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Genetically engineered probiotic for the treatment of phenylketonuria (PKU); assessment of a novel treatment in vitro and in the PAHᵉⁿᵘ² mouse model of PKU

Description: This article describes the testing of a phenylalanine lyase gene from Anabaena variabilis (AvPAL) codon-optimized and cloned into a shuttle vector for expression in Lactobacillus reuteri 100-23C (pHENOMMenal).
Date: May 17, 2017
Creator: Durrer, Katherine E.; Allen, Michael S. & Hunt von Herbing, Ione

Erratum to: More Comprehensive Forensic Genetic Marker Analyses for Accurate Human Remains Identification Using Massively Parallel DNA Sequencing

Description: This article provides erratum for the article "More Comprehensive Forensic Genetic Marker Analyses for Accurate Human Remains Identification Using Massively Parallel DNA Sequencing," which incorrectly deleted an author from the author list.
Date: April 20, 2017
Creator: Ambers, Angie D.; Churchill, Jennifer D.; King, Jonathan L.; Stoljarova, Monika; Gill-King, Harrell; Assidi, Mourad et al.

Interactions between mitoNEET and NAF-1 in cells

Description: This article uses yeast two-hybrid to demonstrate through vivo bimolecular fluorescence complementation (BiFC), direct coupling analysis (DCA), RNA-sequencing, ROS and iron imaging, and single and double shRNA lines with suppressed mNT, NAF-1 and mNT/NAF-1 expression, that mNT and NAF-1 directly interact in mammalian cells and could function in the same cellular pathway.
Date: April 20, 2017
Creator: Karmi, Ola; Holt, Sarah H.; Song, Luhua; Tamir, Sagi; Luo, Yuting; Bai, Fang et al.

Dry season limnological conditions and basin geology exhibit complex relationships with δ¹³C and δ¹⁵N of carbon sources in four Neotropical floodplains

Description: This article assesses the potential for basin geology and local limnological conditions to predict stable carbon and nitrogen isotope values of six carbon sources at multiple locations in four Neotropical floodplain ecosystems (Paranaá , Pantanal, Araguaia, and Amazon).
Date: March 30, 2017
Creator: Alves, Gustavo H. Zaia; Hoeinghaus, David; Manetta, Gislaine I. & Benedito, Evanilde

A comparison of least squares regression and geographically weighted regression modeling of West Nile virus risk based on environmental parameters

Description: This article discusses the effectiveness of utilizing local spatial variations in environmental data to uncover the statistical relationships between West Nile Virus (WNV) risk and environmental factors.
Date: March 28, 2017
Creator: Kala, Abhishek K.; Tiwari, Chetan; Mikler, Armin R. & Atkinson, Samuel F.

Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4

Description: This article describes findings that demonstrate the affect of diosgenin (DG) on inhibiting the resilient breast cancer stem cells (CSCs) which could provide a benchmark for the development of DG-based therapies in breast cancer treatment.
Date: March 20, 2017
Creator: Bhuvanalakshmi, G.; Basappa; Rangappa, Kanchugarakoppal S.; Dharmarajan, Arunasalam; Sethi, Gautam; Kumar, Alan Prem et al.

Novel transcriptome assembly and comparative toxicity pathway analysis in mahi-mahi (Coryphaena hippurus) embryos and larvae exposed to Deepwater Horizon oil

Description: This article establishes the de novo transcriptomic database from the embryos and larvae of mahi-mahi exposed to water accommodated fractions (HEWAFs) of two Deepwater Horizon oil types (weathered and source oil) in an effort to advance understanding of the molecular aspects involved during specific toxicity responses.
Date: March 15, 2017
Creator: Xu, Elvis Genbo; Mager, Edward M.; Grosell, Martin; Hazard, E. Starr; Hardiman, Gary & Schlenk, Daniel

Computational Identification of Amino-Acid Mutations that Further Improve the Activity of a Chalcone-Flavonone Isomerase from Glycine max

Description: This article discusses a computational approach that combines multiple sequence alignment, positive selection detection, and molecular docking to identify and design beneficial amino-acid mutations that further improve the intramolecular-cyclization activity of a chalcone-flavonone isomerase from Glycine max (GmCHI).
Date: February 24, 2017
Creator: Yuan, Hui; Wu, Jiaqi; Wang, Xiaoqiang; Chen, Jiakuan; Zhong, Yang; Huang, Qiang et al.

Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates

Description: This article describes the use of three members of the human NEET protein family (CISD1, mitoNEET; CISD2, NAF-1 or Miner 1; and CISD3, Miner2) as guides to conduct a phylogenetic analysis of eukaryotic NEET proteins and their evolution.
Date: February 16, 2017
Creator: Inupakutika, Madhuri A.; Sengupta, Soham; Nechushtai, Rachel; Jennings, Patricia A.; Onuchic, José N.; Azad, Rajeev K. et al.

Lophozonia tree cavities used for nesting by Slender-billed Parakeets (Enicognathus leptorhynchus) in the central valley of southern Chile: a potentially vanishing keystone resource

Description: This article describes and quantifies characteristics of southern beech (Lophoonia obliqua) trees and their associated cavities used for nesting by Slender-billed Parakeets in the central valley of southern Chile.
Date: February 6, 2017
Creator: White Jr., Thomas H. & Jiménez, Jaime E.

Wnt signaling in triple-negative breast cancer

Description: This review summarizes the involvement of dysregulated Wnt signaling in the progression of triple-negative breast cancer (TNBC) and TNBC stem cells, as well as the emerging therapies that are currently under investigation.
Date: January 24, 2017
Creator: Pohl, Sebastian Öther-Gee; Brook, N; Agostino, M.; Arfuso, Frank & Kumar, Alan Prem

A chemical genetic screen uncovers a small molecule enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in Arabidopsis

Description: This article demonstrates the feasibility of using an unbiased chemical genetic approach to identify new pharmacological tools for manipulating FAAH- and NAE-mediated physiological processes in plants.
Date: January 23, 2017
Creator: Khan, Bibi Rafeiza; Faure, Lionel; Chapman, Kent D. & Blancaflor, Elison B.

Malonylation of Glucosylated N-Lauroylethanolamine: A New Pathway That Determines N-Acylethanolamine Metabolic Fate in Plants

Description: This article focuses on the gene At5g39050, which encodes a phenolic glucoside malonyltransferase 1 (PMAT1), to better understand the biological significance of N-lauroylethanolamine (NAE 12:0)-induced gene expression changes.
Date: November 17, 2016
Creator: Khan, Bibi Rafeiza; Wherritt, Daniel J.; Huhman, David; Sumner, Lloyd W.; Chapman, Kent D. & Blancaflor, Elison B.

We need better understanding about functional diversity and vulnerability of tropical freshwater fishes

Description: This commentary extends a discussion initiated by Toussaint et al. (Sci Rep 6:22125, 2016) concerning the relationship between global patterns of freshwater fish functional diversity (FD) and its vulnerability to human impacts.
Date: November 11, 2016
Creator: Vitule, Jean R. S.; Agostinho, Angela A.; Azevedo-Santos, Valter M.; Daga, Vanessa S.; Darwall, William R. T.; Fitzgerald, Daniel B. et al.

Interspecific Differences in Metabolic Rate and Metabolic Temperature Sensitivity Create Distinct Thermal Ecological Niches in Lizards (Plestiodon)

Description: This article examines three congeneric lizards from the southeastern United States (Plestiodon fasciatus, P. inexpectatus, and P. laticeps) and hypothesizes that interspecific differences in metabolic temperature sensitivity locally segregates them across their total range.
Date: October 19, 2016
Creator: Watson, Charles M. & Burggren, Warren W.

More comprehensive forensic genetic marker analyses for accurate human remains identification using massively parallel DNA sequencing

Description: This paper uses massively parallel sequencing (MPS) to characterize 140-year-old human skeletal remains discovered at a historical site in Deadwood, South Dakota, United States.
Date: October 17, 2016
Creator: Ambers, Angie D.; Churchill, Jennifer D.; King, Jonathan L.; Stoljarova, Monika; Gill-King, Harrell; Assidi, Mourad et al.

Novel aromatase inhibitors selection using induced fit docking and extra precision methods: Potential clinical use in ER-alpha-positive breast cancer

Description: This article aims to identify new molecules which could block or suppress the activity of aromatase enzyme by molecular docking studies using Schrödinger-Maestro v9.3.
Date: October 10, 2016
Creator: Kumavath, Ranjith; Azad, Manan; Devarapalli, Pratap; Tiwari, Sandeep; Kar, Shreya; Barh, Debmalya et al.

Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis

Description: This article investigates the effects of chronic developmental hypoxia on cardiac mitochondrial function in embryonic and juvenile American alligators (Alligator mississippiensis).
Date: October 5, 2016
Creator: Galli, Gina L. J.; Crossley, Janna; Elsey, Ruth M.; Dzialowski, Edward M. (Edward Michael); Shiels, Holly A. & Crossley, Dane A., II