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Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4
This article describes findings that demonstrate the affect of diosgenin (DG) on inhibiting the resilient breast cancer stem cells (CSCs) which could provide a benchmark for the development of DG-based therapies in breast cancer treatment.
Social Reward Questionaire--Adolescent Version and its association with callous-unemotional traits
This article describes a study in which the adult Social Reward Questionnaire is adapted for use with adolescents.
Novel transcriptome assembly and comparative toxicity pathway analysis in mahi-mahi (Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil
This article establishes the de novo transcriptomic database from the embryos and larvae of mahi-mahi exposed to water accommodated fractions (HEWAFs) of two Deepwater Horizon oil types (weathered and source oil) in an effort to advance understanding of the molecular aspects involved during specific toxicity responses.
Adsorption and molecular siting of CO₂, water, and other gases in the superhydrophobic, flexible pores of FMOF-1 from experiment and simulation
This article discusses the use of neutron diffraction and molecular simulations to investigate the framework expansion behaviour and the accessibility of the small pockets to N₂, O₂, and CO₂.
Phase Transition Enthalpy Measurements of Organic and Organometallic Compounds and Ionic Liquids. Sublimation, Vaporization and Fusion Enthalpies From 1880 to 2015. Part 2. C11-C192.
This article updates the second part of a compendium of phase change enthalpies published in 2010 to include the period 1880-2015.
Redox non-innoence permits catalytic nitrene carbonylation by (dadi)Ti=NAd (Ad = adamantyl)
This article describes (dadi)Ti(X/L) species that manifest redox non-innocence (RNI), including a rare instance in which carbon monoxide does not affect redox activity at the metal, and does not bind, thus permitting its use as a substrate in catalysis.
Non-invasive Measures of Core Temperature versus Ingestible Thermistor during Exercise in the Heat
This article discusses a study to cross-validate temporal, two tympanic devices, and oral devices compared to an ingestible thermistor during exercise in a hot, humid environment.
Pharmaceuticals Solubility is Still Nowadays Widely Studied Everywhere
This editorial discusses the importance of equilibrium solubility in pharmaceutical areas.
Computational Identification of Amino-Acid Mutations that Further Improve the Activity of a Chalcone-Flavonone Isomerase from Glycine max
This article discusses a computational approach that combines multiple sequence alignment, positive selection detection, and molecular docking to identify and design beneficial amino-acid mutations that further improve the intramolecular-cyclization activity of a chalcone-flavonone isomerase from Glycine max (GmCHI).
Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates
This article describes the use of three members of the human NEET protein family (CISD1, mitoNEET; CISD2, NAF-1 or Miner 1; and CISD3, Miner2) as guides to conduct a phylogenetic analysis of eukaryotic NEET proteins and their evolution.
A new, faint population of X-ray transients
This article reports on the detection of a remarkable new fast high-energy transient found in the Chandra Deep Field-South, robustly associated with a faint host in the CANDELS survey.
The Mechanisms and Biomedical Applications of an NIR BODIPY-Based Switchable Fluorescent Probe
This article investigates the switching mechanism of a recently reported near-infrared environment-sensitive fluorophore, ADP(CA)₂.
Commentary on "Effect of β-alanine and the solvent composition on the solubility of solvate of calcium D-pantothenate containing four molecules of methanol and one molecule of water (D-PC·4MeOH·1H₂O)"
This article points out problems associated with two of the mathematical treatments used by authors Han et al. (2017) for the solubility behavior of calcium D-panthenate solvate as the mole fraction concentration β-alanine approaches zero.
Lophozonia tree cavities used for nesting by Slender-billed Parakeets (Enicognathus leptorhynchus) in the central valley of southern Chile: a potentially vanishing keystone resource
This article describes and quantifies characteristics of southern beech (Lophoonia obliqua) trees and their associated cavities used for nesting by Slender-billed Parakeets in the central valley of southern Chile.
A Dual-Modality System for Both Multi-Color Ultrasound-Switchable Fluorescence and Ultrasound Imaging
This article discusses the development of a dual-modality imaging system by combining recently developed ultrasound-switchable fluorescence (USF) imaging technology with the conventional ultrasound (US) B-mode imaging.
ALMA Observations Show Major Mergers Among the Host Galaxies of Fast-growing, High-redshift, Supermassive Black Holes
This article presents new ALMA band-7 data for a sample of six luminous quasars at z ≃ 4.8, powered by fast-growing supermassive black holes (SMBHs) with rather uniform properties.
Commentary on "Thermodynamic equilibrium of hydroxyacetic acid in pure and binary solvent systems"
This article discusses published mathematical representations by Huant et al. (2017) for describing how the measured mole fraction solubility varies with solvent composition in the binary (ethanol + ethyl acetate) and binary (acetone + ethanol) solvent systems.
Bold-Independent Computational Entropy Assesses Functional Donut-Like Structures in Brain fMRI Images
This article introduces a novel technique of fMRI images analysis, called computational proximity method, i.e., nucleus clustering in Voronoï tessellations.
Wnt signaling in triple-negative breast cancer
This review summarizes the involvement of dysregulated Wnt signaling in the progression of triple-negative breast cancer (TNBC) and TNBC stem cells, as well as the emerging therapies that are currently under investigation.
A chemical genetic screen uncovers a small molecule enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in Arabidopsis
This article demonstrates the feasibility of using an unbiased chemical genetic approach to identify new pharmacological tools for manipulating FAAH- and NAE-mediated physiological processes in plants.
Commentary on "Solubility and solution thermodynamics of cetilistat in water and (acetone, isopropyl alcohol, acetonitrile) binary solvent mixtures"
This article reanalyzes experimental solubility data reported in the recent paper "Solubility and solution thermodynamics of cetilistat in water and (acetone, isopropyl alcohol, acetonitrile) binary solvent mixtures" in the Journal of Molecular Liquids.
Solubility and preferential solvation of some n-alkyl-parabens in methanol + water mixtures at 298.15 K
This article describes methyl, ethyl and propyl parabens equilibrium solubility as determined in (methanol + water) binary mixtures at 298.15 K.
Study of traits and recalcitrance reduction of field-grown COMT down-regulated switchgrass
This article discusses the fundamental features of why biomass is recalcitrant to conversion without pretreatment.
A Symmetric Approach Elucidates Multisensory Information Integration
This article shows that the Borsuk-Ulam theorem applies also to multisensory integration: two environmental stimuli from different sensory modalities display similar features when mapped into cortical neurons.
Enthalpies of solution and enthalpies of solvation of organic solutes in ethylene glycol at 298.15 K: prediction and analysis of intermolecular interaction contributions
This article studies thermochemistry of solvation of inert gases and organic solutes in ethylene glycol was thoroughly studied using solution calorimetry technique.
Identification and Network-Enabled Characterization of Auxin Response Factor Genes in Medicago truncatula
This article discusses a comprehensive analysis of the Medicago truncatula genome and transcriptome that entailed search for novel Auxin Response Factor genes and the co-expression networks.
Malonylation of Glucosylated N-Lauroylethanolamine: A New Pathway That Determines N-Acylethanolamine Metabolic Fate in Plants
This article focuses on the gene At5g39050, which encodes a phenolic glucoside malonyltransferase 1 (PMAT1), to better understand the biological significance of N-lauroylethanolamine (NAE 12:0)-induced gene expression changes.
Commentary on "Measurement and Correlation of the Solubility of Telmisartan (Form A) in Nine Different Solvents from 277.85 to 338.35 K"
This article presents the correct computation methodology for determining solute descriptors from experimental solubility data.
We need better understanding about functional diversity and vulnerability of tropical freshwater fishes
This commentary extends a discussion initiated by Toussaint et al. (Sci Rep 6:22125, 2016) concerning the relationship between global patterns of freshwater fish functional diversity (FD) and its vulnerability to human impacts.
Generalized parameter-free duality models in discrete minmax fractional programming based on second-order optimality conditions
This article discusses the construction of six generalized second-order parameter-free duality models, and proves several weak, strong, and strict converse duality theorems for a discrete minmax fractional programming problem using two partitioning schemes and various types of generalized second-order (ℱ, β, ɸ, 𝜌, θ, 𝑚)-univexity assumptions.
Being an Informed Consumer of Health Information and Assessment of Electronic Health Literacy in a National Sample of Internet Users: Validity and Reliability of the e-HLS Instrument
This article examines psychometric properties of a new electronic health literacy measure in a national sample of Internet users with specific attention to older users.
Long-Term X-Ray Variability of Typical Active Galactic Nuclei in the Distant Universe
This article discusses the long-term (≈15 years, observed frame) X-ray variability analyses of the 68 brightest radio-quiet active galactic nuclei (AGNs) in the 6 Ms Chandra Deep Field-South survey.
Effects of light on the resistivity of chemical vapor deposited graphene films
This article reports that the resistance of a chemical vapor deposition (CVD) grown graphene film transferred onto an SiO₂ substrate increases to higher saturation values upon exposure to light of decreasing wavelength from the visible to ultraviolet.
Interspecific Differences in Metabolic Rate and Metabolic Temperature Sensitivity Create Distinct Thermal Ecological Niches in Lizards (Plestiodon)
This article examines three congeneric lizards from the southeastern United States (Plestiodon fasciatus, P. inexpectatus, and P. laticeps) and hypothesizes that interspecific differences in metabolic temperature sensitivity locally segregates them across their total range.
A novel statistical method for rare-variant association studies in general pedigrees
In this paper, the authors discuss a novel statistical method for rare-variant association studies in general pedigrees for quantitative traits. This method uses a retrospective view that treats the traits as fixed and the genotypes as random, which accounts for complex and undefined ascertainment of families.
Testing rare variants for hypertension using family-based tests with different weighting schemes
This paper proposes 4 weighting schemes for the family-based rare variants test (FBAT-v) to test for the effects of both rare and common variants across the genome.
More comprehensive forensic genetic marker analyses for accurate human remains identification using massively parallel DNA sequencing
This paper uses massively parallel sequencing (MPS) to characterize 140-year-old human skeletal remains discovered at a historical site in Deadwood, South Dakota, United States.
Novel aromatase inhibitors selection using induced fit docking and extra precision methods: Potential clinical use in ER-alpha-positive breast cancer
This article aims to identify new molecules which could block or suppress the activity of aromatase enzyme by molecular docking studies using Schrödinger-Maestro v9.3.
Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis
This article investigates the effects of chronic developmental hypoxia on cardiac mitochondrial function in embryonic and juvenile American alligators (Alligator mississippiensis).
Importance of the Hydrogen Isocyanide Isomer in Modeling Hydrogen Cyanide Oxidation in Combustion
This article re-examines the chemistry of hydrogen isocyanide (HNC) and its role in combustion nitrogen chemistry.
Unconventional height functions in simultaneous Diophantine approximation
This article discusses three examples of nonstandard height functions, computing their exponents of irrationality as well as giving more precise results.
Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures
This article aims to correlate the solubility of sulfapyridine and sulfadiazine in ethanol + water mixtures by means of the Jouyban-Acree model, and to evaluate the preferential solvation of sulfapyridine in these mixtures by using the inverse Kirkwood-Buff integrals.
Is Exposure to Macondo Oil Reflected in the Otolith Chemistry of Marsh-Resident Fish?
This article evaluates otolith microchemistry as a method for assessing oil exposure history.
ROS Are Good
This opinion article focuses on the possibility that ROS are beneficial to plants, supporting cellular proliferation, physiological function, and viability, and that maintaining a basal level of ROS in cells is essential for life.
Laser Ablated Carbon Nanodots for Light Emission
This article reports the synthesis of fluorescent carbon dots-like nanostructures obtained through the laser ablation of a carbon solid target in liquid environment is reported.
Archaeology, Heritage, and Moral Terrains: Two Cases from the Mesa Verde Region
This article applies an environmental justice lens to two archaeological research narratives, one centering on chemical analysis of biomolecular artifact residues and the other on paleohydrology and Pueblo farming.
Using Paired Depth Interviews to Collect Qualitative Data
This article defines and describes paired depth interviews, discusses conceptualizations of paired depth interviews using Roulston's framework, delineates the strengths and limitations of paired depth interviews, and provides examples of paired depth interviews utilized in helping professions.
Role of exponential type random invexities for asymptotically sufficient efficiency conditions in semi-infinite multi-objective fractional programming
This article introduces several notions of random exponential type asymptotic invexities to establish results to the context of a class of asymptotically sufficient efficiency conditions in semi-infinite multi-objective fractional programing.
Relative Rate and Product Studies of the Reactions of Atomic Chlorine with Tetrafluoroethylene, 1,2-Dichloro-1,2-difluoroethylene, 1,1-Dichloro-2,2-difluoroethylene, and Hexafluoro-1,3-butadiene in the Presence of Oxygen
This article assesses rates of reactions in the context of atmospheric chemistry.
Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks
This article examines the association between World Trade Center (WTC)-related post-traumatic stress disorder and cognitive impairment in WTC responders.