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open access

Thymus Functionality Needs More Than a Few TECs

Description: Article is a review exploring the contributions of the many stromal cell types participating in the formation, expansion, and contraction of the thymus under normal and pathophysiological processes. Such information will better inform approaches for restoring thymus functionality, including thymus organoid technologies, beneficial when an individuals’ own tissue is congenitally, clinically, or accidentally rendered non-functional.
Date: June 10, 2022
Creator: Bhalla, Pratibha; Su, Dong-Ming & van Oers, Nicolai S. C.
Partner: UNT Health Science Center
open access

Traditional Chinese Medicine and Western Medicine Share Similar Philosophical Approaches to Fight COVID-19

Description: This article is a commentary exploring the disciplines of Western medicine and Traditional Chinese Medicine's philosophical methods to fight COVID-19 to understand their philosophical theories that could achieve the maximum benefits for treatment of COVID-19 and other diseases.
Date: August 1, 2021
Creator: Zhao, Fangfang; Yang, Zhenhong; Wang, Ningqun; Jin, Kunlin & Luo, Yumin
Partner: UNT Health Science Center
open access

Association of Home Food Availability with Prediabetes and Diabetes among Adults in the United States

Description: This article examined associations of home food availabilities with prediabetes and diabetes among 8929 adults (20–70 years) participating in 2007–2010 National Health and Nutrition Examination Surveys. The results show prediabetes participants had lower availability of healthy foods and higher availability of unhealthy foods, suggesting the need to improve healthy food availability at home for this population.
Date: April 25, 2020
Creator: McAtee, Jenniffer; Tao, Meng-Hua; King, Christian & Chai, Weiwen
Partner: UNT Health Science Center
open access

Peripheral Circulating Exosomal miRNAs Potentially Contribute to the Regulation of Molecular Signaling Networks in Aging

Description: This article aims to understand some of the causes of aging and the underlying mechanisms that may lead to interventions that could reverse certain aging processes and slow development of aging-related diseases. People are living longer than ever. Consequently, they have a greater chance for developing a functional impairment or aging-related disease, such as a neurodegenerative disease, later in life.
Date: March 11, 2020
Creator: Zhang, Hongxia & Jin, Kunlin
Partner: UNT Health Science Center
open access

17β-Estradiol Delivered in Eye Drops: Evidence of Impact on Protein Networks and Associated Biological Processes in the Rat Retina through Quantitative Proteomics

Description: Study analyzes target engagements through the identification of functional protein networks impacted after delivery of 17β-estradiol in eye drops to facilitate the development of broad-spectrum retina neuroprotectants that can be delivered through topical dosage forms.
Date: January 27, 2020
Creator: Prókai, László, 1958-; Zaman, Khadiza; Nguyen, Vien & Prokai-Tatrai, Katalin
Partner: UNT Health Science Center
open access

Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain

Description: Study examines intermittent hypoxic conditioning's (IHC) ability to alleviate harmful PTSD effects on a rat's heart, liver, and brain.
Date: January 5, 2020
Creator: Manukhina, Eugenia B.; Tseilikman, Vadim E.; Karpenko, Marina N.; Pestereva, Nina S.; Tseilikman, Olga B.; Komelkova, Maria V. et al.
Partner: UNT Health Science Center
open access

Trends in Magnesium Intake among Hispanic Adults, the National Health and Nutrition Examination Survey (NHANES) 1999-2014

Description: Paper describes the results of a study examining magnesium intake in Hispanic adults, using data from the NHANES from 1999-2014, stratified by gender, Hispanic origins, age, and poverty income ratio (PIR) level.
Date: November 22, 2019
Creator: Liu, Jialiang; Huang, Yuhan; Dai, Qi; Fulda, Kimberly G.; Chen, Shande & Tao, Meng-Hua
Partner: UNT Health Science Center
open access

A Novel Prodrug Approach for Central Nervous System-Selective Estrogen Therapy

Description: This article gives an overview of the discovery of small-molecule bioprecursor prodrugs carrying the para-quinol scaffold on the steroidal A-ring that are preferentially metabolized in the CNS to the corresponding estrogens. Selected examples are shown to illustrate that, independently of the route of administrations and duration of treatments, these agents produce high concentration of estrogens only in the CNS without peripheral hormonal liability. 10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)… more
Date: November 19, 2019
Creator: Prokai-Tatrai, Katalin & Prókai, László, 1958-
Partner: UNT Health Science Center
open access

Biodiversity of protists and nematodes in the wild nonhuman primate gut

Description: Article describes study which used an 18S rRNA gene fragment metabarcoding approach to assess the eukaryotic assemblage of 62 individuals representing 16 nonhuman primate NHP species to better understand the factors that influence the assembly and diversity of gut-associated eukaryotes.
Date: November 12, 2019
Creator: Mann, Allison E.; Mazel, Florent; Lemay, Matthew A.; Morien, Evan; Billy, Vincent; Kowalewski, Martin et al.
Partner: UNT Health Science Center
open access

“Youth Are More Aware and Intelligent than Imagined”: The Mountain Air Youth Photovoice Project

Description: This article looks at respiratory illness in Appalachian Kentucky because it reports some of the highest rates of respiratory illness in the United States. As part of the Mountain Air Project, local youth were invited to share their perspectives on possible contributing factors to respiratory illness, and the authors undertook an exploratory study to determine the utility of photovoice to elicit such perspectives with this population. This study demonstrates the value of incorporating youth per… more
Date: October 11, 2019
Creator: Cardarelli, Katheryn M.; Paul, Marcy; May, Beverly; Dunfee, Madeline; Browning, Steven & Schoenberg, Nancy
Partner: UNT Health Science Center
open access

Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach

Description: Using thyrotropin-releasing hormone (TRH) as a model, paper explores whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide.
Date: July 18, 2019
Creator: Prokai-Tatrai, Katalin; De La Cruz, Daniel L.; Nguyen, Vien; Ross, Benjamin P.; Toth, Istvan & Prókai, László, 1958-
Partner: UNT Health Science Center
open access

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

Description: The article is part of a series of Editorials published biannually that highlights a number of recently published articles that describe crucial findings.
Date: June 30, 2019
Creator: Mangoni, Arduino A; Vanden Eynde, Jean Jacques; Jampilek, Josef; Hadjipavlou-Litina, Dimitra; Liu, Hong; Reynisson, Jóhannes et al.
Partner: UNT Health Science Center
open access

Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

Description: This article is an overview the interplay between HIV-1 viral and cellular proteins for restrictions/competitions for proliferation of the virus in the infected cell, which could open a new avenue for the development of therapeutics against HIV-1 via targeting a specific step of the proteasome degradation pathway during the HIV-1 life cycle.
Date: June 19, 2019
Creator: Rojas, Vivian K. & Park, In-Woo
Partner: UNT Health Science Center
open access

Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors

Description: Study describes the use of a non-cytotoxic dose of histone deacetylase (HDAC) inhibitors to induce pulmonary carcinoid somatostatin receptor subtype 2 (SSTR2) expression to diagnose pulmonary carcinoids.
Date: June 3, 2019
Creator: Guenter, Rachael E.; Aweda, Tolulope; Matos, Danilea M. Carmona; Whitt, Jason; Chang, Alexander W.; Cheng, Eric Y. et al.
Partner: UNT Health Science Center
open access

Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract

Description: The article describes a study that tested and confirmed the hypothesis that TRPA1 expressed in the primary sensory afferents may modulate the function of second order NTS neurons. The expression of TRPA1 was detected in presynaptic locations, but not the somata of caudal NTS neurons that did not express TRPA1 mRNA or proteins. Moreover, caudal NTS neurons did not show somatodendritic responsiveness to TRPA1 agonists, while TRPA1 immunostaining was detected only in the afferent fibers.
Date: April 26, 2019
Creator: Feng, Lin; Uteshev, Victor V. & Premkumar, Louis S.
Partner: UNT Health Science Center
open access

The Enigmatic Protein Kinase C-eta

Description: The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death.
Date: February 13, 2019
Creator: Basu, Alakananda
Partner: UNT Health Science Center
open access

Treatment and Prevention of Recurrent Clostridium difficile Infection with Functionalized Bovine Antibody-Enriched Whey in a Hamster Primary Infection Model

Description: This article focuses on the development of an alternative drug for the treatment of Clostridium difficile infection (CDI). Oral administration of anti-CD-WPI is a functional therapy of CDI in infected hamsters for both primary treatment and prevention of recurrence. Thus, anti-CD-WPI could address the urgent unmet medical need for treating and preventing recurrent CDI in humans.
Date: February 6, 2019
Creator: Heidebrecht, Hans-Jürgen; Weiss, William J.; Pulse, Mark; Lange, Anton; Gisch, Karina; Kliem, Heike et al.
Partner: UNT Health Science Center
open access

Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress

Description: This article investigates if chronic inhibition of DLDH could also attenuate oxidative stress in type 2 diabetes. It is the authors' belief that DLDH inhibition could be a novel approach to fighting type 2 diabetes.
Date: February 2, 2019
Creator: Yang, Xiaojuan; Song, Jing & Yan, Liang-Jun
Partner: UNT Health Science Center
open access

Adherence to Exercise Programs in Older Adults: Informative Report

Description: This article focuses on filling information gaps regarding adherence to physical activity and exercise in the health care spectrum of older adults (OA) and an overview of the benefits of physical activity for OA. Exercise adherence in OA is a multifactorial problem encompassing many biopsychosocial factors. Factors affecting adherence in the OA include socioeconomic status, education level, living arrangements, health status, pacemakers, physical fitness, and depression. Improving adherence cou… more
Date: January 22, 2019
Creator: Rivera-Torres, Solymar; Fahey, Thomas D. & Rivera, Miguel A.
Partner: UNT Health Science Center
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