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Barbituric Acids. VII. 5-alkyl-derivatives of 5-ethoxy-barbituric Acid

Description: A great deal of research has been devoted in recent years to the search for new drugs for the treatment of epilepsy and related convulsive disorders. This emphasis is occasioned by the fact that no one drug is effective for all patients, and also by the fact that the toxicity of a drug varies considerably from one patient to another. Among the most effective drugs are certain members of the hydantoin and barbituric acid series. For some time there has been in progress in this laboratory an inve… more
Date: January 1955
Creator: Hyde, Harold Wayne
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The Synthesis of Benzo(d)pyrido(a)-benzimidazole-5,12-quinone

Description: The present investigation yielded an orange product upon refluxing 2-butyramido-3-chloro-1,4-naphthoquinone and 2-aminopyridine in ethanol. When this material was purified, by recrystallization from glacial acetic acid, the melting point was 306 [degrees]. This compound has been shown to be benzo(d)pyrido(a)-benzimidazole-5,12-quinone by the present investigation.
Date: May 1955
Creator: Cooper, James Erwin
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The Preparation of Pyridinium Derivatives by the Knoevenagel Condensation

Description: An attempt is made in the work described in this paper to extend the series started by Hall and Platas by means of a Knoevenagel condensation between 3-hydroxy-1,4-naphtho-quinone-2-(4-methylpyridinium) anhydride and various aromatic aldehydes giving rise to a series of unsaturated substituents on the four position of the pyridine ring.
Date: May 1955
Creator: Miller, Eugene James
open access

Naphthoquinone Studies

Description: This thesis describes a series of naphthoquinone reactions employing pyridine carboxylic acid derivatives (nicotinic acid derivatives). The products of these reactions will be tested by Parke, Davis and Company for their activity against the tubercle bacillus and other pathogenic microorganisms.
Date: 1955
Creator: Padgett, William A.
open access

Pyridine-N-Oxide Derivatives of Naphthoquinone

Description: This thesis describes a series of pyridine-N-oxide derivatives of naphthoquinone that were prepared by the author. These compounds will be tested for medicinal activity by Parke-Davis and Company.
Date: 1955
Creator: Talbott, Ted Delwyn
open access

Preparation of Pyridinium Derivatives of 2,3-Dichloro-5(8?)-Nitro-1,4-Naphthoquinone

Description: This paper describes the preparation of pyridine derivatives of 2,3-dichloro-5(8?)-nitro-1,4-naphthoquinone. A method for the nitration of 2,3-dichloro-1,4-naphthoquinone is also described. Certain 4-n-alkyl, 3,4-dialkyl, and 4-cycloalkyl pyridine derivatives are caused to undergo condensation reactions with the nitrated naphthoquinone, giving rise to a series of compounds of the preceding type (X). All of the compounds prepared will be tested for anti-tubercular activity by Parke-Davis and Com… more
Date: 1955
Creator: Mahon, Frank
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