Oral Spore-Based Probiotic Supplementation Was Associated With Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers Page: 117
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World Journal of
Gastrointestinal PathophysiologySubmit a Manuscript: http://www.f6publishing.com
DOI: 10.4291/wjgp.v8.i3.117World J Gastrointest Pathophysiol 2017 August 15; 8(3): 117-126
ISSN 2150-5330 (online)p ShuIly
Oral spore-based probiotic supplementation was associated
with reduced incidence of post-prandial dietary endotoxin,
triglycerides, and disease risk biomarkers
Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, Kimberly M CarbajalBrian K McFarlin, Andrea L Henning, Erin M Bowman, Melody
A Gary, Applied Physiology Laboratory, University of North
Texas, Denton, TX 76203, United States
Brian K McFarlin, Andrea L Henning, Kimberly M Carbajal,
Department of Biological Sciences, University of North Texas,
Denton, TX 76203, United States
Author contributions: McFarlin BK designed the study,
collected data, interrupted findings, and prepared manuscript;
Henning AL, Bowman EM, Gary MA and Carbajal KM collected
data, interrupted findings, and prepared manuscript.
Institutional review board statement: The study was reviewed
and approved by the UNT Institutional Review Board for Human
Subjects Research.
Informed consent statement: Subjects provided written and
oral consent to participate using an IRB-approved informed
consent form specific to the study in question.
Conflict-of-interest statement: The present study was funded
in part by a competitive research grant from Microbiome
Labs, LLC (Glenview, IL) to the University of North Texas.
The UNT team did not receivesdirect funding associated with
the completion of the present study. The funding agency was
not involved in the data collection, analysis, interpretation,
and manuscript preparation. Double blind procedures and
confidentially were used to conduct the present study in a sound
and unbiased manner. As such, the authors report no conflict of
interest associated with completing the present study.
Data sharing statement: None.
Open-Access: This article is an open-access article which was
selected by an in-house editor and fully peer-reviewed by external
reviewers. It is distributed in accordance with the Creative
Commons Attribution Non Commercial (CC BY-NC 4.0) license,
which permits others to distribute, remix, adapt, build upon this
work non-commercially, and license their derivative works on
different terms, provided the original work is properly cited and
the use is non-commercial. See: http://creativecommons.org/
f
JgAishiden9 VJGP I www.wjgnet.comlicenses/by-nc/4.0/
Manuscript source: Invited manuscript
Correspondence to: Brian K McFarlin, PhD, FACSM, FTOS,
Associate Professor, Applied Physiology Laboratory, University
of North Texas, 1921 West Chestnut Street, PEB Room 209,
Denton, TX 76203, United States. brian.mcfarlin@unt.edu
Telephone: +1-940-5653165
Fax: +1-940-5654904
Received: January 26, 2017
Peer-review started: February 8, 2017
First decision: April 17, 2017
Revised: July 4, 2017
Accepted: July 14, 2017
Article in press: July 17, 2017
Published online: August 15, 2017
Abstract
AIM
To determine if 30-d of oral spore-based probiotic supple-
mentation could reduce dietary endotoxemia.
METHODS
Apparently healthy men and women (n = 75) were
screened for post-prandial dietary endotoxemia. Subjects
whose serum endotoxin concentration increased by at
least 5-fold from pre-meal levels at 5-h post-prandial
were considered "responders" and were randomized to
receive either placebo (rice flour) or a commercial spore-
based probiotic supplement [Bacillus indicus (HU36),
Bacillus subtilis (HU58), Bacillus coagulans, and Bacillus
licheniformis, and Bacillus clausii] for 30-d. The dietary
endotoxemia test was repeated at the conclusion of
the supplementation period. Dietary endotoxin (LAL)
and triglycerides (enzymatic) were measured usingAugust 15, 2017 I Volume 8 I Issue 3 I
117
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McFarlin, Brian K.; Henning, Andrea L.; Bowman, Erin M.; Gary, Melody A. & Carbajal, Kimberly M. Oral Spore-Based Probiotic Supplementation Was Associated With Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers, article, August 15, 2017; Pleasanton, California. (https://digital.library.unt.edu/ark:/67531/metadc993395/m1/1/: accessed April 19, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Science.