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open access

17β-Estradiol Delivered in Eye Drops: Evidence of Impact on Protein Networks and Associated Biological Processes in the Rat Retina through Quantitative Proteomics

Description: Study analyzes target engagements through the identification of functional protein networks impacted after delivery of 17β-estradiol in eye drops to facilitate the development of broad-spectrum retina neuroprotectants that can be delivered through topical dosage forms.
Date: January 27, 2020
Creator: Prókai, László, 1958-; Zaman, Khadiza; Nguyen, Vien & Prokai-Tatrai, Katalin
open access

Adherence to Exercise Programs in Older Adults: Informative Report

Description: This article focuses on filling information gaps regarding adherence to physical activity and exercise in the health care spectrum of older adults (OA) and an overview of the benefits of physical activity for OA. Exercise adherence in OA is a multifactorial problem encompassing many biopsychosocial factors. Factors affecting adherence in the OA include socioeconomic status, education level, living arrangements, health status, pacemakers, physical fitness, and depression. Improving adherence cou… more
Date: January 22, 2019
Creator: Rivera-Torres, Solymar; Fahey, Thomas D. & Rivera, Miguel A.
open access

Aircraft-Assisted Pilot Suicides in the General Aviation Increased for One-Year Period after 11 September 2001 Attack in the United States

Description: The article describes a study that evaluated the possible effect the 11 September 2001, terrorist attacks had on pilot AASs in the U.S. Fatal aviation accidents in the National Transportation Safety Board (NTSB) database were searched using the following search words: “suicide”, “murder-suicide” and “homicide-suicide”. The timeline between 11 September 1996, and 11 September 2004, was analyzed. This study showed an association, albeit not determinate causal effect, of a very specific series of … more
Date: November 12, 2018
Creator: Vuorio, Alpo; Laukkala, Tanja; Junttila, Ilkka; Bor, Robert; Budowle, Bruce; Pukkala, Eero et al.
open access

Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms

Description: This review attempts to provide integrated information at the levels of oxidative signaling mechanisms by which ethanol withdrawal (EW) provokes brain injuries and 17β-estradiol (E2) protects against it. Unmanaged sudden withdrawal from the excessive consumption of alcohol (ethanol) adversely alters neuronal integrity in vulnerable brain regions such as the cerebellum, hippocampus, or cortex.
Date: July 20, 2010
Creator: Jung, Marianna E. & Metzger, Daniel B.
open access

Association of Home Food Availability with Prediabetes and Diabetes among Adults in the United States

Description: This article examined associations of home food availabilities with prediabetes and diabetes among 8929 adults (20–70 years) participating in 2007–2010 National Health and Nutrition Examination Surveys. The results show prediabetes participants had lower availability of healthy foods and higher availability of unhealthy foods, suggesting the need to improve healthy food availability at home for this population.
Date: April 25, 2020
Creator: McAtee, Jenniffer; Tao, Meng-Hua; King, Christian & Chai, Weiwen
open access

Barriers for pregnant women living in rural, agricultural villages to accessing antenatal care in Cambodia: A community-based cross-sectional study combined with a geographic information system

Description: Article describes how morbidity and mortality is still a major public health issue in low- and middle-income countries such as Cambodia. This study examines the barriers for pregnant women living in rural, agricultural villages.
Date: March 19, 2018
Creator: Yasuoka, Junko; Nanishi, Keiko; Kikuchi, Kimiyo; Suzuki, Sumihiro; Ly, Po; Thavrin, Boukheng et al.
open access

Biodiversity of protists and nematodes in the wild nonhuman primate gut

Description: Article describes study which used an 18S rRNA gene fragment metabarcoding approach to assess the eukaryotic assemblage of 62 individuals representing 16 nonhuman primate NHP species to better understand the factors that influence the assembly and diversity of gut-associated eukaryotes.
Date: November 12, 2019
Creator: Mann, Allison E.; Mazel, Florent; Lemay, Matthew A.; Morien, Evan; Billy, Vincent; Kowalewski, Martin et al.
open access

Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach

Description: Using thyrotropin-releasing hormone (TRH) as a model, paper explores whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide.
Date: July 18, 2019
Creator: Prokai-Tatrai, Katalin; De La Cruz, Daniel L.; Nguyen, Vien; Ross, Benjamin P.; Toth, Istvan & Prókai, László, 1958-
open access

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-4

Description: The article is part of a series of Editorials published biannually that highlights a number of recently published articles that describe crucial findings. This article highlights 25 different articles that range from asthma treatment to new oral β-lactamase inhibitor (BLI).
Date: December 31, 2018
Creator: Mangoni, Arduino A; Guillou, Catherine; Vanden Eynde, Jean Jacques; Hulme, Christopher; Jampilek, Josef; Li, Wei et al.
open access

Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research

Description: This review aims to find effective phytoconstituents in cataract treatments in vitro, ex vivo, and in vivo. Scientists have focused their attention not only for anti-cataract activity in vitro, but also in ex vivo and in vivo from the review of active phytoconstituents in medicinal plants. In our present review, we identified 58 active phytoconstituents with strong anti-cataract effects at in vitro and ex vivo with lack of in vivo studies.
Date: October 26, 2018
Creator: Lim, Vuanghao; Schneider, Edward; Wu, Hongli & Pang, Iok-Hou
open access

Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody

Description: This article examines the feasibility of encapsulating monoclonal antibodies within poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a water/oil/water double emulsion solvent evaporation technique. This method can be used to prepare protective polymeric nanoparticles for transporting functional antibodies to the cytoplasmic compartment of cancer cells. The author's studies achieved successful formulation of antibody loaded polymeric nanoparticles, thus indicating that a PLGA-based antib… more
Date: February 12, 2015
Creator: Gdowski, Andrew; Ranjan, Amalendu; Mukerjee, Anindita & Vishwanatha, Jamboor
open access

Direct Analysis in Real Time (DART) of an Organothiophosphate at Ultrahigh Resolution by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry

Description: Paper describes results of an analysis of the organothiophosphate malathion using DART-Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry (MS) and tandem mass spectrometry (MS/MS).
Date: January 16, 2016
Creator: Prókai, László, 1958- & Stevens, Stanley M.
open access

The Enigmatic Protein Kinase C-eta

Description: The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death.
Date: February 13, 2019
Creator: Basu, Alakananda
open access

Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract

Description: The article describes a study that tested and confirmed the hypothesis that TRPA1 expressed in the primary sensory afferents may modulate the function of second order NTS neurons. The expression of TRPA1 was detected in presynaptic locations, but not the somata of caudal NTS neurons that did not express TRPA1 mRNA or proteins. Moreover, caudal NTS neurons did not show somatodendritic responsiveness to TRPA1 agonists, while TRPA1 immunostaining was detected only in the afferent fibers.
Date: April 26, 2019
Creator: Feng, Lin; Uteshev, Victor V. & Premkumar, Louis S.
open access

Flanking Variation Influences Rates of Stutter in Simple Repeats

Description: This article shows that rates of stutter can vary substantially depending on the flanking haplotype, and while there are cases where the LUS is a better predictor of stutter than the PAL, examples to the contrary are apparent in commonly assayed forensic markers. Further, flanking variation that is 7 bp from the repeat region can impact rates of stutter. These findings suggest that non-proximal effects, such as DNA secondary structure, may be impacting the rates of stutter in common forensic sh… more
Date: November 17, 2017
Creator: Woerner, August E.; King, Jonathan L. & Budowle, Bruce
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