Using a systems biological approach to develop novel therapeutics.

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With the human genome sequence available and with an exponentially growing number of completely sequenced genomes from various model organisms, the research paradigm is shifted towards the analysis of the function of interacting genes and gene-product. The reduced estimate of 30,000-40,000 genes in the human genome strongly indicates that the functional complexity expected for an organism such as human may originate in locations and processes beyond the identified genes. Functional genomics emerges as valuable research area for the identification of key-players in the complex processes within a living organism. It is complemented by Systems Biology [7,103,104], a new research area ... continued below

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6 p.

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Forst, C. (Christian) January 1, 2001.

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Description

With the human genome sequence available and with an exponentially growing number of completely sequenced genomes from various model organisms, the research paradigm is shifted towards the analysis of the function of interacting genes and gene-product. The reduced estimate of 30,000-40,000 genes in the human genome strongly indicates that the functional complexity expected for an organism such as human may originate in locations and processes beyond the identified genes. Functional genomics emerges as valuable research area for the identification of key-players in the complex processes within a living organism. It is complemented by Systems Biology [7,103,104], a new research area that combines data obtained from Functional Genomics analysis with biocomputation and simulation of cellular networks. Both Functional Genomics and Systems Biology outline the analysis, prediction and control of complex biological systems.

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6 p.

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  • Submitted to: Cambridge Healthtech Institute's Fifth Annual Functional Genomics Conference, Oct. 9-10, Cambridge, MA

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  • Report No.: LA-UR-01-6836
  • Grant Number: none
  • Office of Scientific & Technical Information Report Number: 975910
  • Archival Resource Key: ark:/67531/metadc929645

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 1, 2001

Added to The UNT Digital Library

  • Nov. 13, 2016, 7:26 p.m.

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  • Dec. 12, 2016, 1:45 p.m.

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Forst, C. (Christian). Using a systems biological approach to develop novel therapeutics., article, January 1, 2001; United States. (digital.library.unt.edu/ark:/67531/metadc929645/: accessed September 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.