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Age, sex and other factors in radiation carcinogenesis

Description: It has been held for a long time that the young are more susceptible than adults to the induction of cancer by radiation. The data in support of that contention are accumulating especially from human studies. In an exposed population a significant fraction of the total population risk may be attributed to the risk associated with those who were young at the time of exposure. Since cancer may not appear for decades after exposure estimates of risk may require models for projecting the lifetime r… more
Date: January 1, 1988
Creator: Fry, R. J. M. & Carnes, B. A.
Partner: UNT Libraries Government Documents Department
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Studies of acute and chronic radiation injury at the Biological and Medical Research Division, Argonne National Laboratory, 1953-1970: Description of individual studies, data files, codes, and summaries of significant findings

Description: Between 1953 and 1970, studies on the long-term effects of external x-ray and {gamma} irradiation on inbred and hybrid mouse stocks were carried out at the Biological and Medical Research Division, Argonne National Laboratory. The results of these studies, plus the mating, litter, and pre-experimental stock records, were routinely coded on IBM cards for statistical analysis and record maintenance. Also retained were the survival data from studies performed in the period 1943-1953 at the Nationa… more
Date: May 1, 1994
Creator: Grahn, D.; Fox, C.; Wright, B. J. & Carnes, B. A.
Partner: UNT Libraries Government Documents Department
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Chemoprevention by WR-2721

Description: WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid] is an effective chemopreventive agent. C57BL [times] BALB/c F[sub 1] female mice, were exposed to a single whole-body dose of 206 cGy from a [sup 60]Co photon source. Those groups treated with VATR-2721 (400 mg/kg) were administered the agent i.p. 30 min prior to irradiation. Over 90% of deaths were determined to be due to tumor involvement. WR-2721 afforded significant protection against life shortening due to radiation-induced tumors… more
Date: January 1, 1993
Creator: Grdina, D. J. & Carnes, B. A.
Partner: UNT Libraries Government Documents Department
open access

Chemoprevention by WR-2721

Description: WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid] is an effective chemopreventive agent. C57BL {times} BALB/c F{sub 1} female mice, were exposed to a single whole-body dose of 206 cGy from a {sup 60}Co photon source. Those groups treated with VATR-2721 (400 mg/kg) were administered the agent i.p. 30 min prior to irradiation. Over 90% of deaths were determined to be due to tumor involvement. WR-2721 afforded significant protection against life shortening due to radiation-induced tumors… more
Date: May 1, 1993
Creator: Grdina, D. J. & Carnes, B. A.
Partner: UNT Libraries Government Documents Department
open access

Studies of acute and chronic radiation injury at the Biological and Medical Research Division, Argonne National Laboratory, 1970-1992: The JANUS Program Survival and Pathology Data

Description: A research reactor for exclusive use in experimental radiobiology was designed and built at Argonne National Laboratory in the 1960`s. It was located in a special addition to Building 202, which housed the Division of Biological and Medical Research. Its location assured easy access for all users to the animal facilities, and it was also near the existing gamma-irradiation facilities. The water-cooled, heterogeneous 200-kW(th) reactor, named JANUS, became the focal point for a range of radiobio… more
Date: February 1995
Creator: Grahn, D.; Wright, B. J.; Carnes, B. A.; Williamson, F. S. & Fox, C.
Partner: UNT Libraries Government Documents Department
open access

Studies of Acute and Chronic Radiation Injury at the Biological and Medical Research Division, Argonne National Laboratory, 1970-1992 : the JANUS Program Survival and Pathology Data

Description: A research reactor for exclusive use in experimental radiobiology was designed and built at Argonne National Laboratory in the 1960`s. It was located in a special addition to Building 202, which housed the Division of Biological and Medical Research. Its location assured easy access for all users to the animal facilities, and it was also near the existing gamma-irradiation facilities. The water-cooled, heterogeneous 200-kW(th) reactor, named JANUS, became the focal point for a range of radiobio… more
Date: February 1995
Creator: Grahn, D.; Wright, B. J.; Carnes, B. A.; Williamson, F. S. & Fox, C.
Partner: UNT Libraries Government Documents Department
open access

Protection by WR-151327 against late-effect damage from fission-spectrum neutrons

Description: Considerable effort has been expended to develop chemical agents capable of modifying radiation-induced damage to biological systems. The authors describe here differences in the radioprotective effect of WR-151327, depending on the sex of the animal and the post-irradiation time interval considered. The greatest effect in female animals is prior to 805 days post irradiation. The greater protection in male animals is seen during the time increment following 850 days after irradiation. While it … more
Date: January 1, 1990
Creator: Grdina, D. J. (Argonne National Lab., IL (USA) Chicago Univ., IL (USA). Dept. of Radiation and Cellular Oncology); Wright, B. J. & Carnes, B. A. (Argonne National Lab., IL (USA))
Partner: UNT Libraries Government Documents Department
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