UNT Libraries - 63 Matching Results

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Nitration of Thiophene Analogs of DDT

Description: Since thiophene very often yields compounds that are analogous to benzene derivatives in general physiological properties, it was decided to attempt to prepare the nitro and amino derivatives of 1,1,1-trichloro-2,2-bis-(2-thienyl)-ethane (V) as well as the nitro and amino derivatives of 2,2,3-trichloro-1,1-bis-(2-thienyl)-butane (VI).
Date: February 1953
Creator: Buttram, Jack Rhea

Barbituric Acids. V. 5-substituted-mercapto Derivatives of 5-isoamylbarbituric Acid

Description: Since no mention has been found in the literature of any 5-substituted mercapto-5-alkyl derivatives of barbituric acid, it was thought to be of interest to prepare a series of compounds containing sulfur attached directly to the barbituric acid nucleus. 5-substituted mercapto-5-isoamylbarbituric acids were chosen as representative of barbituric acids in which the alkyl group has a fairly high molecular weight.
Date: August 1952
Creator: Peterson, Paul Eugene

The Adsorption of Radioactive Isotopes on Precipitates

Description: This thesis concerns the investigation of radioisotopes as indicators for precipitation reactions. As a precipitate forms in the presence of a radioisotope, adsorption may take place on its surface. If this adsorption changes markedly at the stoichiometric point it will be possible to use this variation as an indicator for the reaction.
Date: January 1954
Creator: Bulloch, Newman Payne

Hydantoins as Anticonvulsants. VIII. 5-Alkylmercapto Derivatives of 3-Methyl-5-Phenylhydantoin

Description: Recent years have seen a rapid increase in the search for new compounds to be employed in the treatment of convulsions associated with epilepsy and related ailments. The properties desired are a higher degree of effectiveness and lower toxicity than those already in use. This thesis describes the effect of methylation of the 5-alkylmercapto-5-phenylhydantoins.
Date: January 1954
Creator: Dick, Clarence Reinhardt

Hydantoins as Anticonvulsants. VI. 5-Substituted-Alkoxy Derivatives of 5-Phenylhydantoin

Description: No derivatives of 5-phenylhydantoin with an oxygen atom attached directly in the five position of the hydantoin nucleus have been found in the literature. It was therefore considered of interest to synthesize a series of compounds of this type to determine the effect of the change of the position of the oxygen atom on anticonvulsant activity.
Date: January 1954
Creator: Hoffman, James Rucker

Barbituric Acids. VII. 5-alkyl-derivatives of 5-ethoxy-barbituric Acid

Description: A great deal of research has been devoted in recent years to the search for new drugs for the treatment of epilepsy and related convulsive disorders. This emphasis is occasioned by the fact that no one drug is effective for all patients, and also by the fact that the toxicity of a drug varies considerably from one patient to another. Among the most effective drugs are certain members of the hydantoin and barbituric acid series. For some time there has been in progress in this laboratory an investigation of members of these two series in which a hetro atom attached directly to the hetrocyclic nucleus is introduced into the side chain at position five of these two series.
Date: January 1955
Creator: Hyde, Harold Wayne

The Synthesis of Benzo(d)pyrido(a)-benzimidazole-5,12-quinone

Description: The present investigation yielded an orange product upon refluxing 2-butyramido-3-chloro-1,4-naphthoquinone and 2-aminopyridine in ethanol. When this material was purified, by recrystallization from glacial acetic acid, the melting point was 306 [degrees]. This compound has been shown to be benzo(d)pyrido(a)-benzimidazole-5,12-quinone by the present investigation.
Date: May 1955
Creator: Cooper, James Erwin

The Preparation of Pyridinium Derivatives by the Knoevenagel Condensation

Description: An attempt is made in the work described in this paper to extend the series started by Hall and Platas by means of a Knoevenagel condensation between 3-hydroxy-1,4-naphtho-quinone-2-(4-methylpyridinium) anhydride and various aromatic aldehydes giving rise to a series of unsaturated substituents on the four position of the pyridine ring.
Date: May 1955
Creator: Miller, Eugene James

Nitrogen Derivatives of Naphthoquinone

Description: A series of nitrogen derivatives of 1,4-naphthoquinone, which are structurally similar to the compounds of Hall, has been prepared by this worker. In general, the amido groups are those of the long-chain, fatty acids, and it is believed they will have increased physiological activity. These compounds are to be tested for medicinal activity by Parke-Davis and Company.
Date: June 1953
Creator: Wood, Frank M.

Barbituric Acids. VIII. 5-substituted-5-(1-pyrrolidyl)barbituric Acids

Description: The purpose of this investigation then was the preparation of a series of 5-substituted-5-(1-pyrrolidyl)barbituric acids in which R would consist of alkyl groups ranging in size from methyl to amyl, and other groups such as phenyl and benzyl. These compounds are to be tested elsewhere for hypnotic and anticonvulsant activity.
Date: 1957
Creator: Compton, Ross Davis