Development of Tc-99m Imaging Agents for Abeta Plaques

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Development of SPECT imaging agents based on Tc-99m targeting Aβ plaques is useful for diagnosis of Alzheimer’s disease (AD). A stilbene derivative, [11C]SB-13, showing promise in detecting senile plaques present in AD patients has been reported previously1,2. Based on the 4’-amino-stilbene core structure we have added substituted groups through which a chelating group, N2S2, was conjugated. We report herein a series of Tc-99m labeled stilbene derivative conjugated with a TcO[N2S2] core. The syntheses of stilbenes containing a N2S2 chelating ligand are achieved by a scheme shown. Lipophilic 99mTc stilbene complexes were successfully prepared and purified through HPLC. Preliminary results of ... continued below

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Zhi-Ping, Zhuang; Kung, Mei-Ping; Hou, Catherihne & Kung, Hank F. September 26, 2008.

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Development of SPECT imaging agents based on Tc-99m targeting Aβ plaques is useful for diagnosis of Alzheimer’s disease (AD). A stilbene derivative, [11C]SB-13, showing promise in detecting senile plaques present in AD patients has been reported previously1,2. Based on the 4’-amino-stilbene core structure we have added substituted groups through which a chelating group, N2S2, was conjugated. We report herein a series of Tc-99m labeled stilbene derivative conjugated with a TcO[N2S2] core. The syntheses of stilbenes containing a N2S2 chelating ligand are achieved by a scheme shown. Lipophilic 99mTc stilbene complexes were successfully prepared and purified through HPLC. Preliminary results of in vitro labeling of brain sections from transgenic mice showed very promising plaque labeling. These 99mTc stilbene derivatives are warranted for further evaluations as potential imaging agents targeting amyloid plaques.

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  • Report No.: ER63589 0009488
  • Grant Number: FG02-03ER63589
  • DOI: 10.2172/938779 | External Link
  • Office of Scientific & Technical Information Report Number: 938779
  • Archival Resource Key: ark:/67531/metadc902273

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  • September 26, 2008

Added to The UNT Digital Library

  • Sept. 27, 2016, 1:39 a.m.

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  • Nov. 23, 2016, 3:42 p.m.

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Zhi-Ping, Zhuang; Kung, Mei-Ping; Hou, Catherihne & Kung, Hank F. Development of Tc-99m Imaging Agents for Abeta Plaques, report, September 26, 2008; United States. (digital.library.unt.edu/ark:/67531/metadc902273/: accessed June 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.