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Trends in Magnesium Intake among Hispanic Adults, the National Health and Nutrition Examination Survey (NHANES) 1999-2014

Description: Paper describes the results of a study examining magnesium intake in Hispanic adults, using data from the NHANES from 1999-2014, stratified by gender, Hispanic origins, age, and poverty income ratio (PIR) level.
Date: November 22, 2019
Creator: Liu, Jialiang; Huang, Yuhan; Dai, Qi; Fulda, Kimberly G.; Chen, Shande & Tao, Meng-Hua
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Partner: UNT Health Science Center
open access

A Novel Prodrug Approach for Central Nervous System-Selective Estrogen Therapy

Description: This article gives an overview of the discovery of small-molecule bioprecursor prodrugs carrying the para-quinol scaffold on the steroidal A-ring that are preferentially metabolized in the CNS to the corresponding estrogens. Selected examples are shown to illustrate that, independently of the route of administrations and duration of treatments, these agents produce high concentration of estrogens only in the CNS without peripheral hormonal liability. 10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)… more
Date: November 19, 2019
Creator: Prokai-Tatrai, Katalin & Prókai, László, 1958-
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Partner: UNT Health Science Center
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Biodiversity of protists and nematodes in the wild nonhuman primate gut

Description: Article describes study which used an 18S rRNA gene fragment metabarcoding approach to assess the eukaryotic assemblage of 62 individuals representing 16 nonhuman primate NHP species to better understand the factors that influence the assembly and diversity of gut-associated eukaryotes.
Date: November 12, 2019
Creator: Mann, Allison E.; Mazel, Florent; Lemay, Matthew A.; Morien, Evan; Billy, Vincent; Kowalewski, Martin et al.
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Partner: UNT Health Science Center
open access

“Youth Are More Aware and Intelligent than Imagined”: The Mountain Air Youth Photovoice Project

Description: This article looks at respiratory illness in Appalachian Kentucky because it reports some of the highest rates of respiratory illness in the United States. As part of the Mountain Air Project, local youth were invited to share their perspectives on possible contributing factors to respiratory illness, and the authors undertook an exploratory study to determine the utility of photovoice to elicit such perspectives with this population. This study demonstrates the value of incorporating youth per… more
Date: October 11, 2019
Creator: Cardarelli, Katheryn M.; Paul, Marcy; May, Beverly; Dunfee, Madeline; Browning, Steven & Schoenberg, Nancy
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Partner: UNT Health Science Center
open access

Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach

Description: Using thyrotropin-releasing hormone (TRH) as a model, paper explores whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide.
Date: July 18, 2019
Creator: Prokai-Tatrai, Katalin; De La Cruz, Daniel L.; Nguyen, Vien; Ross, Benjamin P.; Toth, Istvan & Prókai, László, 1958-
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Partner: UNT Health Science Center
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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

Description: The article is part of a series of Editorials published biannually that highlights a number of recently published articles that describe crucial findings.
Date: June 30, 2019
Creator: Mangoni, Arduino A; Vanden Eynde, Jean Jacques; Jampilek, Josef; Hadjipavlou-Litina, Dimitra; Liu, Hong; Reynisson, Jóhannes et al.
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Partner: UNT Health Science Center
open access

Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

Description: This article is an overview the interplay between HIV-1 viral and cellular proteins for restrictions/competitions for proliferation of the virus in the infected cell, which could open a new avenue for the development of therapeutics against HIV-1 via targeting a specific step of the proteasome degradation pathway during the HIV-1 life cycle.
Date: June 19, 2019
Creator: Rojas, Vivian K. & Park, In-Woo
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Partner: UNT Health Science Center
open access

Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors

Description: Study describes the use of a non-cytotoxic dose of histone deacetylase (HDAC) inhibitors to induce pulmonary carcinoid somatostatin receptor subtype 2 (SSTR2) expression to diagnose pulmonary carcinoids.
Date: June 3, 2019
Creator: Guenter, Rachael E.; Aweda, Tolulope; Matos, Danilea M. Carmona; Whitt, Jason; Chang, Alexander W.; Cheng, Eric Y. et al.
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Partner: UNT Health Science Center
open access

Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract

Description: The article describes a study that tested and confirmed the hypothesis that TRPA1 expressed in the primary sensory afferents may modulate the function of second order NTS neurons. The expression of TRPA1 was detected in presynaptic locations, but not the somata of caudal NTS neurons that did not express TRPA1 mRNA or proteins. Moreover, caudal NTS neurons did not show somatodendritic responsiveness to TRPA1 agonists, while TRPA1 immunostaining was detected only in the afferent fibers.
Date: April 26, 2019
Creator: Feng, Lin; Uteshev, Victor V. & Premkumar, Louis S.
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Partner: UNT Health Science Center
open access

The Enigmatic Protein Kinase C-eta

Description: The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death.
Date: February 13, 2019
Creator: Basu, Alakananda
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Partner: UNT Health Science Center
open access

Treatment and Prevention of Recurrent Clostridium difficile Infection with Functionalized Bovine Antibody-Enriched Whey in a Hamster Primary Infection Model

Description: This article focuses on the development of an alternative drug for the treatment of Clostridium difficile infection (CDI). Oral administration of anti-CD-WPI is a functional therapy of CDI in infected hamsters for both primary treatment and prevention of recurrence. Thus, anti-CD-WPI could address the urgent unmet medical need for treating and preventing recurrent CDI in humans.
Date: February 6, 2019
Creator: Heidebrecht, Hans-Jürgen; Weiss, William J.; Pulse, Mark; Lange, Anton; Gisch, Karina; Kliem, Heike et al.
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Partner: UNT Health Science Center
open access

Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress

Description: This article investigates if chronic inhibition of DLDH could also attenuate oxidative stress in type 2 diabetes. It is the authors' belief that DLDH inhibition could be a novel approach to fighting type 2 diabetes.
Date: February 2, 2019
Creator: Yang, Xiaojuan; Song, Jing & Yan, Liang-Jun
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Partner: UNT Health Science Center
open access

Adherence to Exercise Programs in Older Adults: Informative Report

Description: This article focuses on filling information gaps regarding adherence to physical activity and exercise in the health care spectrum of older adults (OA) and an overview of the benefits of physical activity for OA. Exercise adherence in OA is a multifactorial problem encompassing many biopsychosocial factors. Factors affecting adherence in the OA include socioeconomic status, education level, living arrangements, health status, pacemakers, physical fitness, and depression. Improving adherence cou… more
Date: January 22, 2019
Creator: Rivera-Torres, Solymar; Fahey, Thomas D. & Rivera, Miguel A.
Item Type: Refine your search to only Article
Partner: UNT Health Science Center
open access

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-4

Description: The article is part of a series of Editorials published biannually that highlights a number of recently published articles that describe crucial findings. This article highlights 25 different articles that range from asthma treatment to new oral β-lactamase inhibitor (BLI).
Date: December 31, 2018
Creator: Mangoni, Arduino A; Guillou, Catherine; Vanden Eynde, Jean Jacques; Hulme, Christopher; Jampilek, Josef; Li, Wei et al.
Item Type: Refine your search to only Article
Partner: UNT Health Science Center
open access

Aircraft-Assisted Pilot Suicides in the General Aviation Increased for One-Year Period after 11 September 2001 Attack in the United States

Description: The article describes a study that evaluated the possible effect the 11 September 2001, terrorist attacks had on pilot AASs in the U.S. Fatal aviation accidents in the National Transportation Safety Board (NTSB) database were searched using the following search words: “suicide”, “murder-suicide” and “homicide-suicide”. The timeline between 11 September 1996, and 11 September 2004, was analyzed. This study showed an association, albeit not determinate causal effect, of a very specific series of … more
Date: November 12, 2018
Creator: Vuorio, Alpo; Laukkala, Tanja; Junttila, Ilkka; Bor, Robert; Budowle, Bruce; Pukkala, Eero et al.
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Partner: UNT Health Science Center
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Sarcoidosis and Its Splenic Wonder: A Rare Case of Isolated Splenic Sarcoidosis

Description: This article is a case study discussing a case of a 40-year-old female with isolated splenic sarcoidosis found to have isolated splenomegaly with multiple hypodense splenic lesions and no other multisystem involvement. Isolated splenomegaly is very rare and an uncommon presentation of sarcoidosis. This case is clinically challenging because of the extensive differential diagnosis. The authors conclude that sarcoidosis of the spleen, although rare, should be considered in the differential diagno… more
Date: November 5, 2018
Creator: Jhaveri, Khushali & Surani, Salim R.
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Partner: UNT Health Science Center
open access

Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research

Description: This review aims to find effective phytoconstituents in cataract treatments in vitro, ex vivo, and in vivo. Scientists have focused their attention not only for anti-cataract activity in vitro, but also in ex vivo and in vivo from the review of active phytoconstituents in medicinal plants. In our present review, we identified 58 active phytoconstituents with strong anti-cataract effects at in vitro and ex vivo with lack of in vivo studies.
Date: October 26, 2018
Creator: Lim, Vuanghao; Schneider, Edward; Wu, Hongli & Pang, Iok-Hou
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Partner: UNT Health Science Center
open access

Lipopolysaccharide Challenge Reveals Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Murine Systemic Lupus Erythematosus

Description: Study explores whether chronic inflammatory processes in systemic lupus erythematosus (SLE) are in part due to hypothalamic-pituitary-adrenal (HPA) axis dysfunction by challenging female control and SLE mice with lipopolysaccharide (LPS) and measuring c-Fos expression as an index of neuronal activation, plasma adrenocorticotrophic hormone (ACTH) as an index of anterior pituitary function, and plasma corticosterone as an index of adrenal function.
Date: October 4, 2018
Creator: Pham, Grace S. & Mathis, Keisa W.
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Partner: UNT Health Science Center
open access

Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway

Description: This article highlights a study aimed to investigate neuroprotective mechanisms of HN. We analyzed intracellular Ca²+ levels, reactive oxygen species (ROS) production, and the MAPKs signal transduction cascade using an in vitro NMDA-mediated excitotoxicity of cortical neurons model.
Date: September 29, 2018
Creator: Yang, Xiaorong; Zhang, Hongmei; Wu, Jinzi; Yin, Litian; Yan, Liang-Jun & Zhang, Ce
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Partner: UNT Health Science Center
open access

Food Choice Priorities Change Over Time and Predict Dietary Intake at the End of the First Year of College Among Students in the U.S.

Description: Study assesses food choice priorities (FCP) and associations with consumption of fruits and vegetables (FV), fiber, added sugars from non-beverage sources, and sugar-sweetened beverages (SSB) among college students, and how those choices evolve over their first year of college.
Date: September 13, 2018
Creator: Vilaro, Melissa J.; Colby, Sarah E.; Riggsbee, Kristin; Zhou, Wenjun; Byrd-Bredbenner, Carol; Olfert, Melissa D. et al.
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Partner: UNT Health Science Center
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