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Effects of an exogenous ketone ester using multi-omics in skeletal muscle of aging C57BL/6J male mice

Description: Article shows that oral R,S-1,3, butanediol diacetoacetate (BD-AcAc2) consumption results in body weight loss or maintenance with moderate increases in circulating ketones. The purpose of this study was to determine if a diet consisting of 25% BD-AcAc2 (ketone ester, KE) would alter body composition, transcriptional regulation, the proteome, and the lipidome of skeletal muscle in aged mice.
Date: November 15, 2022
Creator: Roberts, Brandon M.; Deemer, Sarah E.; Smith Jr., Daniel L.; Mobley, James A.; Musi, Nicolas & Plaisance, Eric P.
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open access

Dynamic cerebral autoregulation is intact in chronic kidney disease

Description: Article describes how chronic kidney disease patients experience an elevated risk for cerebrovascular disease, and a factor that may contribute to this is an impairment in dynamic cerebral autoregulation. The authors test their hypothesis by comparing dynamic cerebral autoregulation between CKD patients stages III-IV and matched controls (CON) without CKD.
Date: November 2, 2022
Creator: Sprick, Justin D.; Jones, Toure; Jeong, Jinhee; DaCosta, Dana & Park, Jeanie
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