Dallas Voice (Dallas, Tex.), Vol. 28, No. 21, Ed. 1 Friday, October 7, 2011 Page: 40 of 68
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VIRAMUNE® (VIH-rah-mune) (nevirapine) Tablets
VIRAMUNE® (VIH-rah-mune) (nevirapine) Oral Suspension
VIRAMUNE® XR™ (VIH-rah-mune) (nevirapine)
Read this Medication Guide before you start taking VIRAMUNE and
each time you get a refill. There may be new information. This information
does not take the place of talking to your doctor about your medical
condition or treatment.
What is the most important information I should know about
VIRAMUNE can cause serious side effects. These include severe liver
and skin problems that can cause death. These problems can happen
at any time during treatment, but your risk is highest during the first
18 weeks of treatment.
1. Severe liver problems: Anyone who takes VIRAMUNE may get
severe liver problems. In some cases these liver problems can lead to
liver failure and the need for a liver transplant, or death.
People who have a higher 004' cell count when they begin VIRAMUNE
treatment have a higher risk of liver problems, especially:
• Women with CD4' counts higher than 250 cells/mm3. This group has
the highest risk.
• Men with CD4+ counts higher than 400 cells/mm3.
If you are a woman with CD4' counts higher than 250 cells/mm3 or a man
with CD4+ counts higher than 400 cells/mm3, you and your doctor will
decide whether starting VIRAMUNE is right for you.
In general, women have a higher risk of liver problems compared to men.
People who have abnormal liver test results before starting VIRAMUNE
treatment and people with hepatitis B or C also have a greater chance of
getting liver problems.
You may get a rash if you have liver problems.
Stop taking VIRAMUNE and call your doctor right away if you have
any of the following symptoms of liver problems:
• dark (tea colored} urine
• yellowing of your skin or whites of your eyes
• light-coiored bowel movements (stools)
• nausea (feeling sick to your stomach)
• feel unwell or like you have the flu
• pain or tenderness on your right side below your ribs
• loss of appetite
Your doctor should see you and do blood tests often to check your liver
function during the first 18 weeks of treatment with VIRAMUNE. You should
continue to have your liver checked regularly during your treatment with
VIRAMUNE. It is important for you to keep all of your doctor appointments.
2. Severe rash and skin reactions: Skin rash is the most common
side effect of VIRAMUNE. Most rashes happen in the first 6 weeks
of taking VIRAMUNE. Rashes and skin reactions may be severe,
life-threatening, and in some people, may lead to death. Stop
using VIRAMUNE and call your doctor right away if you get a rash
with any of the following symptoms:
• mouth sores
• red or inflamed eyes, like "pink eye" (conjunctivitis)
• liver problems (see symptoms of liver problems above)
• swelling of your face
• feel unwell or like you have the flu
• muscle or joint aches
If your doctor tells you to stop treatment with VIRAMUNE because you
have had any of the serious liver or skin problems described above,
you should never take VIRAMUNE again.
See the section "What are the possible side effects of VIRAMUNE?"
for more information.
What is VIRAMUNE?
VIRAMUNE is a prescription medicine used to treat Human
Immunodeficiency Virus (HIV), the virus that causes AIDS (Acquired
Immune Deficiency Syndrome).
VIRAMUNE is a type of anti-HlV medicine called a "non-nucleoside reverse
transcriptase inhibitor" (NNRTI). VIRAMUNE works by lowering the amount
of HIV in your blood ("viral load"). You must take VIRAMUNE with other
anti-HIV medicines. When you take VIRAMUNE with other anti-HIV
medicines, VIRAMUNE can lower your viral load and increase the number
of CD4r cells ("T cells"). CD4+ cells are a type of immune helper cell in the
blood. VIRAMUNE may not have these effects in every person.
VIRAMUNE comes in 3 different forms. This Medication Guide provides
information about all 3 forms of VIRAMUNE.
• VIRAMUNE tablets • VIRAMUNE oral suspension
• VIRAMUNE XR extended release tablets
VIRAMUNE XR extended-release tablets are not for use in children.
VIRAMUNE does not cure HIV or AIDS, and it is not known if it will help
you live longer with HIV. People taking VIRAMUNE may still get infections
common in people with HIV (opportunistic infections). It is very important
that you stay under the care of your doctor.
It is not known if VIRAMUNE lowers the chance of passing HtV to other
people. Effective treatment combined with safer sex practices, may
reduce the chance of passing HIV to others through sexual contacf. Always
practice safer sex by using a latex or polyurethane condom or other barrier
method to lower the chance of sexual contact with any body fluids such as
semen, vaginal secretions, or blood. Never re-use or share needles. Take
your HIV medicines as prescribed.
Who should not take VIRAMUNE?
Tell your doctor if you have or have had liver problems. Your doctor may tell
you not to take VIRAMUNE if you have certain liver problems.
VIRAMUNE is only for people diagnosed with HIV. If you have not been
diagnosed as HIV positive, then do not take VIRAMUNE.
What should I tell my doctor before taking VIRAMUNE?
Before you take VIRAMUNE, tell your doctor if you:
• have or have had hepatitis (inflammation of your liver) or problems with
your liver. See "What is the most important information I should
know about VIRAMUNE?" and "Who should not take VIRAMUNE?"
• receive dialysis
• have skin problems, such as a rash
• are pregnant or plan to become pregnant. It is not known if VIRAMUNE
will harm your unborn baby.
Pregnancy Registry: There is a pregnancy registry for women who
take antiviral medicines during pregnancy. The purpose of the registry
is to collect information about the health of you and your baby. Talk to
your doctor about how you can take part in this registry.
• are breast-feeding or plan to breast-feed. VIRAMUNE can pass
into your breast milk and may harm your baby. It is also recommended
that HIV-positive women should not breast-feed their babies. Do not
breast-feed during treatment with VIRAMUNE. Talk to your doctor about
the best way to feed your baby.
Tell your doctor and pharmacist about all the medicines you take,
including prescription and non-prescription medicines, vitamins and
herbal supplements. VIRAMUNE may affect the way other medicines work,
and other medicines may affect how VIRAMUNE works.
You should not take VIRAMUNE if you also take:
•St. John's Wort. St. John's Wort can lower the amount of VIRAMUNE in
•efavirenz (Sustiva®, Atripla®). Efavirenz may cause you to have an
increased chance of side effects.
• atazanavir (Reyataz®)
• lopinavir and ritonavir (Kaletra®)
•fosamprenavir calcium (Lexiva®)
• itraconazole (Sporanox®)
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Nash, Tammye. Dallas Voice (Dallas, Tex.), Vol. 28, No. 21, Ed. 1 Friday, October 7, 2011, newspaper, October 7, 2011; Dallas, Texas. (digital.library.unt.edu/ark:/67531/metapth239188/m1/40/: accessed September 24, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Special Collections.