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open access

Wnt Antagonist, Secreted Frizzled-Related Protein 4 (sFRP4), Increases Chemotherapeutic Response of Glioma Stem-Like Cells

Description: Article on the effect of secreted frizzled-related protein 4, a Wnt signaling antagonist, in chemosensitizing the glioma cell line U138MG and glioma stem cells enriched from U138MG to chemotherapeutics.
Date: 2014
Creator: Warrier, Sudha R.; Balu, Senthil Kumar; Kumar, Alan Prem; Millward, Michael & Dharmarajan, Arunasalam
open access

Loss of Rare Fish Species from Tropical Floodplain Food Webs Affects Community Structure and Ecosystem Multifunctionality in a Mesocosm Experiment

Description: Article on the loss of rare fish species from tropical floodplain food webs and how this affects community structure and ecosystem multifunctionality in a mesocosm experiment.
Date: January 8, 2014
Creator: Pendleton, Richard M.; Hoeinghaus, David; Gomes, Luiz C. & Agostinho, Angela A.
open access

Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid Amide Hydrolase Activity

Description: This article discusses the synthesis of two sets of phenoxyacyl-ethanolamides from natural products, 3-n-pentadecylphenolethanolamide and cardanolethanolamide, with structural similarity to N-Acylethanolamines and characterizes their effects on the hydroltic activity of fatty acid amide hydrolase.
Date: February 20, 2014
Creator: Faure, Lionel; Nagarajan, Subbiah; Hwang, Hyeondo; Montgomery, Christa L.; Khan, Bibi Rafeiza; John, George et al.
open access

Epigenetics as a Source of Variation in Comparative Animal Physiology - or - Lamarck Is Lookin' Pretty Good These Days

Description: This article discusses the ecological and and evolutionary significance of such epigenetic inheritance in a comparative physiological context, and provides a number of caveats and warnings regarding the interpretation of transgenerational phenotype modification as a true epigenetic phenomenon.
Date: February 26, 2014
Creator: Burggren, Warren W.
open access

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

Description: Article on the inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo.
Date: March 21, 2014
Creator: Sethi, Gautam; Chatterjee, Snehajyoti; Rajendran, Peramaiyan; Li, Feng; Shanmugam, Muthu K.; Wong, Kwong Fai et al.
open access

SPHK1 regulates proliferation and survival responses in triple-negative breast cancer

Description: Article describes study suggesting that the inhibation of sphingosine kinase 1 (SPHK1) can attenuate ERK1/2 and AKT signaling and reduce growth of triple-negative breast cancer (TNBC) cells in vitro and in a xenograft SCID mouse model.
Date: March 27, 2014
Creator: Datta, Arpita; Loo, Ser Yue; Huang, Baohua; Wong, Lingkai; Tan, Sheryl S.L.; Tan, Tuan Zea et al.
open access

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mammalian target of rapamycin pathway in an orthotopic mouse model

Description: Article describing an investigation into whether γ-tocotrienol can abrogate angiogenesis-mediated tumor growth in hepatocellular carcinoma (HCC) and if so, through what molecular mechanisms.
Date: March 31, 2014
Creator: Siveen, Kodappully Sivaraman; Ahn, Kwang Seok; Ong, Tina H.; Shanmugam, Muthu K.; Li, Feng; Yap, Wei Ney et al.
open access

Draft Genome Sequence of Cupriavidus sp. Strain SK-4, a di-ortho-Substituted Biphenyl-Utilizing Bacterium Isolated from Polychlorinated Biphenyl-Contaminated Sludge

Description: Article on the draft genome sequence of Cupriavidus sp. strain SK-4, a di-ortho-substituted biphenyl-utilizing bacterium isolated from polychlorinated biphenyl-contaminated sludge.
Date: May 22, 2014
Creator: Vilo, Claudia A.; Benedik, Michael J.; Ilori, Matthew Olusoji & Dong, Qunfeng
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