Proteins as paradigms of complex systems.

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The science of complexity has moved to center stage within the past few decades. Complex systems range from glasses to the immune system and the brain. Glasses are too simple to possess all aspects of complexity; brains are too complex to expose common concepts and laws of complexity. Proteins, however, are systems where many concepts and laws of complexity can be explored experimentally, theoretically, and computationally. Such studies have elucidated crucial aspects. The energy landscape has emerged as one central concept; it describes the free energy of a system as a function of temperature and the coordinates of all relevant ... continued below

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7 p.

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Fenimore, P. W. (Paul W.); Frauenfelder, Hans, & Young, R. D. (Robert D.) March 26, 2003.

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Description

The science of complexity has moved to center stage within the past few decades. Complex systems range from glasses to the immune system and the brain. Glasses are too simple to possess all aspects of complexity; brains are too complex to expose common concepts and laws of complexity. Proteins, however, are systems where many concepts and laws of complexity can be explored experimentally, theoretically, and computationally. Such studies have elucidated crucial aspects. The energy landscape has emerged as one central concept; it describes the free energy of a system as a function of temperature and the coordinates of all relevant atoms. A second concept is that of fluctuations. Without fluctuations, proteins would be dead and life impossible. A third concept is slaving. Proteins are not isolated systems; they are embedded in cells and membranes. Slaving arises when the fluctuations in the surroundings of a protein dominate many of the motions of the protein proper.

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7 p.

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  • Submitted to: International Society of Optical Engineers-Proceedings on "Fluctuations and Noise," June 1-4, 2003, Santa Fe, NM

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  • Report No.: LA-UR-03-2251
  • Grant Number: none
  • Office of Scientific & Technical Information Report Number: 976589
  • Archival Resource Key: ark:/67531/metadc926308

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  • March 26, 2003

Added to The UNT Digital Library

  • Nov. 13, 2016, 7:26 p.m.

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  • Dec. 12, 2016, 12:50 p.m.

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Fenimore, P. W. (Paul W.); Frauenfelder, Hans, & Young, R. D. (Robert D.). Proteins as paradigms of complex systems., article, March 26, 2003; United States. (digital.library.unt.edu/ark:/67531/metadc926308/: accessed June 25, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.