The Distribution of Radioactivity in the Mouse Following Administration of Dibenzanthracene Labeled in the 9 and 10 Positions with Carbon Fourteen

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Dibenzanthracene, labeled in the 9 and 10 positions with carbon fourteen has been administered to mice intravenously and by stomach tube as an aqueous colloid, and intraperitoneally, subcutaneously, and by stomach tube in tricaprylin solution. The distribution of radioactivity in the mice at various time intervals after administration of the carcinogen has been determined. The radioactivity is rapidly eliminated, largely through the feces, and ordinarily very little is absorbed. The distribution and rate of elimination depends upon the mode of administration. There is an appreciable quantity of radioactivity in tumors produced several months after a single subcutaneous injection of dibenzanthracene. ... continued below

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Heidelberger, Charles & Jones, Hardin, B. January 30, 1948.

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Dibenzanthracene, labeled in the 9 and 10 positions with carbon fourteen has been administered to mice intravenously and by stomach tube as an aqueous colloid, and intraperitoneally, subcutaneously, and by stomach tube in tricaprylin solution. The distribution of radioactivity in the mice at various time intervals after administration of the carcinogen has been determined. The radioactivity is rapidly eliminated, largely through the feces, and ordinarily very little is absorbed. The distribution and rate of elimination depends upon the mode of administration. There is an appreciable quantity of radioactivity in tumors produced several months after a single subcutaneous injection of dibenzanthracene. There appear to be no detectable effects from the radiation of the labeled carcinogen.

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  • American Association for Cancer Research, Inc., Chicago, IL, May 1947

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  • Report No.: UCRL-43
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 971427
  • Archival Resource Key: ark:/67531/metadc934045

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Office of Scientific & Technical Information Technical Reports

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  • January 30, 1948

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  • Nov. 13, 2016, 7:26 p.m.

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  • Nov. 18, 2016, 2:35 p.m.

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Heidelberger, Charles & Jones, Hardin, B. The Distribution of Radioactivity in the Mouse Following Administration of Dibenzanthracene Labeled in the 9 and 10 Positions with Carbon Fourteen, article, January 30, 1948; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc934045/: accessed December 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.