A High-fat Meal Alters Post-prandial mRNA Expression of SIRT1, SIRT4, and SIRT6
Description:
Sirtuins (SIRT) regulate the transcription of various genes involved in the development of diet-induced obesity and chronic disease; however, it is unknown how they change acutely following a high-fat meal. The purpose of this study was to determine the effect of a high-fat meal (65% kcals/d; 85% fat recommendation), on SIRT1-7 mRNA expression in blood leukocytes at 1, 3, and 5-h post-prandial. Men and women (N=24) reported to the lab following an overnight fast (>12H). Total RNA was isolated a…
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Date:
December 2015
Creator:
Best Sampson, Jill Nicole