Oral Spore-Based Probiotic Supplementation Was Associated With Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers

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This article contains a study to determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia.

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10 p.

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McFarlin, Brian K.; Henning, Andrea L.; Bowman, Erin M.; Gary, Melody A. & Carbajal, Kimberly M. August 15, 2017.

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This article contains a study to determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia.

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10 p.

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Abstract:
To determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia.
METHODS
Apparently healthy men and women (n = 75) were screened for post-prandial dietary endotoxemia. Subjects whose serum endotoxin concentration increased by at least 5-fold from pre-meal levels at 5-h post-prandial were considered “responders” and were randomized to receive either placebo (rice flour) or a commercial sporebased probiotic supplement [Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, and Bacillus licheniformis, and Bacillus clausii] for 30-d. The dietary endotoxemia test was repeated at the conclusion of the supplementation period. Dietary endotoxin (LAL) and triglycerides (enzymatic) were measured using Spore-based probiotics and dietary endotoxemia an automated chemistry analyzer. Serum disease risk biomarkers were measured using bead-based multiplex assays (Luminex and Milliplex) as secondary, exploratory measures.
RESULTS
Data were statistically analyzed using repeated measures ANOVA and a P < 0.05. We found that spore-based probiotic supplementation was associated with a 42% reduction in endotoxin (12.9 ± 3.5 vs 6.1 ± 2.6, P = 0.011) and 24% reduction in triglyceride (212 ± 28 vs 138 ± 12, P = 0.004) in the post-prandial period Placebo subjects presented with a 36% increase in endotoxin (10.3 ± 3.4 vs 15.4 ± 4.1, P = 0.011) and 5% decrease in triglycerides (191 ± 24 vs 186 ± 28, P = 0.004) over the same post-prandial period. We also found that sporebased probiotic supplementation was associated with significant post-prandial reductions in IL-12p70 (24.3 ± 2.2 vs 21.5 ± 1.7, P = 0.017) and IL-1β (1.9 ± 0.2 vs 1.6 ± 0.1, P = 0.020). Compared to placebo post supplementation, probiotic subject had less ghrelin (6.8 ± 0.4 vs 8.3 ± 1.1, P = 0.017) compared to placebo subjects.
CONCLUSION
The key findings of the present study is that oral sporebased probiotic supplementation reduced symptoms indicative of “leaky gut syndrome”.

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  • World Journal of Gastrointestinal Pathophysiology, 2017. Pleasanton, CA: Baishideng Publishing Group Inc.

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  • Publication Title: World Journal of Gastrointestinal Pathophysiology
  • Volume: 8
  • Issue: 3
  • Pages: 10
  • Page Start: 117
  • Page End: 126
  • Peer Reviewed: Yes

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  • January 26, 2017

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  • July 14, 2017

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  • August 15, 2017

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  • Sept. 17, 2017, 6:24 p.m.

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  • Oct. 31, 2023, 1:45 p.m.

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McFarlin, Brian K.; Henning, Andrea L.; Bowman, Erin M.; Gary, Melody A. & Carbajal, Kimberly M. Oral Spore-Based Probiotic Supplementation Was Associated With Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers, article, August 15, 2017; Pleasanton, California. (https://digital.library.unt.edu/ark:/67531/metadc993395/: accessed March 19, 2025), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Science.

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