Viral BLIP dynamics during HAART.

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Description

Intermittent episodes of low-level viremia (blips) are often observed in well-suppressed, HAART-treated patients. It has been reported that viral blips do not correlate with the emergence of new HAART-related mutations; however, increased frequency of blips correlates with slower decay of latently infected cells. Since blips are transient and unpredictable, detailed knowledge about them is difficult to obtain. We present an analysis of the dynamics of viral blips from viral load (VL) measurements on 123 patients for a period of 809k480d (21-1817d) and sampled every 31{+-}12d for a total of 26{+-}15 samples per patient.

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1 p.

Creation Information

Markowitz, M.; Louie, M. (Michael); Hurley, A. (Arlene); Ho, David D.; Perelson, Alan S., & Di Mascio, M. (Michele) January 1, 2001.

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Description

Intermittent episodes of low-level viremia (blips) are often observed in well-suppressed, HAART-treated patients. It has been reported that viral blips do not correlate with the emergence of new HAART-related mutations; however, increased frequency of blips correlates with slower decay of latently infected cells. Since blips are transient and unpredictable, detailed knowledge about them is difficult to obtain. We present an analysis of the dynamics of viral blips from viral load (VL) measurements on 123 patients for a period of 809k480d (21-1817d) and sampled every 31{+-}12d for a total of 26{+-}15 samples per patient.

Physical Description

1 p.

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  • Submitted to: 9th Conference on Retrovirus&Opportunisitic Infections, Seattle, WA Feb. 24-28, 2002

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  • Report No.: LA-UR-01-6667
  • Grant Number: none
  • Office of Scientific & Technical Information Report Number: 975898
  • Archival Resource Key: ark:/67531/metadc928205

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • January 1, 2001

Added to The UNT Digital Library

  • Nov. 13, 2016, 7:26 p.m.

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  • Dec. 12, 2016, 5:23 p.m.

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Markowitz, M.; Louie, M. (Michael); Hurley, A. (Arlene); Ho, David D.; Perelson, Alan S., & Di Mascio, M. (Michele). Viral BLIP dynamics during HAART., article, January 1, 2001; United States. (digital.library.unt.edu/ark:/67531/metadc928205/: accessed April 24, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.