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The Preparation and Properties of Mammalian Ribonucleic Acids

Description: "A method for the preparation of mammalian ribonucleic acids employing high concentrations of guanidine hydrochloride in the fractionation procedure is reported in this paper. Aside from the facility of preparation the method has the advantage of avoiding conditions of acidity and alkalinity which might degrade tissue ribonucleic acids and, by virtue of the protein denaturant action of guanidine salts, of minimizing the possibility for enzymatic degradation" (p. 3).
Date: October 12, 1950
Creator: Volkin, E. & Carter, C. E.