks were congruent (color matches word) and incongruent (color does not match word). Prefrontal (PFC) and motor cortex (MC) blood flow was recorded by fNIRS (functional near-infr… more
Date: May 2018
Creator: Pal, Amrita
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries

Impact of Anti-S2 Peptides on a Variety of Muscle Myosin S2 Isoforms and Hypertrophic Cardiomyopathy Mutants Revealed by Fluorescence Resonance Energy Transfer and Gravitational Force Spectroscopy

Description: Myosin subfragment-2 (S2) is an intrinsically unstable coiled coil. This dissertation tests if the mechanical stability of myosin S2 would influence the availability of myosin S1 heads to actin thin filaments. The elevated instability in myosin S2 coiled coil could be one of the causes for hypercontractility in Familial Hypertrophic Cardiomyopathy (FHC). As hypothesized FHC mutations, namely E924K and E930del, in myosin S2 displayed an unstable myosin S2 coiled coil compared to wild type as mea… more
Date: August 2020
Creator: Aboonasrshiraz, Negar
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Glucose-Induced Developmental Delay is Modulated by Insulin Signaling and Exacerbated in Subsequent Glucose-Fed Generations in Caenorhabditis elegans

Description: In this study, we have used genetic, cell biological and transcriptomic methods in the nematode C. elegans as a model to examine the impact of glucose supplementation during development. We show that a glucose-supplemented diet slows the rate of developmental progression (termed "glucose-induced developmental delay" or GIDD) and induces the mitochondrial unfolded protein response (UPRmt) in wild-type animals. Mutation in the insulin receptor daf-2 confers resistance to GIDD and UPRmt in a daf-1… more
Date: December 2023
Creator: Nahar, Saifun
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Effect of the Resistance Exercise-Induced Hormonal Changes on Satellite Cell Myogenic State

Description: Skeletal muscle satellite cells are important for muscle repairing and muscle mass growth. For a successful muscle regenerative process, satellite cells have to sequentially undergoing different stages of myogenic process, i.e. proliferative state and differentiation state. To support this process, the presence of different circulating factors, such as immune cells, cytokines, and hormones, at the appropriate time course is critical. Among these factors, hormones, such as testosterone, cortisol… more
Date: May 2018
Creator: Luk, Hui Ying
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Endocrine Disruption of Levonorgestrel in Early-life Stages of Fathead Minnows, Pimephales Promelas

Description: Pharmaceuticals have routinely been detected in the environment resulting in a growing concern about whether these drugs could elicit effects on aquatic organisms. The concerns are centered on the highly conserved nature of mammalian therapeutic targets in fish. These pharmaceuticals are found at very low levels in the environment, which can result in sub-lethal effects in aquatic organisms. Therefore, 28 d early-life stage studies were conducted on six pharmaceuticals to assess their impact… more
Date: August 2013
Creator: Overturf, Matthew D.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

CO2 Transport and Acid-Base Status during Fluctuations in Metabolic Status in Reptiles

Description: Reptiles can often experience perturbations that greatly influence their metabolic status (e.g., temperature, exercise, digestion, and ontogeny). The most common cause of fluctuations in metabolic status in post-embryonic reptiles is arguably digestion and physical activity (which will be further referred to as exercise). The objective of this thesis is to determine the mechanisms involved in CO2 transport during digestion, determine the mechanisms that allow for the maintenance of acid-base ho… more
Date: December 2021
Creator: Conner, Justin Lawrence
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries

Ceramide Biosynthesis and NEET Proteins Impact Development, Function, and Maintenance of the Caenorhabditis elegans Germline

Description: I used the C. elegans genetic model to examine the role of ceramide biosynthesis (sphingolipid pathway) and iron regulation and found that each process impacts germline development and function. Using a sphingolipid specific antibody mAb15B4, I found that sphingolipids are associated with germ granules (P granules) within C. elegans and zebrafish; thus, suggesting conservation of macromolecules associated with germ granules. Phenotype analysis of ceramide biosynthesis mutants in C. elegans reve… more
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Date: August 2019
Creator: King, Skylar Dawn
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries

Benefits of Probiotics on Mortality, Growth Performance, Physiological Condition and Gut Histomophology of Juvenile Red Drum (Sciaenops ocellatus)

Description: Results from the present study found for the first time that the use of bacterial strains of Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium thermophilum, and Enterococcus faecium from the commercial product PrimaLac® had the potential to act as a possible probiotic for juvenile red drum. The addition of PrimaLac® probiotics [whether as a water-soluble probiotic (WSP) or in a probiotic enhanced starter feed (PESF)] reduced mortality (%M), enhanced growth rates (MW, LT, SGR, and … more
Date: May 2021
Creator: Busby, Wren Adell
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries

The Effect of Developmental Hypoxia on Cardiac Physiology in Three Species: Alligator mississippiensis, Chelydra serpentina, and Danio rerio

Description: In this dissertation, I explored the effects of developmental hypoxia on heart contractility in three separate species of ectotherms: the common snapping turtle (Chelydra serpentina), the American alligator (Alligator mississippiensis), and the zebrafish (Danio rerio). I began with the common snapping turtle and tested whether the utilization of the sarcoplasmic reticulum was altered in response to developmental hypoxia. In the next two chapters, developmental hypoxia of the American alligator … more
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Date: December 2023
Creator: Smith, Brandt Ragan
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Exposure to Nanomaterials Results in Alterations of Inflammatory and Atherosclerotic Signaling Pathways in the Coronary Vasculature of Wildtype Rodents

Description: Cardiovascular disease (CVD) is the leading cause of death for people of most ethnicities on a global scale, and countless research efforts on the pathology of CVD has been well-characterized over the years. However, advancement in modern technologies, such as nanotechnology, has generated environmental and occupational health concerns within the scientific community. Current investigation of nanotoxicity calls into question the negative effects nanomaterials may invoke from their environmental… more
Date: August 2018
Creator: Davis, Griffith M.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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