DNA-Nuclear Matrix Interactions and Ionizing Radiation Sensitivity
Description:
The association between inherent ionizing radiation sensitivity and DNA supercoil unwinding in mammalian cells suggests that the DNA-nuclear matrix attachment region (MAR) plays an important role in radiation response. In radioresistant cells, the MAR structure may exist in a more stable, open configuration, limiting DNA unwinding following strand break induction and maintaining DNA ends in close proximity for more rapid and accurate rejoining. In addition, the open configuration at these matri…
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Date:
March 1, 1993
Creator:
Schwartz, Jeffrey L. & Vaughan, Andrew T. M.
Item Type:
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Partner:
UNT Libraries Government Documents Department