UNT Libraries - 62 Matching Results

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The Synthesis of N-(4-Nitrophenacyl)-4-Alkylpyridinium Halides and Reduction Products

Description: The synthesis of several N-(4-nitrophenacyl)-4-alkylpyridinium halides and their reduction products, 1-(4-aminophenyl)-2-[1-(4-alkylpiperidyl)]ethanols, was undertaken because of structural analogies between these and other physiologically active compounds, such as chloroamphenicol (I), 4,4'-diaminodiphenyl sulfone (II), and 2,2-bis(p-aminophenyl)-1,1,1-trichloroethane (III).
Date: 1950
Creator: Herd, Ray

Hydantoins as Anticonvulsants. III. 5-Alkoxy- and Aryloxymethyl-5-(2-Thienyl) Hydantoins

Description: It has been shown in the case of a compound synthesized in this laboratory that substitution of the thienyl group for one of the phenyl groups in diphenyl hydantoin produces a compound with less toxicity and somewhat greater activity. It was considered of interest to carry out an analogous substitution in the series of 5-phenyl-5-alkoxymethylhydantions.
Date: 1950
Creator: Sadler, Jack W.

The Hydrolysis of α-(Benzenesulfonyl)-Acetophenone

Description: In view of the unexpected behavior of α-(benzenesulfonyl)-acetophenone toward hydrolysis and because of the possible physiological importance of its derivatives it was deemed of interest to make a further study of the hydrolysis of this compound. It was decided to study both the acid and basic hydrolysis of this compound. The problem consisted of finding a satisfactory means of analyzing the hydrolysis products, and carrying out the hydrolysis under the different conditions.
Date: 1950
Creator: Looney, Jesse M.

A Comparison of the Achievements of Science and Non-Science Majors Enrolled in General Chemistry at North Texas State College

Description: It is the specific purpose of this investigation to determine the difference, if any, in the amount of practical, everyday chemistry learned by the science majors as opposed to the non-science majors enrolled in general chemistry at the North Texas State College during the school year 1950-1951.
Date: 1951
Creator: Brogdon, Billie R.

A Study of the Reduction Products of N-(4-Nitrophenacyl)-4-(1-Hexyl)pyridinium Bromide

Description: Because of the structural analogies between these compounds and several other physiologically active compounds, such as chloroamphenicol, 4,4'-diaminodiphenyl sulfone, and 2,2-bis-(p-aminophenyl)-1,1,1-trichloroethane, a more complete study of the reduction products and the sequence of catalytic reduction of N-(4-nitrophenacyl)-4-(1-hexyl)pyridinium bromide was made in this investigation.
Date: 1950
Creator: Arnwine, Bennie C.

Preparation of Pyridinium Derivatives of 2,3-Dichloro-5(8?)-Nitro-1,4-Naphthoquinone

Description: This paper describes the preparation of pyridine derivatives of 2,3-dichloro-5(8?)-nitro-1,4-naphthoquinone. A method for the nitration of 2,3-dichloro-1,4-naphthoquinone is also described. Certain 4-n-alkyl, 3,4-dialkyl, and 4-cycloalkyl pyridine derivatives are caused to undergo condensation reactions with the nitrated naphthoquinone, giving rise to a series of compounds of the preceding type (X). All of the compounds prepared will be tested for anti-tubercular activity by Parke-Davis and Company.
Date: 1955
Creator: Mahon, Frank

Barbituric Acids. VIII. 5-substituted-5-(1-pyrrolidyl)barbituric Acids

Description: The purpose of this investigation then was the preparation of a series of 5-substituted-5-(1-pyrrolidyl)barbituric acids in which R would consist of alkyl groups ranging in size from methyl to amyl, and other groups such as phenyl and benzyl. These compounds are to be tested elsewhere for hypnotic and anticonvulsant activity.
Date: 1957
Creator: Compton, Ross Davis

Synthesis of some 1-Substituted-2-Methylnaphthimidazole-4,9-Diones

Description: Imidazole derivatives of 1,4-naphthoquinones are found to have biological activity which interferes with the utilization of vitamin K or of the purines since they have groups common to these two classes of compounds. This thesis shows the preparation of some 1-substituted-naphthimidazole-4,9-diones for possible biological activity.
Date: August 1957
Creator: Peterson, Harold W.