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Comparative Study of RSS-Based Collaborative Localization Methods in Wireless Sensor Networks

Description: In this thesis two collaborative localization techniques are studied: multidimensional scaling (MDS) and maximum likelihood estimator (MLE). A synthesis of a new location estimation method through a serial integration of these two techniques, such that an estimate is first obtained using MDS and then MLE is employed to fine-tune the MDS solution, was the subject of this research using various simulation and experimental studies. In the simulations, important issues including the effects of sensor node density, reference node density and different deployment strategies of reference nodes were addressed. In the experimental study, the path loss model of indoor environments is developed by determining the environment-specific parameters from the experimental measurement data. Then, the empirical path loss model is employed in the analysis and simulation study of the performance of collaborative localization techniques.
Date: December 2006
Creator: Koneru, Avanthi

Computational Epidemiology - Analyzing Exposure Risk: A Deterministic, Agent-Based Approach

Description: Many infectious diseases are spread through interactions between susceptible and infectious individuals. Keeping track of where each exposure to the disease took place, when it took place, and which individuals were involved in the exposure can give public health officials important information that they may use to formulate their interventions. Further, knowing which individuals in the population are at the highest risk of becoming infected with the disease may prove to be a useful tool for public health officials trying to curtail the spread of the disease. Epidemiological models are needed to allow epidemiologists to study the population dynamics of transmission of infectious agents and the potential impact of infectious disease control programs. While many agent-based computational epidemiological models exist in the literature, they focus on the spread of disease rather than exposure risk. These models are designed to simulate very large populations, representing individuals as agents, and using random experiments and probabilities in an attempt to more realistically guide the course of the modeled disease outbreak. The work presented in this thesis focuses on tracking exposure risk to chickenpox in an elementary school setting. This setting is chosen due to the high level of detailed information realistically available to school administrators regarding individuals' schedules and movements. Using an agent-based approach, contacts between individuals are tracked and analyzed with respect to both individuals and locations. The results are then analyzed using a combination of tools from computer science and geographic information science.
Date: August 2009
Creator: O'Neill II, Martin Joseph

A Computational Methodology for Addressing Differentiated Access of Vulnerable Populations During Biological Emergencies

Description: Mitigation response plans must be created to protect affected populations during biological emergencies resulting from the release of harmful biochemical substances. Medical countermeasures have been stockpiled by the federal government for such emergencies. However, it is the responsibility of local governments to maintain solid, functional plans to apply these countermeasures to the entire target population within short, mandated time frames. Further, vulnerabilities in the population may serve as barriers preventing certain individuals from participating in mitigation activities. Therefore, functional response plans must be capable of reaching vulnerable populations.Transportation vulnerability results from lack of access to transportation. Transportation vulnerable populations located too far from mitigation resources are at-risk of not being able to participate in mitigation activities. Quantification of these populations requires the development of computational methods to integrate spatial demographic data and transportation resource data from disparate sources into the context of planned mitigation efforts. Research described in this dissertation focuses on quantifying transportation vulnerable populations and maximizing participation in response efforts. Algorithms developed as part of this research are integrated into a computational framework to promote a transition from research and development to deployment and use by biological emergency planners.
Date: August 2014
Creator: O’Neill II, Martin Joseph

Computational Methods for Discovering and Analyzing Causal Relationships in Health Data

Description: Publicly available datasets in health science are often large and observational, in contrast to experimental datasets where a small number of data are collected in controlled experiments. Variables' causal relationships in the observational dataset are yet to be determined. However, there is a significant interest in health science to discover and analyze causal relationships from health data since identified causal relationships will greatly facilitate medical professionals to prevent diseases or to mitigate the negative effects of the disease. Recent advances in Computer Science, particularly in Bayesian networks, has initiated a renewed interest for causality research. Causal relationships can be possibly discovered through learning the network structures from data. However, the number of candidate graphs grows in a more than exponential rate with the increase of variables. Exact learning for obtaining the optimal structure is thus computationally infeasible in practice. As a result, heuristic approaches are imperative to alleviate the difficulty of computations. This research provides effective and efficient learning tools for local causal discoveries and novel methods of learning causal structures with a combination of background knowledge. Specifically in the direction of constraint based structural learning, polynomial-time algorithms for constructing causal structures are designed with first-order conditional independence. Algorithms of efficiently discovering non-causal factors are developed and proved. In addition, when the background knowledge is partially known, methods of graph decomposition are provided so as to reduce the number of conditioned variables. Experiments on both synthetic data and real epidemiological data indicate the provided methods are applicable to large-scale datasets and scalable for causal analysis in health data. Followed by the research methods and experiments, this dissertation gives thoughtful discussions on the reliability of causal discoveries computational health science research, complexity, and implications in health science research.
Date: August 2015
Creator: Liang, Yiheng

Computational Methods for Vulnerability Analysis and Resource Allocation in Public Health Emergencies

Description: POD (Point of Dispensing)-based emergency response plans involving mass prophylaxis may seem feasible when considering the choice of dispensing points within a region, overall population density, and estimated traffic demands. However, the plan may fail to serve particular vulnerable sub-populations, resulting in access disparities during emergency response. Federal authorities emphasize on the need to identify sub-populations that cannot avail regular services during an emergency due to their special needs to ensure effective response. Vulnerable individuals require the targeted allocation of appropriate resources to serve their special needs. Devising schemes to address the needs of vulnerable sub-populations is essential for the effectiveness of response plans. This research focuses on data-driven computational methods to quantify and address vulnerabilities in response plans that require the allocation of targeted resources. Data-driven methods to identify and quantify vulnerabilities in response plans are developed as part of this research. Addressing vulnerabilities requires the targeted allocation of appropriate resources to PODs. The problem of resource allocation to PODs during public health emergencies is introduced and the variants of the resource allocation problem such as the spatial allocation, spatio-temporal allocation and optimal resource subset variants are formulated. Generating optimal resource allocation and scheduling solutions can be computationally hard problems. The application of metaheuristic techniques to find near-optimal solutions to the resource allocation problem in response plans is investigated. A vulnerability analysis and resource allocation framework that facilitates the demographic analysis of population data in the context of response plans, and the optimal allocation of resources with respect to the analysis are described.
Date: August 2015
Creator: Indrakanti, Saratchandra

Content and Temporal Analysis of Communications to Predict Task Cohesion in Software Development Global Teams

Description: Virtual teams in industry are increasingly being used to develop software, create products, and accomplish tasks. However, analyzing those collaborations under same-time/different-place conditions is well-known to be difficult. In order to overcome some of these challenges, this research was concerned with the study of collaboration-based, content-based and temporal measures and their ability to predict cohesion within global software development projects. Messages were collected from three software development projects that involved students from two different countries. The similarities and quantities of these interactions were computed and analyzed at individual and group levels. Results of interaction-based metrics showed that the collaboration variables most related to Task Cohesion were Linguistic Style Matching and Information Exchange. The study also found that Information Exchange rate and Reply rate have a significant and positive correlation to Task Cohesion, a factor used to describe participants' engagement in the global software development process. This relation was also found at the Group level. All these results suggest that metrics based on rate can be very useful for predicting cohesion in virtual groups. Similarly, content features based on communication categories were used to improve the identification of Task Cohesion levels. This model showed mixed results, since only Work similarity and Social rate were found to be correlated with Task Cohesion. This result can be explained by how a group's cohesiveness is often associated with fairness and trust, and that these two factors are often achieved by increased social and work communications. Also, at a group-level, all models were found correlated to Task Cohesion, specifically, Similarity+Rate, which suggests that models that include social and work communication categories are also good predictors of team cohesiveness. Finally, temporal interaction similarity measures were calculated to assess their prediction capabilities in a global setting. Results showed a significant negative correlation between the Pacing Rate and ...
Date: May 2017
Creator: Castro Hernandez, Alberto

Cross Language Information Retrieval for Languages with Scarce Resources

Description: Our generation has experienced one of the most dramatic changes in how society communicates. Today, we have online information on almost any imaginable topic. However, most of this information is available in only a few dozen languages. In this thesis, I explore the use of parallel texts to enable cross-language information retrieval (CLIR) for languages with scarce resources. To build the parallel text I use the Bible. I evaluate different variables and their impact on the resulting CLIR system, specifically: (1) the CLIR results when using different amounts of parallel text; (2) the role of paraphrasing on the quality of the CLIR output; (3) the impact on accuracy when translating the query versus translating the collection of documents; and finally (4) how the results are affected by the use of different dialects. The results show that all these variables have a direct impact on the quality of the CLIR system.
Date: May 2009
Creator: Loza, Christian

Cuff-less Blood Pressure Measurement Using a Smart Phone

Description: Blood pressure is vital sign information that physicians often need as preliminary data for immediate intervention during emergency situations or for regular monitoring of people with cardiovascular diseases. Despite the availability of portable blood pressure meters in the market, they are not regularly carried by people, creating a need for an ultra-portable measurement platform or device that can be easily carried and used at all times. One such device is the smartphone which, according to comScore survey is used by 26.2% of the US adult population. the mass production of these phones with built-in sensors and high computation power has created numerous possibilities for application development in different domains including biomedical. Motivated by this capability and their extensive usage, this thesis focuses on developing a blood pressure measurement platform on smartphones. Specifically, I developed a blood pressure measurement system on a smart phone using the built-in camera and a customized external microphone. the system consists of first obtaining heart beats using the microphone and finger pulse with the camera, and finally calculating the blood pressure using the recorded data. I developed techniques for finding the best location for obtaining the data, making the system usable by all categories of people. the proposed system resulted in accuracies between 90-100%, when compared to traditional blood pressure meters. the second part of this thesis presents a new system for remote heart beat monitoring using the smart phone. with the proposed system, heart beats can be transferred live by patients and monitored by physicians remotely for diagnosis. the proposed blood pressure measurement and remote monitoring systems will be able to facilitate information acquisition and decision making by the 9-1-1 operators.
Date: May 2012
Creator: Jonnada, Srikanth

Ddos Defense Against Botnets in the Mobile Cloud

Description: Mobile phone advancements and ubiquitous internet connectivity are resulting in ever expanding possibilities in the application of smart phones. Users of mobile phones are now capable of hosting server applications from their personal devices. Whether providing services individually or in an ad hoc network setting the devices are currently not configured for defending against distributed denial of service (DDoS) attacks. These attacks, often launched from a botnet, have existed in the space of personal computing for decades but recently have begun showing up on mobile devices. Research is done first into the required steps to develop a potential botnet on the Android platform. This includes testing for the amount of malicious traffic an Android phone would be capable of generating for a DDoS attack. On the other end of the spectrum is the need of mobile devices running networked applications to develop security against DDoS attacks. For this mobile, phones are setup, with web servers running Apache to simulate users running internet connected applications for either local ad hoc networks or serving to the internet. Testing is done for the viability of using commonly available modules developed for Apache and intended for servers as well as finding baseline capabilities of mobiles to handle higher traffic volumes. Given the unique challenge of the limited resources a mobile phone can dedicate to Apache when compared to a dedicated hosting server a new method was needed. A proposed defense algorithm is developed for mitigating DDoS attacks against the mobile server that takes into account the limited resources available on the mobile device. The algorithm is tested against TCP socket flooding for effectiveness and shown to perform better than the common Apache module installations on a mobile device.
Date: May 2014
Creator: Jensen, David

Design and Analysis of Novel Verifiable Voting Schemes

Description: Free and fair elections are the basis for democracy, but conducting elections is not an easy task. Different groups of people are trying to influence the outcome of the election in their favor using the range of methods, from campaigning for a particular candidate to well-financed lobbying. Often the stakes are too high, and the methods are illegal. Two main properties of any voting scheme are the privacy of a voter’s choice and the integrity of the tally. Unfortunately, they are mutually exclusive. Integrity requires making elections transparent and auditable, but at the same time, we must preserve a voter’s privacy. It is always a trade-off between these two requirements. Current voting schemes favor privacy over auditability, and thus, they are vulnerable to voting fraud. I propose two novel voting systems that can achieve both privacy and verifiability. The first protocol is based on cryptographical primitives to ensure the integrity of the final tally and privacy of the voter. The second protocol is a simple paper-based voting scheme that achieves almost the same level of security without usage of cryptography.
Date: December 2013
Creator: Yestekov, Yernat

Design and Implementation of Large-Scale Wireless Sensor Networks for Environmental Monitoring Applications

Description: Environmental monitoring represents a major application domain for wireless sensor networks (WSN). However, despite significant advances in recent years, there are still many challenging issues to be addressed to exploit the full potential of the emerging WSN technology. In this dissertation, we introduce the design and implementation of low-power wireless sensor networks for long-term, autonomous, and near-real-time environmental monitoring applications. We have developed an out-of-box solution consisting of a suite of software, protocols and algorithms to provide reliable data collection with extremely low power consumption. Two wireless sensor networks based on the proposed solution have been deployed in remote field stations to monitor soil moisture along with other environmental parameters. As parts of the ever-growing environmental monitoring cyberinfrastructure, these networks have been integrated into the Texas Environmental Observatory system for long-term operation. Environmental measurement and network performance results are presented to demonstrate the capability, reliability and energy-efficiency of the network.
Date: May 2010
Creator: Yang, Jue

The Design Of A Benchmark For Geo-stream Management Systems

Description: The recent growth in sensor technology allows easier information gathering in real-time as sensors have grown smaller, more accurate, and less expensive. The resulting data is often in a geo-stream format continuously changing input with a spatial extent. Researchers developing geo-streaming management systems (GSMS) require a benchmark system for evaluation, which is currently lacking. This thesis presents GSMark, a benchmark for evaluating GSMSs. GSMark provides a data generator that creates a combination of synthetic and real geo-streaming data, a workload simulator to present the data to the GSMS as a data stream, and a set of benchmark queries that evaluate typical GSMS functionality and query performance. In particular, GSMark generates both moving points and evolving spatial regions, two fundamental data types for a broad range of geo-stream applications, and the geo-streaming queries on this data.
Date: December 2011
Creator: Shen, Chao

Detection of Temporal Events and Abnormal Images for Quality Analysis in Endoscopy Videos

Description: Recent reports suggest that measuring the objective quality is very essential towards the success of colonoscopy. Several quality indicators (i.e. metrics) proposed in recent studies are implemented in software systems that compute real-time quality scores for routine screening colonoscopy. Most quality metrics are derived based on various temporal events occurred during the colonoscopy procedure. The location of the phase boundary between the insertion and the withdrawal phases and the amount of circumferential inspection are two such important temporal events. These two temporal events can be determined by analyzing various camera motions of the colonoscope. This dissertation put forward a novel method to estimate X, Y and Z directional motions of the colonoscope using motion vector templates. Since abnormalities of a WCE or a colonoscopy video can be found in a small number of frames (around 5% out of total frames), it is very helpful if a computer system can decide whether a frame has any mucosal abnormalities. Also, the number of detected abnormal lesions during a procedure is used as a quality indicator. Majority of the existing abnormal detection methods focus on detecting only one type of abnormality or the overall accuracies are somewhat low if the method tries to detect multiple abnormalities. Most abnormalities in endoscopy images have unique textures which are clearly distinguishable from normal textures. In this dissertation a new method is proposed that achieves the objective of detecting multiple abnormalities with a higher accuracy using a multi-texture analysis technique. The multi-texture analysis method is designed by representing WCE and colonoscopy image textures as textons.
Date: August 2013
Creator: Nawarathna, Ruwan D.

Detection of Ulcerative Colitis Severity and Enhancement of Informative Frame Filtering Using Texture Analysis in Colonoscopy Videos

Description: There are several types of disorders that affect our colon’s ability to function properly such as colorectal cancer, ulcerative colitis, diverticulitis, irritable bowel syndrome and colonic polyps. Automatic detection of these diseases would inform the endoscopist of possible sub-optimal inspection during the colonoscopy procedure as well as save time during post-procedure evaluation. But existing systems only detects few of those disorders like colonic polyps. In this dissertation, we address the automatic detection of another important disorder called ulcerative colitis. We propose a novel texture feature extraction technique to detect the severity of ulcerative colitis in block, image, and video levels. We also enhance the current informative frame filtering methods by detecting water and bubble frames using our proposed technique. Our feature extraction algorithm based on accumulation of pixel value difference provides better accuracy at faster speed than the existing methods making it highly suitable for real-time systems. We also propose a hybrid approach in which our feature method is combined with existing feature method(s) to provide even better accuracy. We extend the block and image level detection method to video level severity score calculation and shot segmentation. Also, the proposed novel feature extraction method can detect water and bubble frames in colonoscopy videos with very high accuracy in significantly less processing time even when clustering is used to reduce the training size by 10 times.
Date: December 2015
Creator: Dahal, Ashok

Determining Whether and When People Participate in the Events They Tweet About

Description: This work describes an approach to determine whether people participate in the events they tweet about. Specifically, we determine whether people are participants in events with respect to the tweet timestamp. We target all events expressed by verbs in tweets, including past, present and events that may occur in future. We define event participant as people directly involved in an event regardless of whether they are the agent, recipient or play another role. We present an annotation effort, guidelines and quality analysis with 1,096 event mentions. We discuss the label distributions and event behavior in the annotated corpus. We also explain several features used and a standard supervised machine learning approach to automatically determine if and when the author is a participant of the event in the tweet. We discuss trends in the results obtained and devise important conclusions.
Date: May 2017
Creator: Sanagavarapu, Krishna Chaitanya

Development, Implementation, and Analysis of a Contact Model for an Infectious Disease

Description: With a growing concern of an infectious diseases spreading in a population, epidemiology is becoming more important for the future of public health. In the past epidemiologist used existing data of an outbreak to help them determine how an infectious disease might spread in the future. Now with computational models, they able to analysis data produced by these models to help with prevention and intervention plans. This paper looks at the design, implementation, and analysis of a computational model based on the interactions of the population between individuals. The design of the working contact model looks closely at the SEIR model used as the foundation and the two timelines of a disease. The implementation of the contact model is reviewed while looking closely at data structures. The analysis of the experiments provide evidence this contact model can be used to help epidemiologist study the spread of an infectious disease based on the contact rate of individuals.
Date: May 2009
Creator: Thompson, Brett Morinaga

Direct Online/Offline Digital Signature Schemes.

Description: Online/offline signature schemes are useful in many situations, and two such scenarios are considered in this dissertation: bursty server authentication and embedded device authentication. In this dissertation, new techniques for online/offline signing are introduced, those are applied in a variety of ways for creating online/offline signature schemes, and five different online/offline signature schemes that are proved secure under a variety of models and assumptions are proposed. Two of the proposed five schemes have the best offline or best online performance of any currently known technique, and are particularly well-suited for the scenarios that are considered in this dissertation. To determine if the proposed schemes provide the expected practical improvements, a series of experiments were conducted comparing the proposed schemes with each other and with other state-of-the-art schemes in this area, both on a desktop class computer, and under AVR Studio, a simulation platform for an 8-bit processor that is popular for embedded systems. Under AVR Studio, the proposed SGE scheme using a typical key size for the embedded device authentication scenario, can complete the offline phase in about 24 seconds and then produce a signature (the online phase) in 15 milliseconds, which is the best offline performance of any known signature scheme that has been proven secure in the standard model. In the tests on a desktop class computer, the proposed SGS scheme, which has the best online performance and is designed for the bursty server authentication scenario, generated 469,109 signatures per second, and the Schnorr scheme (the next best scheme in terms of online performance) generated only 223,548 signatures. The experimental results demonstrate that the SGE and SGS schemes are the most efficient techniques for embedded device authentication and bursty server authentication, respectively.
Date: December 2008
Creator: Yu, Ping

Distributed Frameworks Towards Building an Open Data Architecture

Description: Data is everywhere. The current Technological advancements in Digital, Social media and the ease at which the availability of different application services to interact with variety of systems are causing to generate tremendous volumes of data. Due to such varied services, Data format is now not restricted to only structure type like text but can generate unstructured content like social media data, videos and images etc. The generated Data is of no use unless been stored and analyzed to derive some Value. Traditional Database systems comes with limitations on the type of data format schema, access rates and storage sizes etc. Hadoop is an Apache open source distributed framework that support storing huge datasets of different formatted data reliably on its file system named Hadoop File System (HDFS) and to process the data stored on HDFS using MapReduce programming model. This thesis study is about building a Data Architecture using Hadoop and its related open source distributed frameworks to support a Data flow pipeline on a low commodity hardware. The Data flow components are, sourcing data, storage management on HDFS and data access layer. This study also discuss about a use case to utilize the architecture components. Sqoop, a framework to ingest the structured data from database onto Hadoop and Flume is used to ingest the semi-structured Twitter streaming json data on to HDFS for analysis. The data sourced using Sqoop and Flume have been analyzed using Hive for SQL like analytics and at a higher level of data access layer, Hadoop has been compared with an in memory computing system using Spark. Significant differences in query execution performances have been analyzed when working with Hadoop and Spark frameworks. This integration helps for ingesting huge Volumes of streaming json Variety data to derive better Value based analytics using Hive and ...
Date: May 2015
Creator: Venumuddala, Ramu Reddy

A Driver, Vehicle and Road Safety System Using Smartphones

Description: As vehicle manufacturers continue to increase their emphasis on safety with advanced driver assistance systems (ADAS), I propose a ubiquitous device that is able to analyze and advise on safety conditions. Mobile smartphones are increasing in popularity among younger generations with an estimated 64% of 25-34 year olds already using one in their daily lives. with over 10 million car accidents reported in the United States each year, car manufacturers have shifted their focus of a passive approach (airbags) to more active by adding features associated with ADAS (lane departure warnings). However, vehicles manufactured with these sensors are not economically priced while older vehicles might only have passive safety features. Given its accessibility and portability, I target a mobile smartphone as a device to compliment ADAS that can bring a driver assist to any vehicle without regards for any on-vehicle communication system requirements. I use the 3-axis accelerometer of multiple Android based smartphone to record and analyze various safety factors which can influence a driver while operating a vehicle. These influences with respect to the driver, vehicle and road are lane change maneuvers, vehicular comfort and road conditions. Each factor could potentially be hazardous to the health of the driver, neighboring public, and automobile and is therefore analyzed thoroughly achieving 85.60% and 89.89% classification accuracy for identifying road anomalies and lane changes, respectively. Effective use of this data can educate a potentially dangerous driver on how to operate a vehicle safely and efficiently. with real time analysis and auditory alerts of these factors, I hope to increase a driver's overall awareness to maximize safety.
Date: May 2012
Creator: Gozick, Brandon

A Dual Dielectric Approach for Performance Aware Reduction of Gate Leakage in Combinational Circuits

Description: Design of systems in the low-end nanometer domain has introduced new dimensions in power consumption and dissipation in CMOS devices. With continued and aggressive scaling, using low thickness SiO2 for the transistor gates, gate leakage due to gate oxide direct tunneling current has emerged as the major component of leakage in the CMOS circuits. Therefore, providing a solution to the issue of gate oxide leakage has become one of the key concerns in achieving low power and high performance CMOS VLSI circuits. In this thesis, a new approach is proposed involving dual dielectric of dual thicknesses (DKDT) for the reducing both ON and OFF state gate leakage. It is claimed that the simultaneous utilization of SiON and SiO2 each with multiple thicknesses is a better approach for gate leakage reduction than the conventional usage of a single gate dielectric (SiO2), possibly with multiple thicknesses. An algorithm is developed for DKDT assignment that minimizes the overall leakage for a circuit without compromising with the performance. Extensive experiments were carried out on ISCAS'85 benchmarks using 45nm technology which showed that the proposed approach can reduce the leakage, as much as 98% (in an average 89.5%), without degrading the performance.
Date: May 2006
Creator: Mukherjee, Valmiki

Effective and Accelerated Informative Frame Filtering in Colonoscopy Videos Using Graphic Processing Units

Description: Colonoscopy is an endoscopic technique that allows a physician to inspect the mucosa of the human colon. Previous methods and software solutions to detect informative frames in a colonoscopy video (a process called informative frame filtering or IFF) have been hugely ineffective in (1) covering the proper definition of an informative frame in the broadest sense and (2) striking an optimal balance between accuracy and speed of classification in both real-time and non real-time medical procedures. In my thesis, I propose a more effective method and faster software solutions for IFF which is more effective due to the introduction of a heuristic algorithm (derived from experimental analysis of typical colon features) for classification. It contributed to a 5-10% boost in various performance metrics for IFF. The software modules are faster due to the incorporation of sophisticated parallel-processing oriented coding techniques on modern microprocessors. Two IFF modules were created, one for post-procedure and the other for real-time. Code optimizations through NVIDIA CUDA for GPU processing and/or CPU multi-threading concepts embedded in two significant microprocessor design philosophies (multi-core design and many-core design) resulted a 5-fold acceleration for the post-procedure module and a 40-fold acceleration for the real-time module. Some innovative software modules, which are still in testing phase, have been recently created to exploit the power of multiple GPUs together.
Date: August 2010
Creator: Karri, Venkata Praveen

Elicitation of Protein-Protein Interactions from Biomedical Literature Using Association Rule Discovery

Description: Extracting information from a stack of data is a tedious task and the scenario is no different in proteomics. Volumes of research papers are published about study of various proteins in several species, their interactions with other proteins and identification of protein(s) as possible biomarker in causing diseases. It is a challenging task for biologists to keep track of these developments manually by reading through the literatures. Several tools have been developed by computer linguists to assist identification, extraction and hypotheses generation of proteins and protein-protein interactions from biomedical publications and protein databases. However, they are confronted with the challenges of term variation, term ambiguity, access only to abstracts and inconsistencies in time-consuming manual curation of protein and protein-protein interaction repositories. This work attempts to attenuate the challenges by extracting protein-protein interactions in humans and elicit possible interactions using associative rule mining on full text, abstracts and captions from figures available from publicly available biomedical literature databases. Two such databases are used in our study: Directory of Open Access Journals (DOAJ) and PubMed Central (PMC). A corpus is built using articles based on search terms. A dataset of more than 38,000 protein-protein interactions from the Human Protein Reference Database (HPRD) is cross-referenced to validate discovered interactive pairs. A set of an optimal size of possible binary protein-protein interactions is generated to be made available for clinician or biological validation. A significant change in the number of new associations was found by altering the thresholds for support and confidence metrics. This study narrows down the limitations for biologists in keeping pace with discovery of protein-protein interactions via manually reading the literature and their needs to validate each and every possible interaction.
Date: August 2010
Creator: Samuel, Jarvie John

An Empirical Evaluation of Communication and Coordination Effectiveness in Autonomous Reactive Multiagent Systems

Description: This thesis describes experiments designed to measure the effect of collaborative communication on task performance of a multiagent system. A discrete event simulation was developed to model a multi-agent system completing a task to find and collect food resources, with the ability to substitute various communication and coordination methods. Experiments were conducted to find the effects of the various communication methods on completion of the task to find and harvest the food resources. Results show that communication decreases the time required to complete the task. However, all communication methods do not fare equally well. In particular, results indicate that the communication model of the bee is a particularly effective method of agent communication and collaboration. Furthermore, results indicate that direct communication with additional information content provides better completion results. Cost-benefit models show some conflicting information, indicating that the increased performance may not offset the additional cost of achieving that performance.
Date: May 2005
Creator: Hurt, David

An Empirical Study of How Novice Programmers Use the Web

Description: Students often use the web as a source of help for problems that they encounter on programming assignments.In this work, we seek to understand how students use the web to search for help on their assignments.We used a mixed methods approach with 344 students who complete a survey and 41 students who participate in a focus group meetings and helped in recording data about their search habits.The survey reveals data about student reported search habits while the focus group uses a web browser plug-in to record actual search patterns.We examine the results collectively and as broken down by class year.Survey results show that at least 2/3 of the students from each class year rely on search engines to locate resources for help with their programming bugs in at least half of their assignments;search habits vary by class year;and the value of different types of resources such as tutorials and forums varies by class year.Focus group results exposes the high frequency web sites used by the students in solving their programming assignments.
Date: May 2016
Creator: Tula, Naveen