DE-FG02-05ER64001 Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors

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The 4 specific aims of this project are: (1) Optimization of MST to increase tumor uptake; (2) Antigen heterogeneity; (3) Characterization and reduction of renal uptake; and (4) Validation in vivo of optimized MST targeted therapy. This proposal focussed upon optimizing multistep immune targeting strategies for the treatment of cancer. Two multi-step targeting constructs were explored during this funding period: (1) anti-Tag-72 and (2) anti-GD2.

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P.I. Steven M. Larson MD Co P.I. Nai-Kong Cheung MD, Ph.D. September 21, 2009.

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Description

The 4 specific aims of this project are: (1) Optimization of MST to increase tumor uptake; (2) Antigen heterogeneity; (3) Characterization and reduction of renal uptake; and (4) Validation in vivo of optimized MST targeted therapy. This proposal focussed upon optimizing multistep immune targeting strategies for the treatment of cancer. Two multi-step targeting constructs were explored during this funding period: (1) anti-Tag-72 and (2) anti-GD2.

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  • Report No.: DOE/ER/64001
  • Grant Number: FG02-05ER64001
  • Office of Scientific & Technical Information Report Number: 964281
  • Archival Resource Key: ark:/67531/metadc927561

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Office of Scientific & Technical Information Technical Reports

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  • September 21, 2009

Added to The UNT Digital Library

  • Nov. 13, 2016, 7:26 p.m.

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P.I. Steven M. Larson MD Co P.I. Nai-Kong Cheung MD, Ph.D. DE-FG02-05ER64001 Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors, report, September 21, 2009; United States. (digital.library.unt.edu/ark:/67531/metadc927561/: accessed October 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.