Effect of dephasing on DNA sequencing via transverse electronic transport

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We study theoretically the effects of dephasing on DNA sequencing in a nanopore via transverse electronic transport. To do this, we couple classical molecular dynamics simulations with transport calculations using scattering theory. Previous studies, which did not include dephasing, have shown that by measuring the transverse current of a particular base multiple times, one can get distributions of currents for each base that are distinguishable. We introduce a dephasing parameter into transport calculations to simulate the effects of the ions and other fluctuations. These effects lower the overall magnitude of the current, but have little effect on the current distributions ... continued below

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Zwolak, Michael; Krems, Matt; Pershin, Yuriy V & Di Ventra, Massimiliano January 1, 2009.

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We study theoretically the effects of dephasing on DNA sequencing in a nanopore via transverse electronic transport. To do this, we couple classical molecular dynamics simulations with transport calculations using scattering theory. Previous studies, which did not include dephasing, have shown that by measuring the transverse current of a particular base multiple times, one can get distributions of currents for each base that are distinguishable. We introduce a dephasing parameter into transport calculations to simulate the effects of the ions and other fluctuations. These effects lower the overall magnitude of the current, but have little effect on the current distributions themselves. The results of this work further implicate that distinguishing DNA bases via transverse electronic transport has potential as a sequencing tool.

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  • Journal Name: Biophysical Journal

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  • Report No.: LA-UR-09-01237
  • Report No.: LA-UR-09-1237
  • Grant Number: AC52-06NA25396
  • Office of Scientific & Technical Information Report Number: 956571
  • Archival Resource Key: ark:/67531/metadc926741

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  • January 1, 2009

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  • Nov. 13, 2016, 7:26 p.m.

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  • Dec. 9, 2016, 11:18 p.m.

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Zwolak, Michael; Krems, Matt; Pershin, Yuriy V & Di Ventra, Massimiliano. Effect of dephasing on DNA sequencing via transverse electronic transport, article, January 1, 2009; [New Mexico]. (digital.library.unt.edu/ark:/67531/metadc926741/: accessed November 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.